Dopamine suppresses GABA release from striatal terminals in the substantia nigra pars reticulata. Molinari et al. recently demonstrated that this suppression is frequency-dependent—instituting a high-...

A monoaminergic high-pass filter regulates basal ganglia output activity.

Mothers can fiercely defend their young, but how the brain triggers this response remains to a large extent a mystery. Here, authors show that a dormant, hormone-sensitive brain circuit switches on to spark maternal aggression during the lactation period.

Vill du bidra till medicinsk forskning av toppkvalitet? Det strategiska forskningsprogrammet för diabetes (SRP Diabetes) vid Karolinska Institutet finansierar ett prestigefyllt stipendieprogram för

Do you want to contribute to top quality medical research? Join our dynamic and collaborative research team in Anders Borgkvist’s laboratory at the Department of Neuroscience, Karolinska Institute,

An imbalance between the direct and indirect pathways of the striatum has been implicated in the pathophysiology of ASD, which corresponds with an increase in repetitive behaviours and hyperactivity. ...

Welcome to SWEBAGS The Swedish Basal Ganglia Society, SWEBAGS, is an non-profit scientific organization providing a platform for discussions and education opportunities in the area of basal ganglia re...

Basal ganglia dysfunction potentially causes behavioral alterations in ASD. Carbonell-Roig et al. show that the eIF4E Tg mouse model of ASD exhibits behavioral inflexibility and impaired striatal dopa...

The substantia nigra pars reticulata (SNr), a crucial basal ganglia output nucleus, contains a dense expression of dopamine D1 receptors (D1Rs), along with dendrites belonging to dopaminergic neurons ...