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Yiyun Chen Group

@bio-photochem.bsky.social
22 followers 9 following 6 posts

Prof. Yiyun Chen @ SIOC, CAS. Biocompatible photocatalysis — photochemistry that works in living cells & mice: uncaging, azide labeling, bioorthogonal catalysis.

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Yiyun Chen Group @bio-photochem.bsky.social · 02/10/2026
Our latest Account in Accounts of Chemical Research. Localize the photocatalyst, rather than the drug. Bioorthogonal photocatalytic deboronative hydroxylation enables localized pharmacology from subcellular compartments to neural circuits in vivo. doi.org/10.1021/acs....
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Yiyun Chen Group @bio-photochem.bsky.social · 24/08/2026
Thrilled that our @jacsau.bsky.social article is featured on THE Front Cover! We broke the distance & electronic limits of organoboron migration via visible-light excitation—a novel 1,5-boronate sigmatropic rearrangement to construct β-N-heterocycle alcohols. pubs.acs.org/doi/10.1021/...
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Yiyun Chen Group @bio-photochem.bsky.social · 30/11/2025
Our lab's cover in @angewandtechemie.bsky.social! It showcases our work on photocatalytic proximity techniques using localized catalysts. This includes precise drug release with miniature photoenzymes and bioorthogonal protein labeling via ketyl radicals.
onlinelibrary.wiley.com
Inside Back Cover: Miniature Photoenzyme Enables Organelle‐Specific Cellular Control via Deboronative Hydroxylation
A compact, genetically encoded photoenzyme, miniSOG, enables spatiotemporally controlled bioorthogonal deboronative hydroxylation of diverse organoboronates in live cells by producing localized super....
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Yiyun Chen Group @bio-photochem.bsky.social · 30/11/2025
Our latest work is out in @angewandtechemie.bsky.social: A miniature photoenzyme (12 kDa) uses visible light to achieve organelle-specific control in living cells via bioorthogonal deboronative hydroxylation. A powerful new platform for light-induced biological modulation.
onlinelibrary.wiley.com
Miniature Photoenzyme Enables Organelle‐Specific Cellular Control via Deboronative Hydroxylation
Genetically encoded miniature photoenzyme miniSOG (12 kDa) enables spatiotemporally controlled bioorthogonal deboronative hydroxylation of 27 diverse organoboronates in live cells via localized super...
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Yiyun Chen Group @bio-photochem.bsky.social · 30/11/2025
Our latest JACS @jacs.acspublications.org paper is out: Atomic-level precision protein labeling achieved in live cells using visible-light catalysis. This technology, based on stabilized ketyl radicals, provides a 'molecular ruler' to map protein dynamics and advance precision medicine.
pubs.acs.org
Bioorthogonal Photocatalytic Protein Labeling and Cross-Linking Enabled by Stabilized Ketyl Radicals
Radical reactions offer transformative potential in biological contexts but remain constrained by poor selectivity and off-target reactivity. We address these limitations through visible-light photoca...
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