iiinova — where your digital self keeps evolving

Byron Purse @byronpurse.bsky.social · 07/01/2026

Our team did a fantastic job at this study and I'm thrilled to share these new results! Thanks, everyone.

Byron Purse @byronpurse.bsky.social · 12/12/2025

Our latest paper is now out in @rscchembio.rsc.org! DEAtC exists as a dark, T-like tautomer in single strands, but when it base-pairs with G in dsDNA it shifts to a bright, C-like tautomer, explaining the mechanism behind its selective fluorescence turn-on signal. 😃 pubs.rsc.org/en/content/a...

pubs.rsc.org

Sequence-specific fluorescence turn-on arises from base pairing-templated tautomerism in the tricyclic cytidine analogue DEAtC

Fluorescent probes for measuring the structure, dynamics, cellular localization, and biochemistry of DNA and RNA are useful for determining the regulatory mechanisms of gene expression. Intrinsically ...

020

Byron Purse @byronpurse.bsky.social · 03/07/2025

I'm very excited to share that my research group has been awarded 3 new major grants this summer, an NIH MIRA, an NSF single-investigator, and another NSF with the Ralph Kleiner Lab. These focus on fluorescent nucleosides and RNA chemical biology. New group photo too! Yay team! 🥳

010

Byron Purse @byronpurse.bsky.social · 25/06/2025

Call for Abstracts: An oral symposium on Synthetically Modified Nucleosides and Nucleic Acids on October 26, 2025 at the @calacs.bsky.social‬ Western Regional Meeting in San Jose! Apply, share widely, and DM or email me with questions. wrm2025.org/index.php/pr...

000

Byron Purse @byronpurse.bsky.social · 04/02/2025

Check out our new article in @chemsci.bsky.social, "Single-molecule detection of oligonucleotides using the fluorescent nucleobase analogue ABN", just out today! Congrats to the student authors and a big thanks to my collaborators, Anita Jones and Youngkwang Lee. pubs.rsc.org/en/Content/A...

pubs.rsc.org

Single-molecule detection of oligonucleotides using the fluorescent nucleobase analogue ABN

Fluorescent nucleobase analogues (FBAs) have emerged as powerful tools for understanding nucleic acid systems at the molecular level. However, their application at the single-molecule level has been l...

010

Byron Purse @byronpurse.bsky.social · 03/02/2025

I’m excited to share that the San Diego State University College of Sciences is hiring a Tenure Track/Tenured Assistant or Associate Professor in Translational Science, broadly defined, to begin Fall 2025. For full details and to apply, see <https://apply.interfolio.com/162439>.

021

Byron Purse @byronpurse.bsky.social · 06/12/2024

I'm exited and honored to be an invited speaker at #CABSCon9 at CSU Fullerton today! Thanks to Prof. Stevan Pecic for the invitation.

010

Byron Purse @byronpurse.bsky.social · 05/12/2024

I’m super excited to share something totally different from my research—my band’s first EP! Big 🙏 to my bandmates Pat Shanley and Ryan Woempner. Check it out! It's on the other major streaming services too. open.spotify.com/album/1gZBUA...

open.spotify.com

Moonshine

Pat Shanley Band · EP · 2024 · 5 songs

030

Byron Purse @byronpurse.bsky.social · 29/11/2024

This Thanksgiving, the Purse Lab would like to thank our friends at Pfizer La Jolla for selecting us to receive research support as a part of their Green Chemistry Awards program. Special thanks to Dr. Paul Richardson! This helps to support new student initiatives in nucleosides chemistry.

030

Reposted by Byron Purse

Thorn-Seshold Lab @thornsesholdlab.bsky.social · 17/11/2024

📯📯 Chemical Biology starter pack 📯📯 140 PIs & groups posting primary research in chemical biology. Please reskeet (?) & reply to this post if you want to be added! go.bsky.app/KLrTWoj Let's make ChemBioSky even greater again! #realtimechem #FluorescenceFriday #chemsky #chemtwitter #AgentOrange

48138115

Byron Purse @byronpurse.bsky.social · 14/11/2024

The Department of #Chemistry and #Biochemistry at #SDSU is currently accepting applications for Fall 2025 for our #PhD, #MS, and #MA programs. Please tell interested students, repost & spread the word! tinyurl.com/vwxtvbxv

000