Computational single-cell investigation of extrachromosomal DNA and replication-timing alterations shaping metastatic cancer Primary supervisor: Simone Zaccaria, UCL Secondary supervisors: Benjamin Werner, Queen Mary University of London; Mariam Jamal-Hanjani, UCL Project High-level copy-number amplification of oncogenes is a common mechanism of cancer activation and a major source of intratumoural heterogeneity, poor outcomes, and treatment resistance .

DNA-sequencing data from primary tumours and paired metastases from participants in the TRACERx lung study and PEACE autopsy programme are used to analyse the metastatic diversity of advanced non-smal...

We are the Computational Cancer Genomics (CCG) Lab at the UCL Cancer Institute, a group of passionate scientists and clinicians who work on developing computational methods to unravel cancer's mysteri...