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cepru1100.bsky.social

@cepru1100.bsky.social
29 followers 26 following 26 posts
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cepru1100.bsky.social @cepru1100.bsky.social · 11/09/2026
🩸 Are we taking too much blood from our patients? Patient Blood Management also means preserving the patient’s own blood — an ethical, economic & environmental responsibility. Proud to see Prof. Antoine Guillon (CEPR) involved in this international work. www.degruyterbrill.com/document/doi...
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cepru1100.bsky.social @cepru1100.bsky.social · 23/06/2026
🫁 Can the route of administration improve cancer immunotherapy? Our latest study shows that local airway delivery boosts anti-tumor immunity in lung cancer and limits systemic side effects compared with intravenous treatment. Read more 👇 🔗 www.nature.com/articles/s41...
nature.com
Importance of the delivery route for the tolerability and efficacy of immunomodulatory agents for lung cancer - Scientific Reports
Scientific Reports - Importance of the delivery route for the tolerability and efficacy of immunomodulatory agents for lung cancer
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The EMBO Journal @embojournal.org · 03/12/2025
and here's the link to the article: www.embopress.org/doi/full/10....
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cepru1100.bsky.social @cepru1100.bsky.social · 20/05/2026
New publication from our lab in European Geriatric Medicine: using nationwide French data (>439k critically ill patients), we show that Intermediate Care Units (IMCUs) play a key role for elderly. A step-down pathway (ICU → IMCU) was associated with better 1-year survival! doi.org/10.1007/s419...
doi.org
Patterns of medical intermediate care unit use in critically ill very old patients in France - European Geriatric Medicine
Purpose The growing population of adults aged ≥ 80 represents major challenges for critical care. Intermediate care units (IMCUs) offer a level that could bridge the gap between ICU and standard ward, but information is lacking regarding IMCU use for older critically ill patients. This study aimed to characterize critical-care trajectories involving IMCU use among older critically ill patients at a national level. Methods A nationwide retrospective cohort study was conducted in France, including all patients hospitalized in medical critical care in 2018. Patients were categorized as young (18–64), old (65–79), and very old adults (≥ 80). Trajectories between critical care units and general wards were visualized using Sankey diagrams. Overall survival was represented with Kaplan–Meier curves according to trajectory patterns. Results Of 439,213 individuals admitted to medical critical care, 28.2% were aged ≥ 80. Among patients aged ≥ 80 admitted to an ICU, a step-up strategy (IMCU before ICU) was used in 12% of patients, and a step-down strategy (ICU followed by IMCU) in 23%. The step-up strategy was associated with high mortality in critical care (46.6%, compared to 33.9% for patients admitted directly to an ICU). Step-down patients had an extended critical care length of stay; however, those discharged from critical care via step-down strategy showed a lower cumulative mortality at one year (RR 0.86). Conclusion IMCUs play a central role in the management of very old critically ill patients. The potential benefit of IMCU care for older adults transitioning out of the ICU should be evaluated in prospective clinical trials.
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cepru1100.bsky.social @cepru1100.bsky.social · 29/04/2026
😊 Pleased to share a recent study from our lab exploring a key question in critical care: can AI support ICU admission decisions? 🔍The authors highlight the complexity, subjectivity, ethical dimensions and the limits of AI in these decisions ! 👉 Read the article: link.springer.com/article/10.1...
link.springer.com
Decision-making for ICU admission: is there a place for AI? Exploring and understanding meaning, experiences, and perspectives - BMC Medical Ethics
BMC Medical Ethics - Intensive care unit (ICU) admission (or refusal) decisions are intricate, relying on the assessment of patient benefit by the intensivist, sole decision-maker, without clear...
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CNRS Biologie @cnrsbiologie.bsky.social · 23/04/2026
🔎 Comprendre le concept de « niche du macrophage » et étudier les fonctions de ces cellules dans différents organes. Une ambition portée par Marc Bajénoff, médaille d’argent du @cnrs.fr 👉 Son portrait : buff.ly/GkwGQB3
buff.ly
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cepru1100.bsky.social @cepru1100.bsky.social · 23/04/2026
😀 Let’s talk about biofilm ! with Pr. Christine Imbert (UMR7267 –Ecologie, biologie des interactions, Poitiers) during a seminar at the April, Monday 27 –at 11 am. Feel free to join us ! (Bat47C, 1st Floor)
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cepru1100.bsky.social @cepru1100.bsky.social · 23/03/2026
🤖 AI & Biomedical Research Workshop 🧬 31st March 2026 Join us for a workshop led by Hughes Berry (Inserm AI & Digital Unit). 🔬 Opportunities, use cases & challenges 🏛️ Inserm AI initiatives 💬 Open discussion with researchers A great opportunity to explore AI potency and issues.
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cepru1100.bsky.social @cepru1100.bsky.social · 23/03/2026
😀 Very honoured to welcome Rebecca Palmer (Malaghan Institute, Wellington, New Zealand) for a seminar at the CEPR on Tuesday 30th of March at 11 am. Feel free to join us ! (Bat47C, 1st Floor)
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Journal of Experimental Medicine @jem.org · 23/03/2026
Noncanonical T cell responses are associated with protection from #tuberculosis in mice and humans. From Proulx, Wiggins, Lauffenburger, Sassetti et al. rupress.org/jem/article/... 📘 Updates on the Immune Responses to #TB and #HIV: rupress.org/jem/collecti... #KSTB26 #KSHIVVax26
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Cell Press @cellpress.bsky.social · 23/03/2026
Chemisorptive carbon capture sees the light dlvr.it/TRfjDY Phillip J. Milner & Bayu I.Z. Ahmad @cornellupress.bsky.social @cp-trendschem.bsky.social #ACSSpring2026
Chemisorptive carbon capture sees the light
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cepru1100.bsky.social @cepru1100.bsky.social · 20/12/2025
🎓Mike Pasteur (Team 3) brilliantly defended his thesis—supervised by Virginie Hervé and Sandrine Le Guellec—entitled "Biomimetic model of human nasal cavities for inhaled antibody development. 👏 Congratulations, Mike, on this monumental work, which was enthusiastically praised by your jury!
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cepru1100.bsky.social @cepru1100.bsky.social · 19/12/2025
Congratulations to Florian Veillard on successfully defending and obtaining his HDR! A brilliant presentation for a brilliant career that continues at the CEPR! @University of Tours @cepru1100.bsky.social @inserm.fr
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cepru1100.bsky.social @cepru1100.bsky.social · 19/12/2025
Sandra Khau (Team 1), supervised by Mustapha Si-Tahar and Benoit Briard, has brilliantly defended her thesis entitled "Study of inflammasome regulation during bacterial and fungal superinfection in cystic fibrosis." Congratulations, Sandra!
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cepru1100.bsky.social @cepru1100.bsky.social · 02/12/2025
👏 Congratulations to our PhD student Katia Montero-Diaz for her excellent presentation at the #SFMNano congress in Lyon! 👍 A great showcase of the progress taking place in our lab (Pharmacology of Inhaled Pharmaceuticals team) and within the RNAVAC consortium
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cepru1100.bsky.social @cepru1100.bsky.social · 02/12/2025
👍 Nice work from Sandra Khau and colleagues from CEPR INSERM Lab (Team “ Pathophysiology of lung infections") in @embojournal.org. They propose a didactic review summarizing the cytosolic receptors and the signaling pathways involved in antifungal innate immunity.
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cepru1100.bsky.social @cepru1100.bsky.social · 20/10/2025
Le CEPR était bien représenté à #Biotechnocentre ! Bravo à Baptiste Rigoux et Katia Montero-Diaz pour leurs posters ainsi qu’à Nathalie Heuzé-Vourc’h et Christophe Paget pour leurs présentations. Mention particulière à Alexis David, qui repart avec le prix de la meilleure communication orale !
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cepru1100.bsky.social @cepru1100.bsky.social · 02/10/2025
Congratulations to our doctoral students, Enzo Vidy, Katia Montero-Diaz, and postdoctoral fellow Bhupinder Kaur, for their excellent presentations at the PEPR BBTI conference in Montpellier! A wonderful showcase of the advances taking place at the CEPR #France2030 #PEPR
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cepru1100.bsky.social @cepru1100.bsky.social · 09/09/2025
😊 Very proud to show our new article published in J Med Chem! 🎓 We showed the interest of a new linker technologies allowing the production of high-performance immunoconjugates with improved plasma stability and internalization within cancer cells compared to T-DXd. pubs.acs.org/doi/10.1021/...
pubs.acs.org
Development of Optimized Exatecan-Based Immunoconjugates with Potent Antitumor Efficacy in HER2-Positive Breast Cancer
The prognosis of human epidermal growth factor receptor 2 (HER2)-positive breast cancer has significantly improved with the advent of anti-HER2 therapies, especially antibody-drug conjugates (ADCs). I...
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cepru1100.bsky.social @cepru1100.bsky.social · 31/07/2025
😊 Excited to share our latest publication on the impact of biological barriers on inhaled antibodies! 👏 TThe result of a highly productive and enjoyable partnership with CSL Behring. Special thank you to @Anna Schnell and ther team for their great contributions! doi.org/10.1016/j.ejpb.2025.114817
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cepru1100.bsky.social @cepru1100.bsky.social · 11/07/2025
Great ANR-2025 results our lab!! Congratulations to Christophe Paget and Nathalie Heuzé-Vourc'h for their participation in PRC programs! Congratulations to Noémie Alphonse and Benoît Briard for obtaining their Young Researcher grants. Exciting discoveries and a new dynamic for our teams!
cepru1100.bsky.social
cepru1100.bsky.social
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CNRS @cnrs.fr · 01/07/2025
#CNRSdurable Alors que les conséquences environnementales et sanitaires de l’usage du plastique sont mieux étudiées, un certain nombre de laboratoires de recherche s’efforcent de mesurer l’empreinte plastique qu’ils génèrent, pour mieux la réduire.
cnrs.fr
Moins de plastique en recherche : les laboratoires ouvrent la voie
Moins de plastique en recherche : les laboratoires ouvrent la voie
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cepru1100.bsky.social @cepru1100.bsky.social · 01/07/2025
👏 Very proud of the phD students of the CEPR INSERM Lab!! Oral communications and posters for the PhD Day of the Région Centre-Val de Loire. 😀 Well done guys! You fly the our laboratory's flag high @insermgrandouest.bsky.social @Université de Tours
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cepru1100.bsky.social @cepru1100.bsky.social · 12/06/2025
Very honoured to welcome Dr. Yves Delneste (CRCI2NA, Nantes) for a seminar at the CEPR Feel free to join us!
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cepru1100.bsky.social @cepru1100.bsky.social · 28/05/2025
👏 N'hésitez pas à aller écouter la très belle intervention de Mike Pasteur (doctorant, Equipe 3 du CEPR INSERM Lab) lors du webinaire du GRISOF 💡 "La science en train de se faire": Aérosolthérapie par voie nasale www.youtube.com/watch?v=Qp6M...
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CNRS @cnrs.fr · 22/05/2025
🎬 Momoko Seto réalisatrice au CNRS, présente son premier long métrage « Planètes » à la Semaine de la critique du festival de #Cannes2025 Dans un dialogue constant entre science et fiction, elle filme le vivant : champignons, blobs, cristaux, micro-organismes…🍄
lejournal.cnrs.fr
Momoko Seto, exploratrice du vivant
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Inserm @inserm.fr · 22/05/2025
L'Inserm est trop fier de recevoir aujourd'hui le Prix #Festicomsante du #PodcastSanté Francophone 2025 X MedShake Studio pour son podcast "Les Volontaires", dans la catégorie "Recherche médicale et Industrie" 🤩🎉
Image décorative
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cepru1100.bsky.social @cepru1100.bsky.social · 23/05/2025
📻 L’équipe 3 du CEPR INSERM Lab is ON AIR sur la Méridienne de Radio Campus Tours 99.5 FM pour parler de nos différents modèles d'étude in vitro pour le développement des nouvelles thérapies inhalées 👏 Un grand merci à Melissa Wyckhuyse, Pierre DaSilva (PhD) et Jean-Michel Escoffre
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cepru1100.bsky.social @cepru1100.bsky.social · 20/05/2025
Congratulations to Alexis DAVID for taking part in the third edition of ‘My PhD in Comics’ from the University of Tours 🙏He collaborated with Pellichi, to create a comic strip illustrating his thesis. 🧠 Great opportunity for the PhD students, to learn about scientific outreach and communication
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cepru1100.bsky.social @cepru1100.bsky.social · 09/05/2025
👏 Well done Thomas Baranek (CEPR, Team 4) for securing a grant from Ligue contre le Cancer to support his work on the antitumoral activities of iNKT cell subsets.
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cepru1100.bsky.social @cepru1100.bsky.social · 09/05/2025
👏 Congratulations to Noemie Alphonse (Team 3) for obtaining both EMBO and MSCA Postdoctoral Fellowships 💡 Her project will focus on deciphering the immumodulatory properties of mucosal immune complexes
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cepru1100.bsky.social @cepru1100.bsky.social · 09/05/2025
😊 FAIR Project (coordinated by JC. Sirard, Pasteur Institute) reaches key milestone with launch of Phase I Clinical Trial for FLAMOD, an innovative therapy targeting respiratory infections. Great collaboration between CEPR's Team 1 (M. Si-Tahar/Antoine Guillon) and Team 3 (Nathalie Heuzé-Vourc'h) !
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cepru1100.bsky.social @cepru1100.bsky.social · 09/05/2025
😊 We are very proud and pleased to have received funding from the ANRS-MIE PEPR 2024. 👨‍🔬 This project project is coordinated by M.Epardaud (INRAe) and T.Sécher (CEPR-Inserm). 🔬- InHEALation aims to develop an innovative prophylactic and therapeutic inhaled platform against respiratory viruses.
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