The ruthenium-catalyzed meta-C–H alkylation is an increasingly powerful strategy in the arena of remote C–H activation. Currently, the synthesis utility of this strategy is compromised owing to its re...

Cobaltaelectro-catalyzed C─H activation enables simultaneous construction of indoles with up to two distinct C─N chiral axes. High stereoselectivity derives from newly developed chiral κ2-N,O-oxazoli...

A multitask graph neural network is developed with mechanism-informed reaction graphs for site-selectivity prediction of ruthenium-catalysed C‒H functionalization of arenes. The extrapolative predicti...

Nature Catalysis, Published online: 07 March 2025; doi:10.1038/s41929-025-01306-9Controlling the selectivity of electrocatalysed C–H activation with earth-abundant base metals can increase its synthetic impact. Now chemodivergence of an electrocatalysed…

The high fraction of sp3-hybridized carbon atoms (Fsp3) in cyclobutanes makes them promising bioisosteres for arenes. Now by combining bicyclo[1.1.0]butane C–C activation with remote meta-C–H function...