iiinova — where your digital self keeps evolving

Büşra Savaş @busrasavas.bsky.social · 21/09/2026

Some news taste better after a little marination 🎓 After a reviving summer, I’m happy to finally share that I’ve successfully defended my PhD in late March!

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Ezgi Karaca @ezgikaraca.bsky.social · 27/03/2026

Only a couple of days left to introduce our brand new tool, DynaPIN that @aysebercinb.bsky.social developed (in collaboration with @sacquin-mo.bsky.social & co.) to analyze dynamic/ensemble protein interfaces!

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BioExcel CoE @bioexcelcoe.bsky.social · 18/03/2026

Join us in a couple of weeks to hear @ezgikaraca.bsky.social talk about "DynaPIN: a tool for characterising dynamic protein interfaces" 🗓️ 31 March 2026, 15:00 CET ✍️ bioexcel.eu/lgmq #webinar #ComputerSimulation #protein #molecularmodeling

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Büşra Savaş @busrasavas.bsky.social · 09/02/2026

🚀 Excited to announce that our perspective piece with @ezgikaraca.bsky.social and @aysebercinb.bsky.social on AlphaFold distograms is now published in @febsletters.bsky.social!! Here is what we did further 👇

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Büşra Savaş @busrasavas.bsky.social · 11/12/2025

364 days a year we use AlphaFold to predict protein structure… But not on Christmas Eve! That’s when Santa does the predictions. But beware, computational structural biologists on the naughty list will only get low pLDDTs #SantaFold #bananapro

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A. Berçin Barlas @aysebercinb.bsky.social · 22/08/2025

🚀 Excited to share that our article with @ezgikaraca.bsky.social is now published in Communications Biology! In this study, we explored DNA readout rules of almost identical DNMT3A and DNMT3B (91% sequence similarity!), and we asked: how can nearly the same proteins “see” DNA so differently? 🧬✨

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Ezgi Karaca @ezgikaraca.bsky.social · 29/07/2025

We just bumped into something very preliminary… but very exciting: AF2.3 and AF3.0 distograms may potentially reproduce MD-like behavior. Until we do further tests, you can reach our early insights at www.biorxiv.org/content/10.1...

biorxiv.org

Exploring the Potential of AlphaFold Distograms for Flexibility Assignment in Cryo-EM Maps

AlphaFold (AF) models are widely used in cryo-EM workflows, but their static structure predictions limit the interpretation of flexible or unresolved regions. To address this, we investigate whether A...

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Büşra Savaş @busrasavas.bsky.social · 29/07/2025

🚨 Super excited for our new preprint on flexibility cues in AlphaFold! Together with @ezgikaraca.bsky.social and @aysebercinb.bsky.social, we found that distograms of AF2.3 and AF3 mirror MD sampling by predicting the extent of a novel conformational change! 🤯 For more👇

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Alexandre Bonvin @amjjbonvin.bsky.social · 29/07/2025

A small reminder to all structural biologists around working on biomolecular complexes: please consider sharing your complexes as targets for CAPRI - AI has not solved all structure prediction problems and there are still challenges! See www.capri-docking.org/contribute/

capri-docking.org

CAPRI Docking

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Ezgi Karaca @ezgikaraca.bsky.social · 11/06/2025

Only a few days left to apply for our EMBO course with a great lineup of speakers and tutors! Please feel free to RT! Course website: meetings.embo.org/event/25-bio... Organizers: myself, @amjjbonvin.bsky.social @bioinfo.se @lindorfflarsen.bsky.social Location: www.ibg.edu.tr

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Büşra Savaş @busrasavas.bsky.social · 22/05/2025

We want awe. We want discovery. And we want them now! Huge thanks to Itai and Martin for the most enjoyable lecture on Night Science — a reminder that opennes lie at the heart of discovery!

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Greenlab Zürich @greenlabzh.bsky.social · 06/05/2025

This week's #SustainableTipTuesday is about computation - did you know there is a version of AlphaFold that uses 95% less energy than the regular version? Take a look below💡 #greenlabs

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Ezgi Karaca @ezgikaraca.bsky.social · 22/02/2025

Inspired by Wallner's AFsample approach, @busrasavas.bsky.social's MinnieFold produced good quality antibody-antigen models even with 95% reduced sampling over CAPRI55 targets. Just accepted in Proteins! Paper: www.biorxiv.org/content/10.1... Github: github.com/CSB-KaracaLa...

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Ezgi Karaca @ezgikaraca.bsky.social · 02/01/2025

The legendary EMBO Integrative Modeling Course is back! If you want to be in this picture in the 2025 edition, just go ahead and register at meetings.embo.org/event/25-bio... Organized by myself & @amjjbonvin.bsky.social & @arneelof.bsky.social & @lindorfflarsen.bsky.social

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Ezgi Karaca @ezgikaraca.bsky.social · 13/01/2024

Super proud to have been listed as one of the successful groups in predicting the structure of an antibody-peptide during @capridock.bsky.social's 55th round! This was our first attempt in CAPRI as the Karaca team with @busrasavas.bsky.social @iremylmazbilek.bsky.social @atakanozsan 💪

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