The functional role of peripheral GIPR action in weight loss is yet to be fully defined in a preclinical setting. Here, Yu et al. propose a mechanism whereby inducible activation of GIPR in adipocytes promotes energy wasting through futile calcium cycling, triggering profound weight loss in the obese state.

BACKGROUND: The prevalence of secondary causes of hypertension in young adults is unknown, and therefore, there is no consensus about the indication of screening of secondary hypertension (2HTN) in th...