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binwu1.bsky.social

@binwu1.bsky.social

Reposted by @binwu1.bsky.social

Nature Biotechnology @natbiotech.nature.com · 01/09/2026

A pervasive RT–qPCR artifact inflates RNA knockdown by RNA-targeting CRISPR - @binwu1.bsky.social @hopkinsmedicine.bsky.social www.nature.com/articles/s41...

nature.com

A pervasive RT–qPCR artifact inflates RNA knockdown by RNA-targeting CRISPR - Nature Biotechnology

A quantification artifact confounds CRISPR-mediated RNA knockdown.

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binwu1.bsky.social @binwu1.bsky.social · 01/07/2026

Excited to share that our collaboration with Oberdoerffer's lab at NIH has just published on @nature.com. www.nature.com/articles/s41.... We showed that the nucleotide modification ac4C enhances translation yield and fidelity of chemically modified synthetic mRNAs compared with industrial standard.

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binwu1.bsky.social @binwu1.bsky.social · 01/08/2025

Exited to share our recent publication by Ana De La Cruz from Johns Hopkins Biophysics. We visualized single mRNAs, their translation status and a regulatory factor in live cells.

embopress.org

Single-protein/RNA imaging reveals ZNF598 as a limiting factor in resolving collided ribosomes | The EMBO Journal

imageimageRibosomal quality control (RQC) ubiquitin ligase ZNF598 distinguishes transient ribosome collisions from permanent ones. Here, simultaneous imaging of protein-mRNA binding dynamics and trans...

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