iiinova — where your digital self keeps evolving

Dimitrije

@biodimi.bsky.social

21 followers 15 following 5 posts

I read, write and edit DNA Postoc at @geochurch.bsky.social lab (current), PhD with @marcguellc.bsky.social (past)

Posts Replies Media

Dimitrije @biodimi.bsky.social · 02/10/2025

@upf.edu @crg.eu @prbb.org

010

Dimitrije @biodimi.bsky.social · 02/10/2025

This work has been possible thanks to an incredible team effort w/ Alejandro, @marcguellc.bsky.social @noeliaferruz.bsky.social and the integra therapeutics team!

121

Dimitrije @biodimi.bsky.social · 02/10/2025

The improved variants are compatible with therapeutic T cell editing and Cas9-guided programmable integration. We also observed domain acquisitions in parts of the HyPB phylogeny. Stay tuned for future work on improving gene writing systems.🧬❇️

110

Dimitrije @biodimi.bsky.social · 02/10/2025

We explored and experimentally tested the natural diversity of PiggyBac transposases. We then used protein language models to enhance the efficiency of the current best PiggyBac transposase, Hyperactive PiggyBac.

110

Dimitrije @biodimi.bsky.social · 02/10/2025

Check out our latest work on the discovery and engineering of PiggyBac transposases! 🧵

1167