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Brendan Bouffler ('boof') @boofla.bsky.social · 15/09/2026

Open weights, not open source. You can see the full episode of inside baseball (Supercomputing edition) on the 'tubes at @discoveredByCompute

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Brendan Bouffler ('boof') @boofla.bsky.social · 14/09/2026

OpenHPC is more than just an open source project. It's a career builder for thousands of IT professionals around the globe who now know how to build super computers. And that's quite a trick. #ai #hpc #scientificcomputing #opensource #supercompputer #supercomputing youtu.be/dSFhHjHOaRk

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Brendan Bouffler ('boof') @boofla.bsky.social · 14/09/2026

We just published our first edition of Inside Baseball ^H^H^H Supercomputing ... where we discussed many of the things that happened in the supercomputing world in the last month. Hope you like it please give it a try. lnkd.in/dgwz2_8B

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Brendan Bouffler ('boof') @boofla.bsky.social · 27/08/2026

HPC can't match the cloud's scale, but it can steal its ideas. How Los Alamos, NERSC, Bristol and CSCS brought cloud thinking on-prem. Link in bio. #ai #hpc #scientificcomputing #opensource #supercomputing

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Brendan Bouffler ('boof') @boofla.bsky.social · 26/08/2026

Every supercomputer starts the same way: someone has to get an operating system onto every node before anything else can happen. Travis explains how it's done across NERSC, Bristol and CSCS on both HPE and Dell hardware. #HPC #OpenSource #Supercomputing

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Brendan Bouffler ('boof') @boofla.bsky.social · 13/08/2026

El Capitan runs on Flux, which should tell you there's something interesting going on there. A lot of banks and core financial institutions should sit up and pay attention to this as well. #ai #hpc #scientificcomputing #opensource #supercomputing youtu.be/kZurarGmuNs

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Brendan Bouffler ('boof') @boofla.bsky.social · 07/08/2026

Building sftware in research can feel like a hazing ritual. Spack was created to address that, and so far the results have been amazing. youtu.be/eW0kK4PUKdY

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Brendan Bouffler ('boof') @boofla.bsky.social · 07/08/2026

He swore he'd never write a package manager. Then he built Spack. Full conversation on YouTube — link below #hpc #ScientificSoftware #supercomputing #opensource

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Brendan Bouffler ('boof') @boofla.bsky.social · 05/08/2026

Your mouse runs on thousands of open-source packages. Science relies on even more. How is AI changing that? #OpenSource #AI #HPC #SoftwareEngineering #ScientificComputing #TechExplained

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Brendan Bouffler ('boof') @boofla.bsky.social · 10/12/2025

Your next medicine will be designed by code, driven by AI. Dr Nathan Brown is working in the middle of all this. and gives us some great insights into the field, almost from an outsider's perspective. I really got a lot out of this discussion. I hope you do too. youtu.be/18ZcYxOQtaE

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Brendan Bouffler ('boof') @boofla.bsky.social · 26/11/2025

Quantum leaps in battery tech? Aionics is pushing the boundaries with their AI-powered material design. Dive into their HPC workflows on AWS to see how they're making it happen. # aws.amazon.com/blogs/hpc/ho...

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Brendan Bouffler ('boof') @boofla.bsky.social · 26/11/2025

Large behavioral models - yes, that's a thing.And the very smart people at the Toyota Research Institute have built one so it can set a breakfast table amongst other things. I talked with my buddy Tom Burggraf, who had the scoop on this, Very cool. www.youtube.com/watch?v=L7Ro...

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Brendan Bouffler ('boof') @boofla.bsky.social · 25/11/2025

Proteros implemented a scalable HPC solution for their Cryo-EM and PX workloads on AWS. Learn how they built secure cryoSPARC on AWS ParallelCluster with hybrid storage yo achieve high performance and low cost. aws.amazon.com/blogs/hpc/ho...

aws.amazon.com

How Proteros accelerates drug discovery by using AWS ParallelCluster | Amazon Web Services

Proteros is a leader in structure-based drug discovery solutions, and supports pharmaceutical, biotechnological, and academic clients with advanced technologies like Cryogenic Electron Microscopy…

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Brendan Bouffler ('boof') @boofla.bsky.social · 10/11/2025

SC'25 is almost upon us. In the rush to pack your bags, and get to the airport. don't forget some key things: (1) all our plans are posted on day1hpc.com/sc25/, our community is inhabited by amazing Women in HPC. #SC25 #WHPC

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Brendan Bouffler ('boof') @boofla.bsky.social · 10/11/2025

SC'25 is almost upon us. In the rush to pack your bags, and get to the airport. don't forget some key things: (1) all our plans are posted on day1hpc.com/sc25/, (2) our community is inhabited by amazing Women in HPC. #SC25 #WHPC

day1hpc.com

SC'24

AWS will be at SC'24 in Atlanta. Come meet with us.

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Brendan Bouffler ('boof') @boofla.bsky.social · 07/11/2025

We’re hosting a happy hour with our brothers in arms from (sorry couldn't resist), Arm and NVIDIA to welcome you to St Louis next weekend for SC’25. Beer and snacks are free. So is the awesome conversation. Registration is definitely essential. #AHUG #AWS hpc.news/ahug25

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Brendan Bouffler ('boof') @boofla.bsky.social · 07/11/2025

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Brendan Bouffler ('boof') @boofla.bsky.social · 06/11/2025

day1hpc.com

SC'24

AWS will be at SC'24 in Atlanta. Come meet with us.

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Brendan Bouffler ('boof') @boofla.bsky.social · 06/11/2025

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Brendan Bouffler ('boof') @boofla.bsky.social · 05/11/2025

Ørsted, a leader in offshore wind, partnered with AWS to tackle a complex thermal modeling challenge for their submarine cables. Discover how this proof-of-concept could drive more efficient operations and extend cable lifespan. aws.amazon.com/blogs/hpc/op...

aws.amazon.com

Optimizing undersea cables: how Orsted and AWS modeled seabed thermal properties | Amazon Web Services

This post was contributed by Ross Pivovar, Rafał Ołdziejewski, Cindy Xin Qi Lee Offshore wind farms play a critical role in the global transition to renewable energy and clean power generation. But…

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Brendan Bouffler ('boof') @boofla.bsky.social · 31/10/2025

Happy Halloween, fellow nerds. Hope the Deadlock DJ doesn't get you thios weekend. If he does, you're more than welcome to come and cry over a beer with us at SC'25. Booth #2207.

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Brendan Bouffler ('boof') @boofla.bsky.social · 30/10/2025

What kind of nerd are you? You can reveal your inner geek with us and tell us about the hard problems you're tryiong to solve that'll make the world generally nicer for all of us. We're att booth #2207 in the SC'25 expo hall. Or book a meeting with our exec yeam: day1hpc.com/sc25/

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Brendan Bouffler ('boof') @boofla.bsky.social · 29/10/2025

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Brendan Bouffler ('boof') @boofla.bsky.social · 28/10/2025

AWS Parallel Computing Service (PCS) is the third generation of Slurm-based HPC orchestrators, building on the foundations of CfnCluster and ParallelCluster. Learn about the key differences between these cloud-enabled HPC solutions. aws.amazon.com/blogs/hpc/th...

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Brendan Bouffler ('boof') @boofla.bsky.social · 28/10/2025

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Brendan Bouffler ('boof') @boofla.bsky.social · 27/10/2025

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Brendan Bouffler ('boof') @boofla.bsky.social · 24/10/2025

The road to SC'25: only four weeks to left. Come and meet our friendly AWS nerds who are eager to hear about the future you're building for all of us. We'll be at booth #2207 in the SC Expo hall. More details at day1hpc.com/sc25/

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Brendan Bouffler ('boof') @boofla.bsky.social · 23/10/2025

THis week on Tech Shorts, we discussed all of the under the hood improvements we've made to Research and Engineering Studio on AWS. youtu.be/MqmjOHlfUL8

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Brendan Bouffler ('boof') @boofla.bsky.social · 23/10/2025

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Brendan Bouffler ('boof') @boofla.bsky.social · 22/10/2025

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Brendan Bouffler ('boof') @boofla.bsky.social · 21/10/2025

Tired of extensive custom benchmarking for your HPC workloads? Our blog post offers a scientific approach to instance selection based on predictable resource patterns. Discover how to use our scoring framework to make informed decisions and save time. aws.amazon.com/blogs/hpc/a-...

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Brendan Bouffler ('boof') @boofla.bsky.social · 21/10/2025

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Brendan Bouffler ('boof') @boofla.bsky.social · 17/10/2025

What kind of HPC Nerd are you? Come to see us at SC'25 in St Louis, and tell us about the hard problems you're working on. Our nerds are ready to listen. #HPC #SC25 Details as they unfold at day1hpc.com/sc25

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Brendan Bouffler ('boof') @boofla.bsky.social · 17/10/2025

Slurm Accounting is like when Scarecrow got a brain at the end of Wizard of Oz: it makes for smarter decisions about job placement and execution in a busy HPC environment. Matt talks about how this works in this week's podcast. youtu.be/6KW2fD0yTgw

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Brendan Bouffler ('boof') @boofla.bsky.social · 16/10/2025

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Brendan Bouffler ('boof') @boofla.bsky.social · 16/10/2025

We've just released a massive dataset of 16,000+ protein-ligand complexes on AWS. Dive into the atomic-level dynamics and unlock new insights for drug discovery. #MachineLearning #StructuralBiology aws.amazon.com/blogs/hpc/da...

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Brendan Bouffler ('boof') @boofla.bsky.social · 15/10/2025

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Brendan Bouffler ('boof') @boofla.bsky.social · 14/10/2025

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Brendan Bouffler ('boof') @boofla.bsky.social · 13/10/2025

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Brendan Bouffler ('boof') @boofla.bsky.social · 09/10/2025

Wondering about which is which: Parallel Computing Service or ? They're not the same thing, and choosing the right one might save you a lot of work later. youtu.be/vB9GNWA5fws

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Brendan Bouffler ('boof') @boofla.bsky.social · 06/10/2025

AWS Parallel Computing Service (PCS) now offers expanded Slurm configuration capabilities. Customize over 65 parameters and apply settings to specific queue resources. Align your cloud HPC environment with your on-premises workflows. aws.amazon.com/blogs/hpc/an...

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Brendan Bouffler ('boof') @boofla.bsky.social · 02/10/2025

Tech Shorts is back. And appropriately. we're talking abnout how the tech we all help to create is supporting big positive changes in life sciences research. It's seriously nice to be back. Let's get nerdy. youtu.be/O7Ai5FLqG2s

youtu.be

arm64 is about to change life sciences ... dramatically

After a long break to recover from vision loss caused by my immune system, Tech Shorts returns. Appropriately, we're focusing on how cutting-edge compute can drive breakthroughs in life sciences.…

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Brendan Bouffler ('boof') @boofla.bsky.social · 30/09/2025

Tired of waiting for your on-premises EDA tools to churn through those massive design files? Let the cloud take the strain! Synopsys and AWS have the horsepower to get your chips to market faster. aws.amazon.com/blogs/hpc/se...

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Brendan Bouffler ('boof') @boofla.bsky.social · 23/09/2025

Cyclone chasing just got a whole lot smarter! Check out how DTN's AI-powered weather model is rewriting the forecast. Brace yourself for the future of weather prediction. aws.amazon.com/blogs/hpc/ho...

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Brendan Bouffler ('boof') @boofla.bsky.social · 19/09/2025

Boost your ML model training with reserved GPU power on AWS. AWS PCS now supports Capacity Blocks for EC2 instances like Hopper and Trainium. Simplify your HPC workloads with a fully managed service. #AWSPowered #HPC aws.amazon.com/blogs/hpc/an...

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Brendan Bouffler ('boof') @boofla.bsky.social · 11/09/2025

If you're an EDA / silicon designer & thinking about what's involved in scaling design and verification work, this panel talk might be really intrerestin to you. It's virtual, so you don't even need to leave your sofa (or beer). #HPC #EDA #CAE acceleratingsiliconinnovation2025.splashthat.com

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