Explore BrainCase PRV Tracers for peripheral neural circuit tracing. Discover retrograde transsynaptic mapping across multiple organs with validated research applications.

Comprehensive guide to ssAAV vs scAAV, including Definitions、 Applications(Gene Editing, miRNA Overexpression, Target Gene Overexpression) and Selection Recommendations.

Brain Case showcased its brain–computer interface (BCI) neurotechnology platform, AAV viral vector tools, neural interface evaluation system, and preclinical neuroscience CRO services at the 12th Chin...

The α-Syn-6H-EGFP/tdT sensor provides a comprehensive solution for α-synucleinopathy research, covering aggregate labeling, in vivo tracking, and drug screening.

Tool viruses (viral vectors) are engineered biological delivery systems widely used in gene therapy, cell therapy, neuroscience, and vaccine development. This article covers Viral structure and applic...

Discover key retrograde AAV tools for neural tracing, gene delivery and neurological research. Detailed introduction to AAV11, AAV9-Retro and more.

Explore commonly used cardiac targeting strategies, including AAV serotype selection, cardiac-specific promoters, and neurotropic viral tracers for heart gene delivery and cardiac neural circuit resea...

PinkyCaMP, an mScarlet-based red GECI, offers high brightness, photostability, and multicolor compatibility for in vitro, ex vivo, and in vivo neural imaging.

Join the Brain Case Membership Program. Enjoy better pricing on in-stock AAVs, custom packaging discounts, priority scheduling, and expert consultations.

Much progress has been made in understanding astrocytes, but details on their functions and interactions remain difficult to determine. Yu, Nagai and Khakh give an overview of recent advances in the t...

Plasmids are fundamental tools in molecular biology, used for gene cloning, protein expression, genome editing, and synthetic virus construction......

Launched an innovative research service—“Neural Circuit Tracing + Targeted Spatial Omics + Neuronal Classification Analysis”

Explore the key differences between TH-Cre and DBH-Cre mice, including their expression profiles, construction methods, and suitable research applications for studying dopaminergic and noradrenergic s...

The α-Syn-6H-EGFP/tdT sensor provides a comprehensive solution for α-synucleinopathy research, covering aggregate labeling, in vivo tracking, and drug screening.

Learn everything about RNA interference (RNAi), from vector design to sequence selection, and how to optimize siRNA efficiency for gene silencing.

Explore excitatory and inhibitory optogenetic proteins, their features, and optimal excitation wavelengths for precise neural control and research applications.

Celebrate Easter 2026 with exclusive discounts on in-stock AAV vectors and custom packaging services from Brain Case Biotech. Enjoy up to 20% off. Limited-time offer!

Improved red and green indicators for norepinephrine and their characterization are reported. These indicators allow detection of norepinephrine release in awake behaving mice in dual-color fiber phot...

HSV virus injection into L5 DRG neurons in mice, enhanced by bortezomib immunosuppressant, significantly increases neuronal infection and gene marker expression.

AAVLINK enables efficient delivery of large genes for genetic diseases and CRISPR tools, overcoming challenges in gene splitting and neuron-specific expression.

Master the core techniques for successful lentivirus in vitro infection. This comprehensive guide covers protocols, MOI optimization, troubleshooting, and key precautions.

Discover Brain Case Biotech's viral vectors with mBaoJin and mScarlet3-H proteins, offering superior photostability and precise delivery for advanced imaging in cell biology and neuroscience.

Explore key tips and guidelines for using the RV retrograde trans-synaptic labeling system in neural circuit research. Learn about optimal virus doses, injection protocols, and best practices.

This study demonstrates that BF839 exerts its antiepileptic effects through the colon ChAT+ cell-vagus nerve ganglion-NTS cholinergic pathway.

In the triple-negative breast cancer ecosystem, sensory neurons activate cancer-associated fibroblasts to secrete collagen, thus stimulating a dense extracellular matrix that drives immune exclusion.

Fudan University’s latest research uncovers a crucial neural circuit (PC → Lent → DG) responsible for driving epileptic seizures and brain-wide functional reorganization.

chemogenetics, NELC neurons, rMR pathway, liver regeneration, Th-Cre mice, AAV vectors, CNO administration, neural regulation, chronic stress, liver recovery, proliferation markers, Ki67, PCNA, liver ...

Learn about the AAV-BR1, AAV-BI30, AAV-X1 series, and rAAV-miniBEND systems for gene delivery, editing, and precise disease modeling in neurovascular research. These cutting-edge tools are paving the ...

This study identifies a non-spinal bladder–brain vagal pathway that transmits inflammatory signals and maintains bladder homeostasis, revealed by viral tracing , DREADD-fMRI and Immunohistochemistry.

A comprehensive comparison of AAV and lentiviral vectors, covering gene delivery mechanisms, packaging capacity, immunogenicity, and in vivo vs in vitro applications, with case studies from gene thera...