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The bumbling biochemist (Bri Bibel)

@bumblingbiochemist.bsky.social
610 followers 671 following 1.3K posts

Assistant Prof of Biochemistry & Chemistry @ LMU | Metabolic enzymes of bioremediating bacteria. Making biochemistry fun & accessible #biochemsky #chemsky thebumblingbiochemist.com & www.youtube.com/@thebumblingbiochem…

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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 15h
Another installment of demystifying the hidden curriculum of academic science, this one scheduled purposefully to round out the American Society for Biochemistry and Molecular Biology (ASBMB)'s @asbmb.bsky.social #MolecularBioscienceWeek thebumblingbiochemist.com/365-days-of-...
thebumblingbiochemist.com
Who’s who (position-wise) in academic science labs – The Bumbling Biochemist
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 15h
Behind every scientific discovery is a "village" so to speak - here's a guide to who's inside – and outside – of academic labs helping research happen (PI, students, postdocs, lab technicians, lab managers, etc.). And what's involved if you're hoping to get involved! youtu.be/xbMMbe2MyYg
youtu.be
Who's who inside & outside of academic labs helping research happen (PI, students, postdocs, etc.)
YouTube video by the bumbling biochemist
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 09/10/2026
Next week, it's hopefully back on crystal harvest wise! 🤞 this dewar holds LN2 over the weekend so I can trust it... youtu.be/8GC9JRKPhIc
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Hopefully back in the game - next week, it's on!
YouTube video by the bumbling biochemist
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 08/10/2026
Chirality in biological molecules - Nobel prizes & enzymes youtu.be/DK-NSgkeEM0 #MolecularBioscienceWeek
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Chirality in biological molecules - Nobel prizes & enzymes
YouTube video by the bumbling biochemist
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 07/10/2026
Why and how we purify proteins with FPLC (aka - what's an AKTA and why should I care?) In honor of @asbmb.bsky.social #MolecularBioscienceWeek, Korina and Ryan wanted to tell y'all! youtu.be/uhfrn6dpLpM
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Why and how we purify proteins with FPLC (aka - what's an AKTA and why should I care?)
YouTube video by the bumbling biochemist
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 06/10/2026
What better way to kickstart #MolecularBioscienceWeek?! Back in the crystallography game! More easily this time thanks to screens + optimization youtube.com/shorts/OigSF...
youtube.com
Back in the crystallography game! More easily this time thanks to screens + optimization
YouTube video by the bumbling biochemist
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 04/10/2026
thebumblingbiochemist.com/365-days-of-...
thebumblingbiochemist.com
Solid-state oligonucleotide synthesis: phosphoramidite method
Phosphoramidite is pretty cool - am I right or am I right? It helps us DNA or RNA write! Solid-state oligonucleotide synthesis, including the phosphoramidite method, can be used by companies to make l...
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 04/10/2026
Ever wonder how oligonucletides are synthesized? youtu.be/K63iefEOBh0
youtu.be
Solid state oligonucleotide synthesis – phosphoramidite method
YouTube video by the bumbling biochemist
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 03/10/2026
More trainee-related content: bit.ly/gradpostdocetc & YouTube playlists: youtube.com/playlist?lis...
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 03/10/2026
Resilience is crucial to research. Science is a rollercoaster of emotional ups and downs. Don’t let the downs keep you down. Try to learn whatever you can from the downs, but don’t get stuck in them. youtube.com/shorts/VOGAz...
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The importance of resilience in science
YouTube video by the bumbling biochemist
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 03/10/2026
Down but not out – dewar disaster update . . . youtube.com/shorts/_SqrC...
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Down but not out – dewar disaster update . . .
YouTube video by the bumbling biochemist
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 01/10/2026
Crystallographer's nightmare . . . We got sent a defective liquid nitrogen dewar - came to lab this morning and found it dry with 4 unipucks worth of crystals we’d worked months on and harvested Tuesday – my lab’s first… youtube.com/shorts/f0iSj...
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Crystallographer’s worst nightmare…
YouTube video by the bumbling biochemist
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 01/10/2026
Cryoprotecting crystals – how I like to do it... youtu.be/4veDrwz8EHg
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Cryoprotecting crystals – how I like to do it...
YouTube video by the bumbling biochemist
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 30/09/2026
Thank you!!!!!!!! More about their visit: bibellab.lmu.build/whats-news/
bibellab.lmu.build
What’s new(s) – The Bibel Lab @ LMU
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 30/09/2026
Today was a huge milestone for the Bibel lab – our 1st protein crystal harvest for x-ray crystallography! Aided by world experts from the National Crystallization Center (NCC) – Drs. Sarah Bowman and Gabby Budziszewski! @xtalmaker.bsky.social & @gabbygrowsxtals.bsky.social @getacrystal.bsky.social
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 29/09/2026
You can learn more about the first annual Molecular Bioscience Week and get involved here: www.asbmb.org/molecular-bi...
asbmb.org
Molecular Bioscience Week
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 29/09/2026
Why Molecular Bioscience matters – from the lens of Bibel lab members in a ramp-up to @asbmb.bsky.social #MolecularBioscienceWeek youtube.com/shorts/ZYWed...
youtube.com
Why Molecular Bioscience matters – from the lens of Bibel lab members #MolecularBioscienceWeek
YouTube video by the bumbling biochemist
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 27/09/2026
Much more here: bit.ly/mutation_terms
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 27/09/2026
Sometimes I just really need to geek out . . . So, let's talk terms. Because synonymous & silent are not synonyms! youtu.be/hx83xrlGQ1s
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Silent vs. synonymous mutations - they’re not the same thing!
YouTube video by the bumbling biochemist
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 26/09/2026
This will allow you to read & interpret sequences with ease, recognize the potential impact of various substitutions coming from mutations, etc. It’s a lot, I know, but it’s soooo worth it. So here’s a downloadable guide to hopefully help thebumblingbiochemist.com/lets-talk-sc...
thebumblingbiochemist.com
Amino acids
From amino acids to peptides to proteins: an overview How proteins take shape - amino acids, peptide bonds, & layers of protein structure Biochemistry from A to Z! Remember, amino acid...
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 26/09/2026
Learning your amino acids (abbreviations and properties) is one of the most important and empowering things you can do biochemistry-wise. It turns a string of letters from gibberish into a comprehendible key to a molecular world. youtu.be/duIF1N57Q6M
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Key information to know about amino acids & tips for remembering
YouTube video by the bumbling biochemist
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 25/09/2026
One of the most important reasons to learn your amino acids? To read biochemical shorthand! bit.ly/mutation_terms
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 25/09/2026
We're not just being mean when we make our students learn their amino acids - we're equipping them with a magical decoder ring for the molecular world! youtu.be/CWwVmdR6h-U
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Protein variant amino acid nomenclature – shorthand for representing substitutions, deletions, etc.
YouTube video by the bumbling biochemist
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 25/09/2026
One of my favorite parts of teaching undergrads in the lab is introducing them to lab tricks. And I've got a lot more . . . More random practical lab tips & tricks: bit.ly/lab_tricks_p...  & www.youtube.com/playlist?lis...
bit.ly
Random practical lab tips & tricks
Want the greatness of glycerol without the gunk? Try preparing an 80% glycerol solution. It’s way easier to work with! Here’s a practical look at how you can do it. https://www.youtube.com/watc...
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 25/09/2026
Practical lab tip - you can measure the approximate volume of liquid in a microcentrifuge tube or similar with a pipet. youtube.com/shorts/LEpJy...
youtube.com
Quick tip for measuring small volumes (approximately)
YouTube video by the bumbling biochemist
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 23/09/2026
thebumblingbiochemist.com/fplc-akta-pr...
thebumblingbiochemist.com
FPLC (AKTA) practical tutorials
Much more on protein purification on the protein expression and purification page! YouTube playlist Meet the AKTA! A quick tour of the basics of an FPLC (Fast Protein Liquid Chromatography) sys...
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 23/09/2026
When you have so much protein that a single pre-packed chromatography column won't do, just go ahead and link together 2! youtu.be/QY-np2475jY
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Linking together pre-packed FPLC columns to increase column volume
YouTube video by the bumbling biochemist
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 20/09/2026
bit.ly/pdbstructures
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 20/09/2026
What PDB "chains" are and how to work with them in the PDB and PyMOL youtu.be/SVUzFO1rnZ0
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What PDB "chains" are and how to work with them in the PDB and PyMOL
YouTube video by the bumbling biochemist
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 20/09/2026
thebumblingbiochemist.com/365-days-of-...
thebumblingbiochemist.com
Basics of UniProt, ProtParam & other free online database tools every protein biochemist "needs"
https://www.youtube.com/watch?v=f75f6QCe1gA https://youtu.be/f75f6QCe1gA The protein biochemist’s toolbox almost definitely includes UniProt & ProtParam. So here are some of the basics of using the...
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 20/09/2026
New downloadable guide: UniProt and the PDB: A frequent user’s guide inside. This one goes beyond my fundamentals guide. Hope it’s helpful! youtu.be/q4gwtVxnP5o
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New downloadable guide: UniProt and the PDB: A frequent user’s guide inside
YouTube video by the bumbling biochemist
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 19/09/2026
bit.ly/uniprotprotp...
bit.ly
Basics of UniProt, ProtParam & other free online database tools every protein biochemist "needs"
https://www.youtube.com/watch?v=f75f6QCe1gA https://youtu.be/f75f6QCe1gA The protein biochemist’s toolbox almost definitely includes UniProt & ProtParam. So here are some of the basics of using the...
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 19/09/2026
Mix things up - the right way! youtube.com/shorts/TbSNH...
youtube.com
Mix things up - the right way!
YouTube video by the bumbling biochemist
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 19/09/2026
Can’t believe it was a full year ago when I attended my first LMU Seaver meeting! Still incredibly grateful to be here!!!!!!
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 18/09/2026
bibellab.lmu.build
bibellab.lmu.build
The Bibel Lab @ LMU – Investigating metabolic adaptations of metal-remediating microbes
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 18/09/2026
Say hi to Jackson Spiecker, the newest member of the Bibel lab! We're thrilled to welcome Jack to our group (joining an awesome crew of undergrads – Korina, Liam, Ryan, Brooke, and Alvie)! I took the opportunity to revamp the site where you can learn more about us all.
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 17/09/2026
In preparation of teaching a bioinformatics lab next week, I updated my PyMOL (molecular visualization software program) resources page including a PDF guide to PyMOL fundamentals. Hope it’s helpful! thebumblingbiochemist.com/365-days-of-...
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 16/09/2026
Peristaltic pumps for protein chromatography – a middle ground between gravity flow & FPLC youtu.be/sGBoaGurU6E
youtu.be
Peristaltic pumps for protein chromatography – a middle ground between gravity flow & FPLC
YouTube video by the bumbling biochemist
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 15/09/2026
Hope it's helpful! bit.ly/uniprotprotp...
bit.ly
Basics of UniProt, ProtParam & other free online database tools every protein biochemist "needs"
https://www.youtube.com/watch?v=f75f6QCe1gA https://youtu.be/f75f6QCe1gA The protein biochemist’s toolbox almost definitely includes UniProt & ProtParam. So here are some of the basics of using the...
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 15/09/2026
Downloadable guide on fundamentals of UniProt and the PDB youtube.com/shorts/fI4Ce...
youtube.com
Guide on fundamentals of UniProt and the PDB
YouTube video by the bumbling biochemist
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 13/09/2026
Why PDB entries might contain more or less than you'd expect and how to choose which one to use youtu.be/m6JghrH6wBM
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Why PDB entries might contain more or less than you'd expect and how to choose which one to use
YouTube video by the bumbling biochemist
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 13/09/2026
Which PDB structure to choose? Why do some look different than what you expect? Here's the gist . . .
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 11/09/2026
These and more pipetting tips: bit.ly/pipetposts
bit.ly
Pipette like a pro!
For more on types of pipets, see this comprehensive post For more on pipetting viscous liquids, see this post For more on pipetting volatile liquids, see this post For more ...
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 11/09/2026
Don't stop pipetting . . . But do stop at the correct stops! Tips for proper pipetting thumbmanship youtu.be/kX-rknPb7WI
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Don't stop pipetting . . . But do stop at the correct stops! Tips for proper pipetting thumbmanship
YouTube video by the bumbling biochemist
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 10/09/2026
bit.ly/bbbookrecs
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 10/09/2026
New book for my all-time faves list – Curved Air: A Biography of Sickle Cell Anemia and the Quest to Cure the First Molecular Disease by Kevin Davies, 2026 youtu.be/BtplT89IpYc
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Book rec: A Bio of Sickle Cell Anemia & the Quest to Cure the 1st Molecular Disease by Kevin Davies
YouTube video by the bumbling biochemist
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 09/09/2026
Crystal fishing/harvesting practice - behind the scenes... youtu.be/5rTF1htelOQ
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Crystal fishing/harvesting practice - behind the scenes
YouTube video by the bumbling biochemist
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 07/09/2026
Here's a quick walk-through of what you'll find: youtu.be/tDvtV4tVDC8
youtu.be
Recombinant protein methods page
YouTube video by the bumbling biochemist
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 07/09/2026
The bumbling biochemist’s guide to recombinant protein work is live! This page has an overview of recombinant protein techniques, from molecular cloning to expression, purification, & characterization. complete with graphics, links, and a downloadable PDF thebumblingbiochemist.com/recombinantm...
thebumblingbiochemist.com
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The bumbling biochemist (Bri Bibel) @bumblingbiochemist.bsky.social · 06/09/2026
PS - I’m still working on making a whole blog page version with graphics, but for now, you can find and download the PDF here: thebumblingbiochemist.com/lets-talk-sc...
thebumblingbiochemist.com
Protein expression and purification
Downloadable guide Recombinant_Protein_Methods_GuideDownload Overview graphics YouTube playlists Molecular cloning: https://youtube.com/playlist?list=PLUWsCDtjESrESdmbn...
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