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Reposted by Jess Buddle

Rob Fagan @robfagan.bsky.social · 22/08/2025

New preprint from us! The latest part of our C. difficile vancomycin resistance story. We identified a new two-component system (VnrRS) that can control expression of the vanG pathway - just needs one amino acid change @buddlejess.bsky.social @brockhurstlab.bsky.social @claireyt.bsky.social

biorxiv.org

A novel two-component system controls vancomycin resistance in epidemic Clostridioides difficile

The glycopeptide antibiotic vancomycin is the frontline treatment for C. difficile infection in the UK. There have been only sporadic reports of resistance in the clinic but testing is rare so the tru...

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