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Christopher Snow

@cdsnow.bsky.social

642 followers 359 following 8 posts

Professor at Colorado State University. Previously MIT Chemistry (Tidor), Stanford Biophysics (Pande), Caltech Chemistry and Chemical Engineering (Arnold). Interests: Protein Engineering, Computational Protein Design, ML, Biomolecular Crystals

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Christopher Snow @cdsnow.bsky.social · 10/03/2026

We built DNA scaffold crystals that can be reprogrammed to host different guest proteins for X-ray structure determination — no new crystallization screen required. This animation shows a guest protein (glowing) seeking its designed binding site inside the crystal lattice. shorturl.at/DANdc

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Christopher Snow @cdsnow.bsky.social · 25/11/2024

AlphaFold3 Cautionary Tale: We deposited multiple PDB entries for “CJ,” a binding protein that domain swaps when crystallizing. Local AF3 in the presence of decane gives the domain swapped form with high confidence extended N-terminus (4/5 models). Yikes! Perhaps template-driven false confidence...

Protein cartoon, mostly depicted in blue for very high confidence (pLDDT) despite extended N-terminus as it exists in a domain swap...

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