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Cameron Dale MacQuarrie

@cdmacquarrie.bsky.social
441 followers 619 following 56 posts

Scientist at Arcadia Science Berkeley, CA, USA Cell Biology He/Him

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Cameron Dale MacQuarrie @cdmacquarrie.bsky.social · 19/02/2026
New pub from @ArcadiaScience 🧵 We found that C. smithii — a freshwater green alga — undergoes wild morphological transformations when grown on Marine Broth. Huge cells with mysterious wisp-like appendages. Here's what we saw. thestacks.org/publications... [1/9]
thestacks.org
Morphological transformation of Chlamydomonas smithii grown in Marine Broth medium
Marine Broth induces extreme morphological transformation in C. smithii: Cells shift from typical ellipsoid shape to amorphous forms with thin wisp-like appendages containing mitochondria, revealing u...
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Cameron Dale MacQuarrie @cdmacquarrie.bsky.social · 06/12/2025
Excited to share some new work from @arcadiascience.com at #CellBio2025! We’re using Chlamydomonas reinhardtii as a rapid in vivo platform to model ADA1 deficiency and test computationally designed therapeutic ADA1 variants. Poster PDF: bit.ly/chlamy-ADA
bit.ly
Chlamydomonas Cellular Phenotypes Enable in vivo Validation of Computationally Designed Therapeutic ADA1 Variants
Poster presented at CellBio 2025 in Philadelphia, PA. December 2025Abstract:Adenosine deaminase (ADA) deficiency causes severe combined immunodeficiency, and current treatments include enzyme replacem...
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Cameron Dale MacQuarrie @cdmacquarrie.bsky.social · 22/05/2025
Discovered some unexpected growth phenotypes in Chlamydomonas flagellar mutants! The cpc1-1 strain (with central pair complex defects) shows surprising metabolic traits that might be independent of its flagellar defects. 🧵 research.arcadiascience.com/pub/observat... [1/9]
research.arcadiascience.com
Chlamydomonas cpc1-1 mutant exhibits unexpected growth phenotypes
Comparative analysis of <i>Chlamydomonas </i>strains revealed that a <i>cpc1-1</i> mutant has three unexpected growth phenotypes across different media types, suggesting possible genetic background co...
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Reposted by Cameron Dale MacQuarrie
Arcadia Science @arcadiascience.com · 12/02/2025
Happy Darwin Day! Today, we’re thinking about how to use evolution to accelerate biomedical research. We think the answer is to expand the repertoire of organismal models. Search for the best ones using our new portal, Zoogle: zoogle.arcadiascience.com 🧵
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Cameron Dale MacQuarrie @cdmacquarrie.bsky.social · 17/12/2024
Today at #CellBio24, I'll discuss our new pub at the "Quantitative Biology in Emerging Model Systems" subgroup session at 5:15 pm in Ballroom 20A. Come check it out!
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Cameron Dale MacQuarrie @cdmacquarrie.bsky.social · 17/12/2024
Today at #CellBio24, Dave Mets will be at poster B599 talking about mapping genotypes to phenotypes! poster: zenodo.org/records/1449...
zenodo.org
G-P Atlas: a neural network for hollistically mapping genotypes to phenotypes
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Cameron Dale MacQuarrie @cdmacquarrie.bsky.social · 16/12/2024
Our new pub dropped this weekend! For those at #CellBio24, I'll be at poster B73 starting at 11:15 am discussing this work! I'll also be giving a talk on Tuesday at 5:15 pm in Ballroom 20A in the Quantitative Biology in Emerging Model Systems session poster here: zenodo.org/records/14481493
zenodo.org
Rescuing Chlamydomonas Motility in Mutants Modeling Spermatogenic Failure
Poster file created for CellBio2024 (ASCB / EMBO) based on the pub Essock-Burns T, Lane R, MacQuarrie CD, Mets DG. (2024). Rescuing Chlamydomonas motility in mutants modeling spermatogenic failure. ht...
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Cameron Dale MacQuarrie @cdmacquarrie.bsky.social · 16/12/2024
🧵 New from @arcadiascience.bsky.social: We used Chlamydomonas mutants to model specific types of spermatogenic failure and found drugs can rescue swimming behavior in mutation-specific ways. Full pub: research.arcadiascience.com/pub/result-chlamy-spgf [1/8]
research.arcadiascience.com
Rescuing Chlamydomonas motility in mutants modeling spermatogenic failure
We used Chlamydomonas reinhardtii motility mutants with disrupted genes homologous to human SPEF2 or DNALI1 to model spermatogenic failure disorders SPGF43 and SPGF83, respectively. We recovered aspec...
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Cameron Dale MacQuarrie @cdmacquarrie.bsky.social · 15/12/2024
Tomorrow at #CellBio24, I'll be at poster (B73) talking about some fun new work we just released using Chlamydomonas to model spermatogenic failure. Check out the poster here: zenodo.org/records/14481493 Join the fun and post your comments & questions on the pub! bit.ly/chlamy-spgf
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Cameron Dale MacQuarrie @cdmacquarrie.bsky.social · 15/12/2024
Happening soon at #CellBio24 @ascbiology.bsky.social Ryan York's poster (B574) on a data-driven approach to selecting your model organism @arcadiascience.bsky.social Poster here: zenodo.org/records/14479386 Join the fun & post your comments & questions on the pub! bit.ly/evolutionary...
bit.ly
Leveraging evolution to identify novel organismal models of human biology
Researching just a handful of organisms limits biological discovery. We developed an approach pairing organisms with biological questions to expand research biodiversity.
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Reposted by Cameron Dale MacQuarrie
Prachee Avasthi @pracheeac.bsky.social · 15/12/2024
Ryan’s poster: zenodo.org/doi/10.5281/... The concept: research.arcadiascience.com/pub/idea-sel... The approach and analyses: research.arcadiascience.com/pub/result-e... The validation: research.arcadiascience.com/pub/result-c...
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Reposted by Cameron Dale MacQuarrie
Prachee Avasthi @pracheeac.bsky.social · 15/12/2024
If you’re at #CellBio2024 drop by Ryan’s poster today (Board B574) to hear the latest from @arcadiascience.bsky.social about how you can choose the right model system for your research or find areas best studied in the species you have expertise/infrastructure Poster and publications below
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Reposted by Cameron Dale MacQuarrie
Joseph W. Brown @josephwb.bsky.social · 19/10/2024
Annual reminder that PhyloPic is your free go-to source for organismal silhouettes for #Jack-o'-lantern designs phylopic.org @tmkeesey.bsky.social 🧪
phylopic.org
PhyloPic
PhyloPic is an open database of free silhouette images of animals, plants, and other life forms, available for reuse under Creative Commons licenses. Download silhouettes for use in educational materi...
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Cameron Dale MacQuarrie @cdmacquarrie.bsky.social · 13/12/2023
Two weeks ago we @arcadiascience.bsky.social posted our final, major update to our Chlamydomonas sp. phenotypic variation pub! research.arcadiascience.com/pub/result-c...! A lot of new findings in the 🧵!!! 1/9
research.arcadiascience.com
Phenotypic differences between interfertile Chlamydomonas species · Genetics: Decoding evolutionary...
We’re crossing C. reinhardtii and C. smithii algae for high-throughput genotype-phenotype mapping. In preparation, we’re comparing the parents to uncover unique species-specific phenotypes.
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Cameron Dale MacQuarrie @cdmacquarrie.bsky.social · 01/12/2023
🎉 Excited to share our latest work at #CellBio23! I'll be presenting a poster on our pub “Phenotypic differences between interfertile Chlamydomonas species” and our continued work in the Protists and Parasites Cell Biology poster session (Board #723) @arcadiascience.bsky.social
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Cameron Dale MacQuarrie @cdmacquarrie.bsky.social · 11/11/2023
DALL-E's take on a colored pencil sketch of Chlamydomonas
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Cameron Dale MacQuarrie @cdmacquarrie.bsky.social · 15/09/2023
🚨 @arcadiascience.bsky.social is hiring an Image Analysis scientist!!! 🔬 jobs.lever.co/arcadiascien...
jobs.lever.co
Arcadia Science - Scientist, Image Analysis
A Bit About Us: We are Arcadia Science. Arcadia is a science company founded and led by scientists. Our mission is to transform evolutionary innovations into real-world solutions by openly developing ...
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Cameron Dale MacQuarrie @cdmacquarrie.bsky.social · 06/09/2023
Are you a Chlamydomonas reinhardtii or Chlamydomonas smithii? Find out here!!! www.buzzfeed.com/cameronmacqu... #SpiritAlgae And check out the latest version of our @arcadiascience.bsky.social pub comparing the 2 species! research.arcadiascience.com/pub/result-c... #ArcadiaGenetics
buzzfeed.com
Are You Chlamydomonas Reinhardtii Or Chlamydomonas Smithii?
Which microalgal species are you? Read the pub here: https://research.arcadiascience.com/pub/result-chlamydomonas-phenotypes/
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Reposted by Cameron Dale MacQuarrie
Arcadia Science @arcadiascience.com · 01/09/2023
🗣️ Calling all microscopy enthusiasts! We're looking for publicly available, open-source video data featuring bright-field, DIC, or phase-contrast images. These data will complement our own in a new study on focus-filtering techniques. Please comment with a link to a public repository!
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Cameron Dale MacQuarrie @cdmacquarrie.bsky.social · 01/09/2023
New pub update from @arcadiascience.bsky.social! ! We've just released an update to our research on the 2D cell morphology of C. reinhardtii and C. smithii, two interfertile algal species. research.arcadiascience.com/pub/result-c...
Diversity and mean of 2D morphology measurements of the 2 species
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