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Eduardo Bruera

@brueraeduardo.bsky.social
638 followers 514 following 1.1K posts

Chair, Department of Palliative, Rehabilitation and Integrative Medicine, The University of Texas MD Anderson Cancer Center

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Eduardo Bruera @brueraeduardo.bsky.social · 14h
Older members do not work less: they work differently!
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Eduardo Bruera @brueraeduardo.bsky.social · 02/10/2026
Olanzapine therapy should be reviewed regularly as patients move beyond active cancer treatment. Decisions should be individualized and should balance current symptom burden, patient priorities, and the potential for long-term metabolic harm. pubmed.ncbi.nlm.nih.gov/42822791/
pubmed.ncbi.nlm.nih.gov
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Eduardo Bruera @brueraeduardo.bsky.social · 27/09/2026
Prescription Monitoring Programs alone miss most non-medical opioid use in cancer patients; comprehensive clinical review is essential for assessing opioid risk. (154 characters) pubmed.ncbi.nlm.nih.gov/42543383/
pubmed.ncbi.nlm.nih.gov
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Eduardo Bruera @brueraeduardo.bsky.social · 25/09/2026
rapid intravenous opioid titration was associated with substantial symptom improvement, high patient satisfaction, and a low rate of clinically relevant adverse events during titration and the subsequent 20-min observation period pubmed.ncbi.nlm.nih.gov/42776359/
pubmed.ncbi.nlm.nih.gov
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Eduardo Bruera @brueraeduardo.bsky.social · 23/09/2026
DR in oncology is influenced by clinical outcomes and quality of the decision-making process. Greater emphasis on shared decision-making, communication and expectation management may help reduce DR and improve patient-centred cancer care pubmed.ncbi.nlm.nih.gov/42772893/
pubmed.ncbi.nlm.nih.gov
Decisional regret in oncology: a scoping review - PubMed
DR in oncology is influenced by clinical outcomes and quality of the decision-making process. Greater emphasis on shared decision-making, communication and expectation management may help reduce DR and improve patient-centred cancer care.<b>Keywords:</b> Decisional regret, cancer, decision regret sc …
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Eduardo Bruera @brueraeduardo.bsky.social · 22/09/2026
urldefense.com/v3/__https:/...
urldefense.com
#neuropalliative | Canadian Society of Palliative Medicine
If you see patients with ALS or Parkinson's, or want to learn about the latest advancements, Palliative Horizons was designed for you. One day in Vancouver this November. Clinical, practical, and buil...
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Eduardo Bruera @brueraeduardo.bsky.social · 21/09/2026
Cancer patients and caregivers perceived naloxone as beneficial and not likely to cause harm. Agreement between patients and caregivers was only fair, suggesting that better communication regarding naloxone is needed pubmed.ncbi.nlm.nih.gov/42764790/
pubmed.ncbi.nlm.nih.gov
Caregiver perceptions toward naloxone for cancer patients at risk of opioid overdose - PubMed
Cancer patients and caregivers perceived naloxone as beneficial and not likely to cause harm. Agreement between patients and caregivers was only fair, suggesting that better communication regarding naloxone is needed. More research is needed to identify barriers toward safe opioid prescription and i …
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Eduardo Bruera @brueraeduardo.bsky.social · 16/09/2026
Only one in three patients with advanced cancer had an accurate understanding of their curability, with limited improvement over time. Systematic screening may provide opportunities to improve illness understanding and coping support. pubmed.ncbi.nlm.nih.gov/40992638/
pubmed.ncbi.nlm.nih.gov
Systematic Screening of Advanced Cancer Patients' Curability Perception: A Longitudinal Analysis - PubMed
Only one in three patients with advanced cancer had an accurate understanding of their curability, with limited improvement over time. Systematic screening may provide opportunities to improve illness...
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Eduardo Bruera @brueraeduardo.bsky.social · 16/09/2026
This case series highlights the potential use of this combination to reduce suffering and distress secondary to hemoptysis in the palliative setting. pubmed.ncbi.nlm.nih.gov/41207344/
pubmed.ncbi.nlm.nih.gov
Use of Nebulized Tranexamic Acid (TA) in Combination With Nebulized Recombinant Coagulation Factor VIIa to Treat Hemoptysis in Pediatric Patients With Cancer At End-Of-Life (EOL) - PubMed
Hemoptysis is a distressing symptom for both patients and families at end of life (EOL). In the acute care setting, this can be managed surgically or medically. However, research regarding interventions, such as nebulized tranexamic acid (TA) and nebulized factor VIIa, for palliative management of h …
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Eduardo Bruera @brueraeduardo.bsky.social · 16/09/2026
Relative to other analgesics, tramadol is neither superior nor inferior. There may exist a different safety profile and therefore an opportunity to provide individualized patient-centered treatment strategies focused on safety and quality of life pubmed.ncbi.nlm.nih.gov/41324745/
pubmed.ncbi.nlm.nih.gov
The use of tramadol for cancer-associated pain-a systematic review - PubMed
Relative to other analgesics, tramadol is neither superior nor inferior. There may exist a different safety profile and therefore an opportunity to provide individualized patient-centered treatment strategies focused on safety and quality of life.
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Eduardo Bruera @brueraeduardo.bsky.social · 14/09/2026
: Slow iv hydromorphone infusion resulted in similar abuse liability potential and pain improvement but less sedation than fast injection. These findings, suggest that the slow infusion may be considered as a first-line modality for iv opioid administration pubmed.ncbi.nlm.nih.gov/39865340/
pubmed.ncbi.nlm.nih.gov
Abuse potential and analgesic efficacy of intravenous hydromorphone bolus administration among hospitalized patients with cancer pain: A double-blind, double dummy, randomized crossover trial - PubMed
Slow iv hydromorphone infusion resulted in similar abuse liability potential and pain improvement but less sedation than fast injection. These findings, taken together, suggest that the slow infusion may be considered as a first-line modality for iv opioid administration in hospitalized patients req …
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Eduardo Bruera @brueraeduardo.bsky.social · 14/09/2026
During the study period, we observed a five-fold decline in opioid dose prescribed by oncologists for cancer pain. This raises concerns for undertreatment of pain in patients with cancer. pubmed.ncbi.nlm.nih.gov/40138614/
pubmed.ncbi.nlm.nih.gov
Trends in Outpatient Opioid Prescriptions for Cancer Pain Between 2016 and 2021 - PubMed
During the study period, we observed a five-fold decline in opioid dose prescribed by oncologists for cancer pain. This raises concerns for undertreatment of pain in patients with cancer.
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Eduardo Bruera @brueraeduardo.bsky.social · 13/09/2026
pubmed.ncbi.nlm.nih.gov/40526009/
pubmed.ncbi.nlm.nih.gov
Financial Crises Bring Opportunities - PubMed
Financial Crises Bring Opportunities
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Eduardo Bruera @brueraeduardo.bsky.social · 13/09/2026
pubmed.ncbi.nlm.nih.gov/40545622/
pubmed.ncbi.nlm.nih.gov
Breaking free from prognostic paralysis in chronic advanced diseases - PubMed
Breaking free from prognostic paralysis in chronic advanced diseases
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Eduardo Bruera @brueraeduardo.bsky.social · 13/09/2026
pubmed.ncbi.nlm.nih.gov/42576464/
pubmed.ncbi.nlm.nih.gov
Palliative care specialists infrequently discuss driving safety with their patients with cancer when prescribing opioids - PubMed
Opioids may impair the ability to drive especially when prescribed for the first time or when the dose is increased. Because driving is closely associated with independence and quality of life, discus...
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Eduardo Bruera @brueraeduardo.bsky.social · 11/09/2026
pubmed.ncbi.nlm.nih.gov/37525556/
pubmed.ncbi.nlm.nih.gov
Frequency of vaccine hesitancy among patients with advanced cancer - PubMed
Vaccine hesitancy is present among patients with advanced cancer. The high value given to the doctor's recommendation suggests that universal precautions regarding vaccine recommendation may be an effective intervention.
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Eduardo Bruera @brueraeduardo.bsky.social · 11/09/2026
pubmed.ncbi.nlm.nih.gov/37751565/
pubmed.ncbi.nlm.nih.gov
Premonition of Death - PubMed
Premonition of Death
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Eduardo Bruera @brueraeduardo.bsky.social · 11/09/2026
pubmed.ncbi.nlm.nih.gov/35483737/
pubmed.ncbi.nlm.nih.gov
End-of-life care quality metrics in patients with cancer: challenges and opportunities - PubMed
End-of-life care quality metrics in patients with cancer: challenges and opportunities
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Eduardo Bruera @brueraeduardo.bsky.social · 07/09/2026
pubmed.ncbi.nlm.nih.gov/42509033/
pubmed.ncbi.nlm.nih.gov
Acute palliative care unit discharge outcomes: intensive versus non-intensive care transfers - PubMed
Despite the APCU mortality in this cohort being high, 22.4% of patients transferring from the ICU were successfully discharged to the community. HFNC use at the time of APCU transfer was independently associated with increased odds of APCU mortality.
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Eduardo Bruera @brueraeduardo.bsky.social · 04/09/2026
pubmed.ncbi.nlm.nih.gov/42516881/
pubmed.ncbi.nlm.nih.gov
Person-Centered Care Planning: Palliative Symptom Management in Multiple Chronic Conditions - PubMed
Shift palliative skills upstream in primary care; adopt standardized tools; and measure quality outcomes.
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Eduardo Bruera @brueraeduardo.bsky.social · 04/09/2026
pubmed.ncbi.nlm.nih.gov/41793478/
pubmed.ncbi.nlm.nih.gov
A scoping review of breakthrough cancer pain: mapping the evidence landscape - PubMed
This scoping review maps heterogeneous evidence characterized by inconsistent definitions, selected populations, short-term outcomes, and geographic concentration. Key knowledge gaps include: standardized operational definitions, patient-centered functional outcomes, long-term efficacy and safety da …
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Eduardo Bruera @brueraeduardo.bsky.social · 04/09/2026
pubmed.ncbi.nlm.nih.gov/42019829/
pubmed.ncbi.nlm.nih.gov
What Do Medical Oncologists Want for Themselves at The End-of-Life? Analysis of Go Wish Cards Game - PubMed
The use of the GWCG promoted reflection on participants' own EoL values and priorities, facilitating dialogue on sensitive topics. This self-reflective process can enhance participants' sensitivity to understanding what is essential to patients. Thus, the GWCG may contribute to more humanized, refle …
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Eduardo Bruera @brueraeduardo.bsky.social · 03/09/2026
@slightlycaustic.bsky.social
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Eduardo Bruera @brueraeduardo.bsky.social · 01/09/2026
This paper examines the implications of AI for patients, physicians, and health care and provides guidance for its ethical use. pubmed.ncbi.nlm.nih.gov/42673596/
pubmed.ncbi.nlm.nih.gov
Ethics and Professionalism in Artificial Intelligence and Medical Practice: A Position Paper From the American College of Physicians - PubMed
Artificial intelligence (AI) in health care is being rapidly adopted in perhaps one of the most rapid implementations of technology in medicine to date. Better thought of as augmented intelligence, as a tool that provides assistance to physicians and patients, many guidelines for its use have been i …
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Eduardo Bruera @brueraeduardo.bsky.social · 31/08/2026
The delivery of optimal supportive care involves a family-focused perspective such as screening for parenting status and referrals to social work services to address the need of tangible resources and manage parenting-related distress. pubmed.ncbi.nlm.nih.gov/37148983/
pubmed.ncbi.nlm.nih.gov
Living With an Advanced Cancer While Parenting Minor Children: A Needs Assessment Study - PubMed
The delivery of optimal supportive care involves a family-focused perspective such as screening for parenting status and referrals to social work services to address the need of tangible resources and manage parenting-related distress.
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Eduardo Bruera @brueraeduardo.bsky.social · 31/08/2026
Ciprofloxacin can inhibit CYP3A4 enzymes, reducing fentanyl metabolism. Combining them can elevate fentanyl levels, significantly increasing the risk of severe toxicity and respiratory depression. pubmed.ncbi.nlm.nih.gov/37150364/
pubmed.ncbi.nlm.nih.gov
Fentanyl Toxicity Related to Concomitant Use of Ciprofloxacin and its Effects as a CYP3A4 Inhibitor - PubMed
Fentanyl Toxicity Related to Concomitant Use of Ciprofloxacin and its Effects as a CYP3A4 Inhibitor
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Eduardo Bruera @brueraeduardo.bsky.social · 29/08/2026
PubMed is not updated due apparently to massive federal government layoffs and it is now unreliable . We need a European/ Canadian non corporate COI alternative source of quality peer reviewed medical information.
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Eduardo Bruera @brueraeduardo.bsky.social · 21/08/2026
pubmed.ncbi.nlm.nih.gov/30192372/
pubmed.ncbi.nlm.nih.gov
Predicting the risk for aberrant opioid use behavior in patients receiving outpatient supportive care consultation at a comprehensive cancer center - PubMed
The current results indicate a high frequency of an elevated risk of ADB among patients with cancer. Men and patients who have anxiety, financial distress, and a prior history of alcoholism/illicit drug use are at increased risk of ADB.
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Eduardo Bruera @brueraeduardo.bsky.social · 21/08/2026
pubmed.ncbi.nlm.nih.gov/30200370/
pubmed.ncbi.nlm.nih.gov
Delivering Pediatric Palliative Care: From Denial, Palliphobia, Pallilalia to Palliactive - PubMed
Among the over 21 million children with life-limiting conditions worldwide that would benefit annually from a pediatric palliative care (PPC) approach, more than eight million would need specialized PPC services. In the United States alone, more than 42,000 children die every year, half of them infa …
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Eduardo Bruera @brueraeduardo.bsky.social · 21/08/2026
Oral breakthrough opioid 10% of daily dose works quite well. Rapid fentanyl unnecessary and dangerous pubmed.ncbi.nlm.nih.gov/30254187/
pubmed.ncbi.nlm.nih.gov
Response to Oral Immediate-Release Opioids for Breakthrough Pain in Patients with Advanced Cancer with Adequately Controlled Background Pain - PubMed
Oral immediate-release opioids are standard treatment for cancer breakthrough pain. However, information regarding treatment response to these commonly used opioids is limited. This study provides information that the vast majority of patients with advanced cancer, with adequately controlled backgro …
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Eduardo Bruera @brueraeduardo.bsky.social · 18/08/2026
www.facebook.com/share/p/1EMh...
facebook.com
Facebook
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Eduardo Bruera @brueraeduardo.bsky.social · 14/08/2026
Most advanced cancer pts have low vitamin D .ncbi.nlm.nih.gov/42104875/ pubmed.ncbi.nlm.nih.gov/21964001/
pubmed.ncbi.nlm.nih.gov
Hypovitaminosis D in acute inpatient cancer rehabilitation: Prevalence, predictors, and practical implications - PubMed
Hypovitaminosis D was highly prevalent among adult patients with cancer undergoing inpatient rehabilitation. Identified predictors, including relatively younger age and neurogenic bladder or bowel, may help guide targeted screening.
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Eduardo Bruera @brueraeduardo.bsky.social · 14/08/2026
The Opiophobic epidemic is causing severe unnecessary suffering to thousands of patients with pain due to advanced cancer and their families. Politicians and executives are not leading. pubmed.ncbi.nlm.nih.gov/42543383/
pubmed.ncbi.nlm.nih.gov
Managing Pain in Patients Receiving Palliative Cancer Care During the Opiophobia Epidemic - PubMed
Managing Pain in Patients Receiving Palliative Cancer Care During the Opiophobia Epidemic
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Eduardo Bruera @brueraeduardo.bsky.social · 13/08/2026
Earlier outpatient referral and closer neurology-palliative care collaboration may enable longitudinal GOC conversations, anticipate complex decisions, and reduce the clinical, emotional, and ethical burden of advanced disease. pubmed.ncbi.nlm.nih.gov/42578627/
pubmed.ncbi.nlm.nih.gov
Missed Opportunities for Goals-of-Care Conversations in a Patient With End-Stage Juvenile Huntington's Disease: A Case Report - PubMed
IntroductionJuvenile Huntington's disease (JHD) is a rare, severe neurodegenerative disorder with early onset, high symptom burden, and a predictable trajectory toward advanced disability and premature death. Despite this, goals-of-care (GOC) conversations and advance care planning are often delayed …
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Eduardo Bruera @brueraeduardo.bsky.social · 11/08/2026
Educational interventions, increased awareness of local regulations, and standardized preprinted information for patients may improve counseling and promote safer opioid prescribing practices pubmed.ncbi.nlm.nih.gov/42576464/
pubmed.ncbi.nlm.nih.gov
Palliative care specialists infrequently discuss driving safety with their patients with cancer when prescribing opioids - PubMed
Opioids may impair the ability to drive especially when prescribed for the first time or when the dose is increased. Because driving is closely associated with independence and quality of life, discus...
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Eduardo Bruera @brueraeduardo.bsky.social · 08/08/2026
www.linkedin.com/posts/ignaci...
linkedin.com
JPM article | Ignacio Borque
Thrilled to see our work published! A modified #Delphistudy defining #qualityindicators for postgraduate palliative care programs. Endlessly grateful to every co-author for their dedication — this ...
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Eduardo Bruera @brueraeduardo.bsky.social · 07/08/2026
A consensus-based set of 21 quality indicators for postgraduate academic programs in palliative care was developed, providing a structured framework for evaluation pubmed.ncbi.nlm.nih.gov/42563144/
pubmed.ncbi.nlm.nih.gov
Developing Quality Indicators for Postgraduate Academic Programs in Palliative Care: A Modified Delphi Consensus Study - PubMed
A consensus-based set of 21 quality indicators for postgraduate academic programs in palliative care was developed, providing a structured framework for evaluation. The findings highlight a key challe...
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Eduardo Bruera @brueraeduardo.bsky.social · 06/08/2026
www.linkedin.com/posts/lisa-p...
linkedin.com
Managing Pain in Patients Receiving Palliative Cancer Care During the Opiophobia Epidemic - Eduardo Bruera, Joseph A. Arthur, 2026 | Lisa Pelzek-Braun
Journal of Palliative Medicine: Notes from the Editor
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Eduardo Bruera @brueraeduardo.bsky.social · 03/08/2026
Palliative care involvement was associated with an increase in symptom control medications and decrease in medications for comorbid conditions over time. pubmed.ncbi.nlm.nih.gov/25123192/
pubmed.ncbi.nlm.nih.gov
Changes in medication profile among patients with advanced cancer admitted to an acute palliative care unit - PubMed
Palliative care involvement was associated with an increase in symptom control medications and decrease in medications for comorbid conditions over time.
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Eduardo Bruera @brueraeduardo.bsky.social · 03/08/2026
Only 25% of ED visits by patients with advanced cancer receiving palliative care were potentially avoidable. Proactive efforts to improve communication and support between scheduled appointments are needed. pubmed.ncbi.nlm.nih.gov/25131891/
pubmed.ncbi.nlm.nih.gov
Avoidable and unavoidable visits to the emergency department among patients with advanced cancer receiving outpatient palliative care - PubMed
Nearly one-fourth of ED visits by patients with advanced cancer receiving palliative care were potentially avoidable. Proactive efforts to improve communication and support between scheduled appointme...
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Eduardo Bruera @brueraeduardo.bsky.social · 03/08/2026
Body image dissatisfaction was frequent and associated with symptom burden. A single item ≤3 has a sensitivity of 70% for body image satisfaction screening pubmed.ncbi.nlm.nih.gov/25188590/
pubmed.ncbi.nlm.nih.gov
Screening for body image dissatisfaction in patients with advanced cancer: a pilot study - PubMed
Body image dissatisfaction was frequent and associated with symptom burden. A single item ≤3 has a sensitivity of 70% for body image satisfaction screening.
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Eduardo Bruera @brueraeduardo.bsky.social · 03/08/2026
Opiophobic cocktails are less effective , addictive , and make opioid initiation and titration much harder pubmed.ncbi.nlm.nih.gov/42543383/
pubmed.ncbi.nlm.nih.gov
Managing Pain in Patients Receiving Palliative Cancer Care During the Opiophobia Epidemic - PubMed
Managing Pain in Patients Receiving Palliative Cancer Care During the Opiophobia Epidemic
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Eduardo Bruera @brueraeduardo.bsky.social · 02/08/2026
ECOG PS assessments by PC specialists and nurses were significantly higher than those of medical oncologists. Systematic efforts to increase regular interdisciplinary communications may help to bridge this gap. pubmed.ncbi.nlm.nih.gov/25542550/
pubmed.ncbi.nlm.nih.gov
Differences in Performance Status Assessment Among Palliative Care Specialists, Nurses, and Medical Oncologists - PubMed
ECOG PS assessments by PC specialists and nurses were significantly higher than those of medical oncologists. Systematic efforts to increase regular interdisciplinary communications may help to bridge...
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Eduardo Bruera @brueraeduardo.bsky.social · 02/08/2026
Sixty-one percent of patients with a diagnosis of delirium by a palliative care specialist were missed by the primary referring team. Patients with MD were frequently referred for pain. Universal screening of cancer patients for delirium is recommended. pubmed.ncbi.nlm.nih.gov/25617070/
pubmed.ncbi.nlm.nih.gov
The frequency of missed delirium in patients referred to palliative care in a comprehensive cancer center - PubMed
Sixty-one percent of patients with a diagnosis of delirium by a palliative care specialist were missed by the primary referring team. Patients with MD were frequently referred for pain. Universal scre...
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Eduardo Bruera @brueraeduardo.bsky.social · 28/07/2026
Despite the PCU mortality in this cohort being high, 22.4% of patients transferring from the ICU were successfully discharged to the community. High flow O2 at the time of PCU transfer was independently associated with increased mortality pubmed.ncbi.nlm.nih.gov/42509033/
pubmed.ncbi.nlm.nih.gov
Acute palliative care unit discharge outcomes: intensive versus non-intensive care transfers - PubMed
Despite the APCU mortality in this cohort being high, 22.4% of patients transferring from the ICU were successfully discharged to the community. HFNC use at the time of APCU transfer was independently...
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Eduardo Bruera @brueraeduardo.bsky.social · 28/07/2026
Shift palliative skills upstream ; adopt standardized tools; and measure quality outcomes. pubmed.ncbi.nlm.nih.gov/42516881/
pubmed.ncbi.nlm.nih.gov
Person-Centered Care Planning: Palliative Symptom Management in Multiple Chronic Conditions - PubMed
Shift palliative skills upstream in primary care; adopt standardized tools; and measure quality outcomes.
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Eduardo Bruera @brueraeduardo.bsky.social · 26/07/2026
Despite intensive management some cancer patients continue to experience high symptom burden as they approached death. It is unethical for a hospital with an intensive care unit to have no palliative care unit. pubmed.ncbi.nlm.nih.gov/25242021/
pubmed.ncbi.nlm.nih.gov
Symptom Expression in the Last Seven Days of Life Among Cancer Patients Admitted to Acute Palliative Care Units - PubMed
Despite intensive management in APCUs, some cancer patients continue to experience high symptom burden as they approached death.
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Eduardo Bruera @brueraeduardo.bsky.social · 26/07/2026
pubmed.ncbi.nlm.nih.gov/25242021/
pubmed.ncbi.nlm.nih.gov
Symptom Expression in the Last Seven Days of Life Among Cancer Patients Admitted to Acute Palliative Care Units - PubMed
Despite intensive management in APCUs, some cancer patients continue to experience high symptom burden as they approached death.
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Eduardo Bruera @brueraeduardo.bsky.social · 26/07/2026
When not possible as the primary opioid methadone can be very effective in small doses as a adjuvant pubmed.ncbi.nlm.nih.gov/25369859/
pubmed.ncbi.nlm.nih.gov
Dual opioid therapy using methadone as a coanalgesic - PubMed
Dual opioid therapy using methadone as a coanalgesic
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Eduardo Bruera @brueraeduardo.bsky.social · 26/07/2026
We need to expect unexpected deaths even in palliative care units pubmed.ncbi.nlm.nih.gov/25499421/
pubmed.ncbi.nlm.nih.gov
Frequency and factors associated with unexpected death in an acute palliative care unit: expect the unexpected - PubMed
Unexpected death occurred in an unexpectedly high proportion of patients in the APCU setting and was associated with fewer signs of impending death. Our findings highlight the need for palliative care...
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