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Danilo Buonsenso

@buonsenso.bsky.social
3.8K followers 102 following 536 posts

Pediatric Infectious Disease doctor. Fighting to care for children with Long Covid & ME/CFS. My book on my LONG COVID JOURNEY: tinyurl.com/4tsvhwat

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Danilo Buonsenso @buonsenso.bsky.social · 12/04/2026
Post-Viral ME/CFS with POTS in a Pediatric Patient: A Case Report danilobuonsenso.substack.com/p/post-viral...
danilobuonsenso.substack.com
Post-Viral ME/CFS with POTS in a Pediatric Patient: A Case Report
Abstract
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Danilo Buonsenso @buonsenso.bsky.social · 12/04/2026
that was in my book already
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Danilo Buonsenso @buonsenso.bsky.social · 12/04/2026
this is a case I diagnosed and I gave indication for ivig. than I was not involved in the paper but that’s another thing. anyway the patient is fine although the key point is that I diagnosed him at 4 months of disease so treatment was started very early
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Danilo Buonsenso @buonsenso.bsky.social · 12/04/2026
this is a case I diagnosed and I gave indication for ivig. than I was not involved in the paper but that’s another thing. anyway the patient is fine although the key point is that I diagnosed him at 4 months of disease so treatment was started very early
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Danilo Buonsenso @buonsenso.bsky.social · 22/03/2026
14yro with Long Covid treated with ivabradine and anticoagulation danilobuonsenso.substack.com/p/14yro-with...
danilobuonsenso.substack.com
14yro with Long Covid treated with ivabradine and anticoagulation
BEFORE YOU READ:
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Danilo Buonsenso @buonsenso.bsky.social · 08/03/2026
CASE REPORT - A neuroscientist with Long Covid on low dose rapamycine danilobuonsenso.substack.com/p/case-repor...
danilobuonsenso.substack.com
CASE REPORT - A neuroscientist with Long Covid on low dose rapamycine
Welcome to a new real life case report.
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Danilo Buonsenso @buonsenso.bsky.social · 01/02/2026
A Pathogenic Monocyte Signature in Long COVID: What It Means for Buonsenso and the Kids danilobuonsenso.substack.com/p/a-pathogen...
danilobuonsenso.substack.com
A Pathogenic Monocyte Signature in Long COVID: What It Means for Buonsenso and the Kids
Long COVID has puzzled scientists, clinicians, and families alike for years — especially when children and adolescents continue to struggle with fatigue, shortness of breath, and other persistent symp...
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Reposted by Danilo Buonsenso
Long Covid Kids @longcovidkids.bsky.social · 29/01/2026
"These findings reinforce an urgent message that children and adolescents can develop #LongCovid not only after an initial infection, but also after reinfection. The public health implications are substantial." @buonsenso.bsky.social www.thelancet.com/journals/lan... #LongCovidKids #Children
thelancet.com
Long COVID is here to stay—even in children
Post-acute sequelae of SARS-CoV-2 infection (PASC, also known as long COVID) are complex, multisystem, long-lasting complications of SARS-CoV-2 infection that profoundly impact the daily life of those...
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Reposted by Danilo Buonsenso
valebodi.bsky.social @valebodi.bsky.social · 29/01/2026
Long COVID is here to stay—even in children 😢 @buonsenso.bsky.social These findings reinforce an urgent message that children and adolescents can develop long COVID not only after an initial infection, but also after reinfection. The public health implications are substantial. Before this study,
thelancet.com
Long COVID is here to stay—even in children
Post-acute sequelae of SARS-CoV-2 infection (PASC, also known as long COVID) are complex, multisystem, long-lasting complications of SARS-CoV-2 infection that profoundly impact the daily life of those...
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Danilo Buonsenso @buonsenso.bsky.social · 25/01/2026
Plasmapheresis, apheresis, and why people with Long Covid or ME/CFS talk about them danilobuonsenso.substack.com/p/plasmapher...
danilobuonsenso.substack.com
Plasmapheresis, apheresis, and why people with Long Covid or ME/CFS talk about them
as we are implementing a protocol for plasmapheresis in patients with Long Covid and ME/CFS, I wanted to summarize with you what it is and why we are thinking about that.
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Danilo Buonsenso @buonsenso.bsky.social · 18/01/2026
Long COVID: When the Fire Inside Never Turns Off — A Personal Reflection danilobuonsenso.substack.com/p/long-covid...
danilobuonsenso.substack.com
Long COVID: When the Fire Inside Never Turns Off — A Personal Reflection
Every parent wants their child to be healthy and whole.
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Danilo Buonsenso @buonsenso.bsky.social · 10/01/2026
after years of illness and gaslighting, this kid with #LongCovid is leaving again❤️ grateful for this mum’s email. Why IVIG and immunemodulation work most time is written since two years in my book tinyurl.com/4tsvhwat and blog substack.com/@mecfslongco...
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Danilo Buonsenso @buonsenso.bsky.social · 04/01/2026
where?
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Danilo Buonsenso @buonsenso.bsky.social · 04/01/2026
Energy Metabolism and Immune Signatures in ME/CFS: What the Latest Paper Means for Kids and Families danilobuonsenso.substack.com/p/abnormal-e...
danilobuonsenso.substack.com
Abnormal Energy Metabolism and Immune Signatures in ME/CFS: What the Latest Paper Means for Kids and Families
Chronic fatigue syndrome (ME/CFS) remains one of the most puzzling, debilitating disorders in medicine — especially when it affects children and adolescents.
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Danilo Buonsenso @buonsenso.bsky.social · 28/12/2025
Long COVID, Immune Dysregulation & What It Means for Kids — New Insights and Future Therapies danilobuonsenso.substack.com/p/long-covid...
danilobuonsenso.substack.com
Long COVID, Immune Dysregulation & What It Means for Kids — New Insights and Future Therapies
Long COVID isn’t just a collection of lingering symptoms — it may reflect deep changes in the immune system that can persist for years.
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Danilo Buonsenso @buonsenso.bsky.social · 22/12/2025
When I started the #longcovid in kids journey we were literally alone. Now, we arrived to speak about long covid in children in @TheLancetInfDis Podcast!❤️ MY LONG COVID JOURNEY, WHAT I DO AND WHY IN MY BOOK: tinyurl.com/4tsvhwat 🔊 Spotify: bit.ly/4p7jnpy
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Danilo Buonsenso @buonsenso.bsky.social · 14/12/2025
You Are Not Alone – Let’s Connect Families, Young People and Communities Living with Long Covid and ME/CFS danilobuonsenso.substack.com/p/you-are-no...
danilobuonsenso.substack.com
You Are Not Alone – Let’s Connect Families, Young People and Communities Living with Long Covid and ME/CFS
When a child, teenager, or young adult develops Long Covid or ME/CFS, the world can suddenly become very small.
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Danilo Buonsenso @buonsenso.bsky.social · 14/12/2025
a new major study on Nature immunology further reinforces the overwhelming evidence of chronic immune activation in #longcovid, perfectly justifying off label use of immune modulators (eg IVIG) in the most severe cases that cannot access trials. Saying since a few years in my book lnkd.in/dPHkH3re
lnkd.in
LinkedIn
This link will take you to a page that’s not on LinkedIn
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Danilo Buonsenso @buonsenso.bsky.social · 09/12/2025
So the Pediatric Infectious Diseases games are ready to go in 2d! Impressive amount of different european countries participating this year!
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Danilo Buonsenso @buonsenso.bsky.social · 07/12/2025
I know, in these cases it’s not worth it
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Danilo Buonsenso @buonsenso.bsky.social · 07/12/2025
When Patients Ask for a Cure: A Doctor’s Honest Reflection on Long Covid and ME/CFS danilobuonsenso.substack.com/p/when-patie...
danilobuonsenso.substack.com
When Patients Ask for a Cure: A Doctor’s Honest Reflection on Long Covid and ME/CFS
In the past months, my inbox (and whatsapp!) has filled with messages from patients and families living with Long Covid or ME/CFS.
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Danilo Buonsenso @buonsenso.bsky.social · 30/11/2025
Oxaloacetate, long COVID and ME/CFS: what the new trial shows — and a pragmatic (non-prescriptive) scheme for clinicians danilobuonsenso.substack.com/p/oxaloaceta...
danilobuonsenso.substack.com
Oxaloacetate, long COVID and ME/CFS: what the new trial shows — and a pragmatic (non-prescriptive) scheme for clinicians
Fatigue and cognitive fog remain among the most disabling complaints for people with long COVID and with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).
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Danilo Buonsenso @buonsenso.bsky.social · 23/11/2025
let us know
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Danilo Buonsenso @buonsenso.bsky.social · 23/11/2025
with the only and one!!
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Danilo Buonsenso @buonsenso.bsky.social · 23/11/2025
Low-Dose Rapamycin for ME/CFS and Long COVID: New Clinical Data, Promising Hints, and Ongoing Caution danilobuonsenso.substack.com/p/low-dose-r...
danilobuonsenso.substack.com
Low-Dose Rapamycin for ME/CFS and Long COVID: New Clinical Data, Promising Hints, and Ongoing Caution
Over the past months, I have written several posts exploring the potential role of low-dose rapamycin in Long COVID and ME/CFS (Part 1, Part 2, Part 3).
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Danilo Buonsenso @buonsenso.bsky.social · 16/11/2025
What’s new in the Long COVID / ME/CFS endothelial story — and what that means for treatment danilobuonsenso.substack.com/p/whats-new-...
danilobuonsenso.substack.com
What’s new in the Long COVID / ME/CFS endothelial story — and what that means for treatment
You may remember that in earlier posts we discussed how both Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) appear to share a key feature: endothelial inflammation/dysfunct...
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Danilo Buonsenso @buonsenso.bsky.social · 14/11/2025
you’ll read several success papers about #nirsevimab and #RSV but to make it a successful and long term sustainable interventions you need to read also of out chorus provocative voices, like this one ! rdcu.be/ePXTa
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Danilo Buonsenso @buonsenso.bsky.social · 09/11/2025
Long COVID and the AMPA Pathway: New Clues from Brain Imaging danilobuonsenso.substack.com/p/long-covid...
danilobuonsenso.substack.com
Long COVID and the AMPA Pathway: New Clues from Brain Imaging
Over the past few years, Long COVID has become one of the most puzzling and impactful conditions in post-viral medicine — especially for the many children and adults who continue to experience “brain ...
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Danilo Buonsenso @buonsenso.bsky.social · 03/11/2025
Conversations on IVIG and Monoclonals in #LongCovid #MECFS danilobuonsenso.substack.com/p/conversati...
danilobuonsenso.substack.com
Conversations on IVIG and Monoclonals
A recording from MD, PhD's live video
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Danilo Buonsenso @buonsenso.bsky.social · 01/11/2025
new on covid impact on kids www.tandfonline.com/eprint/ZY2VI...
tandfonline.com
The second-order effects that the COVID-19 pandemic has had on pediatric populations
SARS-CoV-2 can have long-term health consequences that persist beyond acute infection. While this is evident in adults and the elderly, the impact on children and adolescents remains under recogniz...
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Danilo Buonsenso @buonsenso.bsky.social · 01/11/2025
retweeting allows direct engagement
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Reposted by Danilo Buonsenso
Amy 🌤️ @cloudsandsunshine.bsky.social · 26/10/2025
The latest from @buonsenso.bsky.social rings so true: Yet when patients and families ask for treatments, the answer is almost always: “There are no approved options.” open.substack.com/pub/danilobu... #PedSky #LongCovidKids #pwLC #pwME
open.substack.com
When There Are No Treatments: Why Off-Label Drugs Should Be on the Table for Long Covid and ME/CFS
What Does “Off-Label” Really Mean?
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Danilo Buonsenso @buonsenso.bsky.social · 22/10/2025
glad our team contributed to another very important study on iGAS. PEGASUS network www.sciencedirect.com/science/arti...
sciencedirect.com
Paediatric invasive group A streptococcal infections and associations with viral infections in 15 European countries after lifting non-pharmaceutical interventions against SARS-CoV-2: an interrupted t...
After lifting non-pharmaceutical interventions (NPIs) against the transmission of SARS-CoV-2, various countries experienced an increase in invasive Gr…
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Danilo Buonsenso @buonsenso.bsky.social · 19/10/2025
“We Can’t Do This Alone”: A Doctor’s Plea for Support in Caring for Long COVID and ME/CFS Patients danilobuonsenso.substack.com/p/we-cant-do...
danilobuonsenso.substack.com
“We Can’t Do This Alone”: A Doctor’s Plea for Support in Caring for Long COVID and ME/CFS Patients
As a pediatrician and infectious disease specialist, my days are full.
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Danilo Buonsenso @buonsenso.bsky.social · 15/10/2025
again viruses and dementia. those of you negating this slow science progression and patients prevention options. all started w #LongCovid revolution. years ago I said LC is clearly giving this indication and now science is confirming all in my book: tinyurl.com/4tsvhwat
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Danilo Buonsenso @buonsenso.bsky.social · 12/10/2025
Working (and Keeping Your Salary) When Long COVID or ME/CFS Makes Full-Time Work Impossible danilobuonsenso.substack.com/p/working-an...
danilobuonsenso.substack.com
Working (and Keeping Your Salary) When Long COVID or ME/CFS Makes Full-Time Work Impossible
1.
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Danilo Buonsenso @buonsenso.bsky.social · 08/10/2025
I have a strongest feeling and growing evidence that lung ultrasound will play a growing role not only in diagnosing pneumonia but also in understanding which cases need antibiotics rdcu.be/eJ1tQ
rdcu.be
Point-of-care lung ultrasound to differentiate bacterial and viral lower respiratory tract infections in pediatric age: a multicenter prospective observational study
Scientific Reports - Point-of-care lung ultrasound to differentiate bacterial and viral lower respiratory tract infections in pediatric age: a multicenter prospective observational study
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Danilo Buonsenso @buonsenso.bsky.social · 05/10/2025
Can IV Saline Help Kids and Adults with ME/CFS? danilobuonsenso.substack.com/p/can-iv-sal...
danilobuonsenso.substack.com
Can IV Saline Help Kids and Adults with ME/CFS?
Living with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) can be exhausting, not only because of the illness itself but also because of the limited treatment options available.
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Danilo Buonsenso @buonsenso.bsky.social · 02/10/2025
glad @TheLancetInfDis gave #LongCovid kids the voice they deserve, and with a powerful title as I love. that’s a big change compared with the past t.co/TyOo8jmQOr
t.co
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(25)00496-7/fulltext
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Reposted by Danilo Buonsenso
Long Covid Kids @longcovidkids.bsky.social · 02/10/2025
The Lancet @buonsenso.bsky.social The take-home message from this study is clear: long COVID is here to stay, even in children, and can be exacerbated by reinfections and sustained by high viral circulation. Governments, health-care systems, and #LongCovidKids www.thelancet.com/journals/lan...
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Danilo Buonsenso @buonsenso.bsky.social · 28/09/2025
Helping Your Child Through Long Covid or ME/CFS: What Parents Can Do, Age by Age danilobuonsenso.substack.com/p/helping-yo...
danilobuonsenso.substack.com
Helping Your Child Through Long Covid or ME/CFS: What Parents Can Do, Age by Age
Long Covid and ME/CFS can affect children, adolescents, and young adults in profoundly different ways.
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Danilo Buonsenso @buonsenso.bsky.social · 21/09/2025
Nasal Azelastine and COVID Prevention: What a New Study Tells Us — And Why It Might Matter for Long COVID / ME/CFS danilobuonsenso.substack.com/p/nasal-azel...
danilobuonsenso.substack.com
Nasal Azelastine and COVID Prevention: What a New Study Tells Us — And Why It Might Matter for Long COVID / ME/CFS
Introduction
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Danilo Buonsenso @buonsenso.bsky.social · 19/09/2025
one of the best feedback I could receive, mostly from the emotional perspective. you can join the discussion on #ivig for #LongCovid or #mecfs on my blog open.substack.com/pub/danilobu...
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Danilo Buonsenso @buonsenso.bsky.social · 15/09/2025
this message tells a lot about #LongCovid 1- pts recognized soon can recove, also entirely 2- reinfections can bring you doing again this means a general predisposition against over reaction to viral infection, but also to try to avoid reinfections and maybe to treat them
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Danilo Buonsenso @buonsenso.bsky.social · 15/09/2025
so true
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Danilo Buonsenso @buonsenso.bsky.social · 15/09/2025
agree, written this open.substack.com/pub/danilobu...
open.substack.com
Could Intravenous Immunoglobulin (IVIG) Help in Long Covid and ME/CFS?
A clinical overview for families and physicians — by Buonsenso and the Kids
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Reposted by Danilo Buonsenso
Alex @admiringbog.bsky.social · 14/09/2025
When I was a teenager, an early diagnosis and good advice would have been life changing.
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Danilo Buonsenso @buonsenso.bsky.social · 14/09/2025
What Is ME/CFS — And Why Should Pediatricians Care? danilobuonsenso.substack.com/p/what-is-me...
danilobuonsenso.substack.com
What Is ME/CFS — And Why Should Pediatricians Care?
ME/CFS is a complex, multi-system chronic illness that can strike both adults and children.
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Danilo Buonsenso @buonsenso.bsky.social · 09/09/2025
dear patients with #LongCOVID #MECFS , parents, the journey is not easy and we don’t always find the best solution soon, but please don’t give up, being better is possible!! more in my blog: danilobuonsenso.substack.com book: tinyurl.com/4tsvhwat
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Danilo Buonsenso @buonsenso.bsky.social · 08/09/2025
Is My Child Just Tired — or Is It Something More? danilobuonsenso.substack.com/p/is-my-chil...
danilobuonsenso.substack.com
Is My Child Just Tired — or Is It Something More?
What Every Parent Should Know About Post-Viral Fatigue and Long Covid
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