iiinova — where your digital self keeps evolving

Bibek Gooptu @bibekgooptu.bsky.social · 05/03/2026

I certainly shall. We were already all big fans in this family but he’ll be thrilled!

Bibek Gooptu @bibekgooptu.bsky.social · 05/03/2026

@writerpoetjohn.bsky.social my little boy Kiran having a go at Ketchupface for #WorldBookDay. He was hoping some green shorts would arrive in time for what he had in mind. When they didn’t he woke me to say he was “sad as the saddest thing on earth”. Putting his bravest face on it here, mind

Bibek Gooptu @bibekgooptu.bsky.social · 29/11/2025

Very sad news to hear Prof Mike Morgan passed away yesterday. A fine clinician, a wise leader and a lovely human. He leaves a wonderful legacy in Leicester and Respiratory Medicine, but he will be greatly missed.

Bibek Gooptu @bibekgooptu.bsky.social · 12/08/2025

Creative, smart and charming: @apropostheatre’s #TheTruthAboutTrees inspired our kids’ leaf drawings. Strong impressions from a gentle and beguiling show. Go see it! The Crate, Assembly George Sq, 11.50. #EdFringe #EdinburghFringe #FringeForFamilies #EcoTheatre #FamilyTheatre

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Bibek Gooptu @bibekgooptu.bsky.social · 11/08/2025

Kids, parents, and grandma all very much enjoyed @ofalafel.bsky.social stupidest show. Wanna see a poo on a pogo stick, embellished by a bum-faced snail and a sausage bird? Course you do:

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Bibek Gooptu @bibekgooptu.bsky.social · 28/05/2025

Ciao and indeed ciao #Euroserpin2025, so sorry not to get longer in Brescia drawing insights and inspiration from you all, but had a great 24 hours even so!

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Bibek Gooptu @bibekgooptu.bsky.social · 28/05/2025

Oh, it’s been so much fun and I only got to attend for a session and a half! But cheering to think of crossing paths.

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Ellen Jenkins (UoB’ham) on a key question, how low does circulating oxygen drop in those with IPF overnight during sleep, & does that affect healthy lung cellular behaviour? 1st ans is: v signif’y low c/w controls. Bespoke antibodies and single-cell metabolic profiling, early findings => yes.

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Back after the coffee break. Prof Ian Sayers presenting preliminary digital spatial transcriptomics data on IPF & COPD. Part of UoL/UoN/UoCambridge @wellcometrust.bsky.social Discovery Award. Suggests that apparently normal areas of IPF lung have increased expression of disease implicated genes.

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There’s Rheum in the room - hurray and welcome, Prof Adam Croft! with cross-disciplinary insights. Dissecting pro-inflammatory and pro-resolution fibroblast behaviours in molecular and spatial detail. PRG4-deficient synovial fibroblasts behave like IPF myofibroblasts inc mφ interactions.

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Dr Chris Huntley presenting his research on the #SANDSTONE study => Is inhalable crystalline silica exposure a risk for sarcoidosis? Explored in cohort 2ry/3ry care cohort. Recruiting challenges over COVID era but now done. Adj’d OR 1.85 (lower limit of CI 1.01)! Lower exps c/w silicosis.

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Dr Bella Ng (Nottingham) focuses her research on innovative ways to use the latest MRI scanning methods to look at ILD when it affects children. Exciting to think how it might tell between fibrosis and inflammation, => crucial difference for treatment, and CT often can’t help.

Bibek Gooptu @bibekgooptu.bsky.social · 22/03/2025

#MIRA is up and running! Prof Louise Wain kicks us off outlining a streamlined entry system for patients who want to participate in research, actively or by allowing linkage of the information we collect clinically in any case. #LeicRespCohort

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I’m with @ksiva84.bsky.social’s response on this one. Subtle ‘beading of the fissure’ isn’t that specific, but this one ain’t subtle.

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ICS use also impairs IFN responses, neutrophils remain suppressed of course but worsening of MUC5AC/mucus viscosity and microbiome perturbation inc increased Strep carriage in vivo.

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Obese individuals have excessive inflammatory responses and impaired T1 IFN responses to diverse Resp viruses. Nice evidence to show that elevated leptin levels drive this via loss of SOCS2 suppression of JAK/Stat mediated cytokine release.

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Great to welcome Aran Singanayagam to bring us up to speed on his work looking at impaired or exaggerated Type-1 IFN pathways in the contexts of respiratory viruses and the inflammation they drive.

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We only abandoned our #GlenfieldRespTalks briefly during the initial phases of the COVID crisis, but only now really getting back to consistent in-person meetings. So it’s just so lovely to be back in our traditional venue. People homing back to their previous seats like swallows in summer…

Bibek Gooptu @bibekgooptu.bsky.social · 11/03/2025

Self-stabilising molecular systems inherently have potential to influence traits, evolve, and transmit information. Biomolecules co-evolved with cells. Nucleic acids specialised in the latter function. But the analogous properties remain. RNA w enzymatic functions, proteins as info transmitters…

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Bibek Gooptu @bibekgooptu.bsky.social · 06/03/2025

Thanks, she’s a huge fan and will be delighted!

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Bibek Gooptu @bibekgooptu.bsky.social · 13/02/2025

And we’re underway: now enrolled/randomised as first case! Congratulations to Amanda Charalambou and @nihr.bsky.social Leicester BRC team for making it happen, as well as the Leicester Rheum-Resp ecosystem.

Bibek Gooptu @bibekgooptu.bsky.social · 01/02/2025

Oh yeah, it’s also advanced understanding of multiple conditions caused by similar molecular mechanisms - from COPD to dementias! Quite good returns from its first 3 decades…. 🎉 👏🏽 🙌🏽 🪩 #MechanismMatters #BenchANDBedside 🧵 END (for now)

Bibek Gooptu @bibekgooptu.bsky.social · 01/02/2025

As a beneficial by-product they have helped the general development of novel strategies including iPSCs, RNA and gene-editing pushing the biotech for benefit across the board. 3/n

Bibek Gooptu @bibekgooptu.bsky.social · 01/02/2025

This has directly facilitated the range of new treatments now in clinical trials for alpha1-antitrypsin deficiency. 2/n

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Bibek Gooptu @bibekgooptu.bsky.social · 24/01/2025

Not a particular expert on this (and certainly not how I’d explain it to the patient) but I’d go for A.

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Bibek Gooptu @bibekgooptu.bsky.social · 14/01/2025

V happy to help screen first UK case for Scleroderma Research Foundation’s platform trial, assessing treatments for SSc-ILD, today #CurePF Plenty of Rheum in the ILD house (and vice versa), amiright @drpujamehta1.bsky.social?

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Reposted by Bibek Gooptu

Tom Calver @tomcalver.bsky.social · 29/12/2024

And the NHS actually spends less on things we consider “waste”, like admin and managers, than many other nations. The NHS may indeed be inefficient — but it is not “bloated”. Rather, it is inefficient because it is run too lean. More in my column 🔗 www.thetimes.com/article/1130...

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Bibek Gooptu @bibekgooptu.bsky.social · 27/12/2024

Agree. Presume you managed to figure that one out? But if not, can discuss off-platform, vaguely remember. Key in my institution is to identify someone helpful in grants admin team who can smooth the bumps. (But they’re not gonna be working over Uni holiday period.)

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Bibek Gooptu @bibekgooptu.bsky.social · 27/12/2024

1. No 2. I think it’s a way to formalise the primacy of finance in planning research. 3. Advise don’t copy/paste a costings total from Worktribe into another form. Think fields contain non-printing elements. Recently did this & was unable to figure out in time why submission wouldn’t go through 🥵

Bibek Gooptu @bibekgooptu.bsky.social · 26/12/2024

Happy to boost: @mariumnaqvi.bsky.social is one of the most active UK ILD specialist pharmacists. Part of a really dynamic (but not much on soc. media) team from Resp & Rheum across @gstt-nhs.bsky.social, and King’s College Hospital, @kingsresp.bsky.social, @kingscollegelondon.bsky.social

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Bibek Gooptu @bibekgooptu.bsky.social · 28/11/2024

And then I have the rest of the day to enjoy everyone else’s work and catch up with old & new friends. #RespIsBest

Bibek Gooptu @bibekgooptu.bsky.social · 28/11/2024

Presenting on behalf of ace erstwhile student Dr Charlie Hitchman… currently asleep I guess, ahead of a Louisiana Thanksgiving.