Reposted by Changchao Li
⚡️A new piece of the puzzle in recurrent pregnancy loss: Hyperoside alleviates endometrial stromal cell senescence, restores decidualization, and reduces embryo loss partly by mitigating pathological R-loop accumulation.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
Hyperoside alleviates endometrial stromal cell senescence in unexplained recurrent spontaneous abortion via DHX9‐mediated R‐loop resolution
This study suggests that the food-derived flavonoid hyperoside may act as a natural DExH-box helicase 9 (DHX9) modulator, directly targeting Thr419 of DHX9 to help resolve pathological R-loop accumul...
