iiinova — where your digital self keeps evolving

Chen-Yang Su, PhD @chenyangsu.bsky.social · 21/07/2025

Excited to give a talk on AI-Driven Integration of Multi-omics Data at Taiwan's Summer Workshop! So grateful to Dr. Yi-Hsiang Hsu @harvardmed.bsky.social for the invitation. Join us on July 25 @ 9 am Taipei Standard Time Website: bit.ly/46REINZ Schedule: bit.ly/40Zy9oW

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Chen-Yang Su, PhD @chenyangsu.bsky.social · 31/05/2025

Excited to share my 1st-year PhD rotation work in @thelancethaem.bsky.social 📰http://tinyurl.com/yaucnx73 We used ML to optimize blood donation with models validated in USA, South Africa, and Netherlands Big thanks to Wanjin and Alton for pushing it through during my return to genomics! 🧵

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Chen-Yang Su, PhD @chenyangsu.bsky.social · 26/05/2025

Deeply honored to attend a panel discussion and present at the Quebec Inflammatory Bowel Disease Research Conference. Heard amazing talks and had great discussions with Mark Daly, Judy Cho, Corinne Maurice, and Martin Pelletier. Thanks to John Rioux for the invitation!

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Chen-Yang Su, PhD @chenyangsu.bsky.social · 25/05/2025

Join @geneticepi.bsky.social for the Education Workshop "Navigating Biobank Data: Advanced Strategies for Genetic Epidemiology Research"! 🎫International Genetic Epidemiology Society (IGES) 🚨Education Workshop 📍 Cologne, Germany ⏲️ Aug 31, 2025 1:00 - 6:00 PM

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Chen-Yang Su, PhD @chenyangsu.bsky.social · 20/05/2025

Excited to be speaking and participating in a panel session at the Quebec Inflammatory Bowel Disease Research Conference (QIRC)! Time: Wednesday, May 21, 10:10 AM EST at CRCHUM in Montreal. Thanks to Karine Tremblay, Robert Battat, and John D. Rioux for the invitation!

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Chen-Yang Su, PhD @chenyangsu.bsky.social · 21/03/2025

I'm deeply grateful to the McGill Alan Edwards Centre for Research on Pain @mcgill.ca for inviting me as a speaker to give a workshop on Mendelian randomization! Many thanks to Pain Centre Student Association (PCSA) Executives Megan Tsao and Sam Zhou for organizing!

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Chen-Yang Su, PhD @chenyangsu.bsky.social · 24/01/2025

I am honored to serve for a two-year term on the IGES Young Investigators Committee from 2025-2027! Thank you to YIC Committee members for the nomination! All other YIC members: 👉 iges.memberclicks.net/young-invest...

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Chen-Yang Su, PhD @chenyangsu.bsky.social · 01/01/2025

Excited to give a talk on leveraging large-scale human genetics and multi-omics analysis for drug target discovery! So grateful to Dr. Pei-Lung Chen at National Taiwan University for the invitation. Join us on Jan 2 @ 5:15 pm Taipei Standard Time Website: bit.ly/41YznSG Past talks: bit.ly/3DDaGRK

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Chen-Yang Su, PhD @chenyangsu.bsky.social · 18/11/2024

⚠️ Ever wondered why losing weight is so hard? 😱 Scientists discover 'obesogenic memory'—fat cells holding on to epigenetic changes that promote weight regain.

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Chen-Yang Su, PhD @chenyangsu.bsky.social · 18/11/2024

To illustrate the value of our atlas, we highlight autoimmune diseases and pinpointed IL1RL1 implicated in inflammatory bowel diseases using multiple lines of evidence including replication MR in different ancestries, observational evidence, & bulk and single-cell RNA sequencing.

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Chen-Yang Su, PhD @chenyangsu.bsky.social · 18/11/2024

Naturally, we would want to know which of these proteins implicated in diseases are druggable. To answer this, we incorporated three drug databases. 💊The druggable genome 💊DrugBank 💊 opentargets.bsky.social.

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Chen-Yang Su, PhD @chenyangsu.bsky.social · 18/11/2024

We built an interactive web browser of all our results which are hosted on the Common Metabolic Diseases Knowledge Portal!

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Chen-Yang Su, PhD @chenyangsu.bsky.social · 18/11/2024

We performed extensive sensitivity analyses and colocalization analyses with PWCoCo and SharePro and identified 3,949, 56, and 325 putatively causal protein-phenotype pairs in European, African, and East Asian ancestries, respectively.

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Chen-Yang Su, PhD @chenyangsu.bsky.social · 18/11/2024

By including proteomics cohorts from non-European ancestries, we were able to test an additional 119 proteins that were unique in African ancestry and 17 in East Asian ancestry due to allele frequency differences.

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Chen-Yang Su, PhD @chenyangsu.bsky.social · 18/11/2024

As exposures, we used a total of 7 proteomics cohorts including a novel East Asian ancestry cohort from Kyoto university. As outcomes, we manually curated the largest GWAS for European and African ancestries, while outcomes from Biobank Japan were used for East Asian ancestry.

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Chen-Yang Su, PhD @chenyangsu.bsky.social · 18/11/2024

🚨NEW PREPRINT! Interested in Mendelian randomization and proteomics? 🧬 We created a comprehensive multi-ancestry proteome-phenome-wide atlas of protein-disease associations in European, African, and East Asian ancestries! Preprint: www.medrxiv.org/content/10.1... Website: broad.io/protein_mr_a...

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