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Bright Giant @brightgiant.bsky.social · 18/12/2025

Homologous series of previously overlooked polymerization byproducts (H-PFCAs) detected near fluoropolymer production plant using #SIRIUS6. #SIRIUSDiscoveries #PFAS #Fluoropolymers 💡 Blog post: buff.ly/P9grMJQ (3 min) 📄 Publication: buff.ly/a960M9n

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Bright Giant @brightgiant.bsky.social · 16/12/2025

Using #SIRIUS6, researchers found the #Biopesticide 6-PP to be produced via the polyketide biosynthesis pathway in Trichoderma fungi. This finding may pave the way for developing improved biocontrol agent. #SustainableAgriculture 💡 SIRIUS discoveries: buff.ly/HP0dTWO 📄 Publication: buff.ly/J5JE4Tk

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Bright Giant @brightgiant.bsky.social · 11/12/2025

Metabolic adaptations of a salt-tolerant willow are specific to the plant organ and the salt anion. The researchers used #SIRIUS6 to identify the chemical structures of unknown compounds from mass spectrometry data. 💡 SIRIUS discoveries: buff.ly/HP0dTWO 📄 Publication: buff.ly/plLgOGE

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Bright Giant @brightgiant.bsky.social · 09/12/2025

#NonTargetedAnalysis #ChemicalClassification with #SIRIUS6 identifies cell surface glycans & membrane lipids as influential drivers of adaptation to heat stress in rice coral hosting thermosensitive and thermotolerant symbionts. 💡 SIRIUS discoveries: buff.ly/HP0dTWO 📄 Publication: buff.ly/KeqUClP

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Bright Giant @brightgiant.bsky.social · 04/12/2025

Unlocking the secrets of healing mushrooms 🍄 #SIRIUS6 was instrumental in detailing the metabolic basis for the production of sesquiterpenoids in the #MedicinalMushrooms Sanghuangporus. #SIRIUSDiscoveries #NaturalProducts 💡 More SIRIUS discoveries: buff.ly/HP0dTWO 📄 Publication: buff.ly/RDAMNtB

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Bright Giant @brightgiant.bsky.social · 02/12/2025

Hidden Players in Drug Efficacy: Using #SIRIUS6, researchers decoded the crucial role of the gut microbiome in altering the chemical structure and efficacy of GPCR drugs. 💡 Blog post: buff.ly/WtrJf2m (5 min) 📄 Publication: buff.ly/8o1ekPv #SIRIUSDiscoveries #DrugMetabolism #PersonalizedMedicine

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Bright Giant @brightgiant.bsky.social · 27/11/2025

Based on this tutorial our software #SIRIUS6 plays a significant role in prioritization strategies for #NonTargetScreening in environmental samples by generating molecular fingerprints which are used for compound identification or toxicity prediction. 📄 Read the tutorial: buff.ly/M9gNmBR

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Bright Giant @brightgiant.bsky.social · 25/11/2025

🌱 The quest to enhance long-term soil carbon storage 🌏 #SIRIUS6 #CompoundClassPrediction was essential for annotating 80% of the previously unknown metabolite features of tall wheatgrass root exudates. 💡 More #SIRIUSDiscoveries: buff.ly/HP0dTWO 📄 Publication: buff.ly/sYB1nPm

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Bright Giant @brightgiant.bsky.social · 20/11/2025

How can we assess the risk of a compound we can't even name? SIRIUS molecular fingerprints serve as crucial inputs for predictive models, such as #ToxicityPrediction, even when the exact identity of a compound is unknown. 📄 doi.org/10.1016/j.en... #SIRIUSFacts #SIRIUS6 #NonTargetAnalysis

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Bright Giant @brightgiant.bsky.social · 13/11/2025

#SIRIUS6 in a #NonTargetedAnalysis to identify unknown chemical compounds with potential estrogenic activity to investigate the link between #DrinkingWater #contaminants and #BreastCancer incidence. ▶️ Try SIRIUS now: buff.ly/K8wQ3ER 💡 Original publication: buff.ly/SZ2LPbp #SmallMoleculeID

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Bright Giant @brightgiant.bsky.social · 11/11/2025

Untargeted #metabolomics using #SIRIUS6 is mapping the #InternationalSpaceStation Most extensive look yet at the microbial and chemical landscape of the ISS. 💡 Blog post: buff.ly/nGt934u (5 min) 📄 Original publication: buff.ly/s8BBclb ▶️ Try #SIRIUS6 now: buff.ly/K8wQ3ER #SIRIUSDiscoveries

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Bright Giant @brightgiant.bsky.social · 06/11/2025

#SIRIUS6 compound class prediction helps to validate ethanol extraction for human faecal #metabolomics as a valid, safer, and more economical alternative to the common methanol extraction. ▶️ Try SIRIUS now: buff.ly/x7dNWAR 📄 Publication: buff.ly/cGkUOyi #SIRIUSDiscoveries #Microbiome

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Bright Giant @brightgiant.bsky.social · 04/11/2025

New study from the long-running @jena-experiment.bsky.social challenges core ecological assumption: that in a diverse ecosystem, plants can save energy on defenses and focus on growth. 📄 Blog feature: buff.ly/LgCEGpL 📄 Publication: buff.ly/u6lzwUe #SIRIUS6 #SIRIUSDiscoveries #NonTargetedAnalysis

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Bright Giant @brightgiant.bsky.social · 30/10/2025

#MultiOmics study revelead link between microbial community structure and chemical profile of the surface #metabolome in Saccharina latissima. 💡 Check out more SIRIUS discoveries: buff.ly/aI5m3ps 📄 Paper: buff.ly/uUT34E0 #SIRIUSDiscoveries #MarineBiology #Microbiology #ChemicalEcology

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Bright Giant @brightgiant.bsky.social · 28/10/2025

Green solvents can effectively extract diverse bioactive compounds from Melissa officinalis leaves. SIRIUS was employed for the comprehensive annotation of metabolites, resulting in the putative annotation of 444 metabolites. 💡 More #SIRIUSDiscoveries: buff.ly/aI5m3ps 📄 Paper: buff.ly/AEpoIFv

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Bright Giant @brightgiant.bsky.social · 22/10/2025

In this #NonTargetedAnalysis utilizing SIRIUS, researcher successfully identify common and previously unreported chemical contaminants in human milk, including novel parabens. Blog post: buff.ly/0vQizvG Paper: buff.ly/Mg8axQF #SIRIUS6 #StructureElucidation

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Bright Giant @brightgiant.bsky.social · 15/10/2025

Using SIRIUS, researcher identified anti-viral compounds in Caesalpinia mimosoides hydroethanolic extract that help to inhibit influenza A virus by targeting two critical viral proteins. ▶️ Try SIRIUS: buff.ly/x7dNWAR 💡 More SIRIUS discoveries: buff.ly/aI5m3ps 📄 Original publication: buff.ly/qR8zEvb

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Bright Giant @brightgiant.bsky.social · 08/10/2025

New review on #MassSpectrometry-based #Metabolomics for #NaturalProductResearch positions #SIRIUS6 as the leading suite for molecular structure annotation. ▶️ Try SIRIUS now: buff.ly/x7dNWAR 📄 Read the full review: buff.ly/0mMyixO #StructureElucidation #SmallMoleculeID #MachineLearning

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Bright Giant @brightgiant.bsky.social · 01/10/2025

MCheM integrates online chemical labeling reactions directly into the LC-MS/MS workflow to provide structural information which is fed into #SIRIUS6 via @mzmine.bsky.social to significantly constrain the molecular structure search space and boost annotation accuracy. Learn more: buff.ly/iib0L6I

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Bright Giant @brightgiant.bsky.social · 24/09/2025

🧠 ✏️ Your chemical intuition, now integrated into #SIRIUS6. Have you tried the new Structure Sketcher yet? ▶️ Watch our new YouTube tutorial to learn how to use the Structure Sketcher and elevate your annotation process: www.youtube.com/watch?v=_byB... #HowToSIRIUS #SmallMoleculeID #MassSpec

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Bright Giant @brightgiant.bsky.social · 10/09/2025

Do you ever look at the best hit from a structure database search and instantly know how to improve it? In #SIRIUS6, your chemical intuition just got a powerful new tool: the Structure Sketcher. buff.ly/c4cfGvW #HowToSIRIUS #SmallMoleculeID

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Bright Giant @brightgiant.bsky.social · 03/09/2025

🌍✨We're blown away by the growth of the SIRIUS community! We're seeing unprecedented usage and impact of our software across the globe. ⬆️ 1.000.000.000+ processed queries 👥 1.500+ monthly active users 🙏 Thank you for being part of this journey. We're excited to see what you discover next!

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Bright Giant @brightgiant.bsky.social · 27/08/2025

⚠️ Important Announcement for SIRIUS 5 Users! ⚠️ Maintenance and support for SIRIUS 5 will officially end on 🗓️ February 28, 2026. To ensure you continue to benefit from the latest advancements, we highly recommend upgrading to #SIRIUS6: buff.ly/91GQKjH #SIRIUSSoftware #SmallMoleculeAnnotation

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Bright Giant @brightgiant.bsky.social · 20/08/2025

🚀 SIRIUS v6.3 is here! We're excited to introduce the latest version of #SIRIUS with powerful new features to enhance small molecule identification. ⬇️ Learn more and download SIRIUS v6.3 today: bright-giant.com/sirius-relea... #SIRIUS6 #MSsoftware #MassSpectrometry #SmallMoleculeIdentID

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Bright Giant @brightgiant.bsky.social · 18/08/2025

Test your #SIRIUS6 knowledge! 🧠 ❓ The SIRIUS software uses an ILP solver to perform which specific task ❓ Drop a comment with your answer! The correct answer will be revealed on Friday. Learn more about #SIRIUSSoftware: buff.ly/vBOiq3F #SmallMoleculeID #StructureElucidation

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Bright Giant @brightgiant.bsky.social · 14/08/2025

Times Are Changing, but Order Matters: The @boeckerlab.bsky.social has introduced a groundbreaking two-step method for transferable retention time prediction buff.ly/vcFreLJ #Chromatography #RetentionTime #MachineLearning #SmallMoleculeIdentification

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Bright Giant @brightgiant.bsky.social · 30/07/2025

SIRIUS identifies potentially allergenic transformation products of tattoo pigments in new online-LC-EC-MS approach that overcomes the challenge of impure pigment standards by separating pigments from impurities before simulating their metabolism. #SmallMoleculeID #SIRIUS6 doi.org/10.1007/s002...

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Bright Giant @brightgiant.bsky.social · 23/07/2025

🚨 Detecting deadly nitazenes just got easier. A new study uses untargeted LC-HRMS + #SIRIUS6 to ID key phase I/II metabolites, boosting opioid detection. Advanced #MSsoftware + #MachineLearning are shaping the future of #Toxicology. #DrugDiscovery #SIRIUSDiscoveries doi.org/10.3390/meta...

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Bright Giant @brightgiant.bsky.social · 17/07/2025

🪸 New study reveals coral resilience may be inherited! Using LC-MS/MS + #SIRIUS, scientists found thermal tolerance compounds passed from parent to offspring in Montipora capitata. Biochemical “memory” could guide reef restoration in a warming world. 🪸 #CoralReef #Science doi.org/10.1038/s414...

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Bright Giant @brightgiant.bsky.social · 14/07/2025

The number of potential small molecules in #ChemicalSpace corresponds to the number of atoms in the observable universe. 🤯 But the real challenge isn’t just the scale — it’s the complexity. Molecules are graphs, not strings, making it impractical, if not impossible, to simply enumerate them all.

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Bright Giant @brightgiant.bsky.social · 25/06/2025

🚀 Great turnout at our #SIRIUS6 workshop at #MetSoc2025. 80+ attendees & a lively Q&A! We showcased how SIRIUS goes beyond spectral libraries with structure generation & analog search. Missed it? Let’s connect at booth T11. #MassSpectrometry #Metabolomics #AutomatedAnnotation

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Bright Giant @brightgiant.bsky.social · 24/06/2025

More first-hand insights from the #SIRIUSCommunity on the third day of #MetSoc2025. Don't miss the opportunity to get in touch! #SIRIUS6 #MetaboliteAnnotation #SmallMoleculeID #MassSpectrometry #SIRIUSEvents

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Bright Giant @brightgiant.bsky.social · 24/06/2025

Novel transformation product annotation with #SIRIUS6 - Don't miss this talk at #MetSoc2025 ! 🎤 @mfleischauer.bsky.social‬ 📅 June 25 | 4:30 p.m. – 4:50 p.m. 📍 Congress Hall | Abstract #471 #Metabolomics #LCMSMS #SmallMoleculeID #TransformationProducts #MassSpectrometry #StructureAnnotation

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Bright Giant @brightgiant.bsky.social · 24/06/2025

🗓️ Plan your Tuesday: Gain first-hand 👌 SIRIUS insights at #MetSoc2025 Make sure to mark your calendars for these talks and posters from the #SIRIUSCommunity #SIRIUS6 #MetaboliteAnnotation #SmallMoleculeID #MassSpectrometry #SIRIUSEvents

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Bright Giant @brightgiant.bsky.social · 23/06/2025

We are beyond happy to see so many contributions from the #SIRIUScommunity at tat #Metabolomics2025. Don't miss the opportunity to get in touch and gain first-hand insights how you can integrate SIRIUS into your annotation workflow.

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Bright Giant @brightgiant.bsky.social · 23/06/2025

We’re thrilled to share our SIRIUS contributions at #Metabolomics2025 in Prague! 🇨🇿 We can’t wait to engage with the #metabolomics community, share our expertise, and showcase how #SIRIUS6 is empowering more confident, comprehensive analyses. #MetaboliteAnnotation #MassSpectrometry

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Bright Giant @brightgiant.bsky.social · 11/06/2025

We are excited to announce our new Short Course Tutorial Series on YouTube that will guide you through the essential features of #SIRIUS6 to help you get the most out of your data. Watch the full playlist here: bright-giant.com/short-course... and don't forget to subscribe! #HowToSIRIUS

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Bright Giant @brightgiant.bsky.social · 21/05/2025

Get ready for #ASMS2025! We've prepared some SIRIUS merch for you and would be happy to see many of you showing your support. 🩷 💙 Come find us at our booth 208 and say hello to our team. 👋 We can't wait to connect. #SIRIUSEvents #SIRIUSSoftware #MassSpectrometry #MachineLearning

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Bright Giant @brightgiant.bsky.social · 20/05/2025

We're presenting a poster at #ASMS2025! 🥳 Learn how SIRIUS annotates #TransformationProducts, validated with spectral library analog search. 🗣️ Kai Dührkop 📅 Tue, Jun 03 #️⃣ TP 475 Come by to learn how #SIRIUSSoftware can accelerate your research! ⏩ #MassSpectrometry #SmallMoleculeIdentification

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Bright Giant @brightgiant.bsky.social · 14/05/2025

Join the SIRIUS community 🌐👥 #SIRIUS has evolved into an all-in-one solution for #SmallMoleculeIdentification trusted by scientists worldwide & processing millions of queries every year. 🙌 Thanks to everyone who's helped build, shape, and support SIRIUS. ▶️ Get started right away: bright-giant.com

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Bright Giant @brightgiant.bsky.social · 12/05/2025

Experience SIRIUS in use at #ASMS2025 🚀 We’re excited to see how researchers and partners are showcasing SIRIUS for small molecule annotation, even in the most complex analytical workflows. 💡 Don’t miss the chance to gain first-hand insights. #SIRIUSEvents #MassSpectrometry #SIRIUSUsers

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Bright Giant @brightgiant.bsky.social · 07/05/2025

☕ Bright Giant at Agilent Breakfast Session ☕ Join us Tues, June 3 to learn about analysing xenobiotic biotransformations with Explorer and SIRIUS. 📍 Room 341/342 | ⏰ 7–8:15 AM 🎤 Mark Sartain & Martin Andre Hoffmann 🔗 web.cvent.com/event/17080f... #SIRIUSEvents #ASMS2025 #MassSpectrometry

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Bright Giant @brightgiant.bsky.social · 05/05/2025

🚨 Join us at #ASMS2025! 🚨 Catch us at Booth 208 to see SIRIUS in action — our all-in-one software for #AI -driven #StructureElucidation of #SmallMolecules. Let’s connect, talk science, and push the boundaries of small molecule analysis. More updates soon 👀 #SIRIUSEvents #MassSpectrometry

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Bright Giant @brightgiant.bsky.social · 30/04/2025

Learn #HowToSIRIUS with our new tutorials. 💡 First tutorial: Screen for hidden transformation products. 💡 Generate a custom transformation products database to identify and validate precursor compounds and transformation products. ✅ 🔗 bright-giant.com/2025/04/28/h... #MassSpec #NonTargeted

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Bright Giant @brightgiant.bsky.social · 28/04/2025

Pharmaceuticals in wastewater break down into potentially even more toxic and persistent products—and we’re missing them. With SIRIUS, we found 80 drugs and 292 transformation products, many invisible to traditional methods. 🔗 bright-giant.com/2025/04/28/p... #MassSpec #EcoTox #WaterQuality

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Bright Giant @brightgiant.bsky.social · 21/03/2025

🗣🗯️ The #DarkMetabolome Debate: Are unknown signals just measurement artefacts? ‼️ #MassSpectrometry does produce different ion forms but claiming the metabolome is mostly known is misleading ‼️ 📄 Read the original publication: doi.org/10.1038/s422... #UntargetedMetabolomics ⬇️ Read more below ⬇️

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Bright Giant @brightgiant.bsky.social · 17/02/2025

Move beyond compound identification and focus on broader chemical patterns instead. Get a nuanced understanding of the #ChemicalComposition of a complex #untargetedMS sample without the necessity for exhaustive compound annotation. 📄 bright-giant.com/2025/02/13/m... #SIRIUSDiscoveries #SIRIUS_MS

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Bright Giant @brightgiant.bsky.social · 03/02/2025

We’re proud to announce that we are a ✨START-UP SPONSOR for #Metabolomics2025✨, the 21st Annual International Conference of the Metabolomics Society, taking place June 22-26, 2025, in Prague, Czech Republic! 🇨🇿 www.metabolomics2025.org #SIRIUSEvents #Metabolomics #MassSpectrometry #MSSoftware

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