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Bharti Singal

@bhartisingal.bsky.social
60 followers 81 following 8 posts

Structural Biology, Biochemistry and Cell Biology, CryoEM, CryoET and FIB-SEM Cryo-EM staff scientist @Stanford University 🇺🇸 | Former-PostDoc @UCDavis 🇺🇸 | Alumni of @NTUSingapore 🇸🇬and @UniversityofDelhi 🇮🇳| She/her

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Bharti Singal @bhartisingal.bsky.social · 05/02/2025
www.nature.com/articles/s41... Beautiful work 👏👏
nature.com
Molecular sociology of virus-induced cellular condensates supporting reovirus assembly and replication - Nature Communications
Virus-induced cellular condensates are poorly understood. Using cryoET and cryoEM, the authors visualized the 3D “molecular sociology” of host-virus interactions and choreographed mammalian reovirus a...
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Bharti Singal @bhartisingal.bsky.social · 23/01/2025
I was still thinking about the quantum computing stocks and now we already have drug discovery pipeline with quantum computing algorithms 🙄🙄 These days I feel impossible to catch up with the pace of structural biology and drug discovery www.nature.com/articles/s41... 👏👏
nature.com
Quantum-computing-enhanced algorithm unveils potential KRAS inhibitors - Nature Biotechnology
A hybrid model combines quantum and classical approaches to generate compounds targeting the KRAS protein.
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Bharti Singal @bhartisingal.bsky.social · 12/01/2025
It was an amazing line up of speakers at the Cryo-EM: the next 50 years symposium. Meeting the pioneers in person and gaining insights for the future in CryoEM was the highlight of this meeting 👏
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Bharti Singal @bhartisingal.bsky.social · 10/01/2025
I think I can be rationally optimistic about 2025 😇🫶 This week so far is incredibly fruitful 🙏 This one thrown first time on grid and the protein complex is already screaming for data collection 🤞😎😇 P.S. - ignore the aggregates, we can deal with those later #SPA #cryoem
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Reposted by Bharti Singal
Ben Engel @cellarchlab.com · 06/01/2025
Towards community-driven visual proteomics! Excited to finally share this large-scale curated & annotated dataset of 1829 high-quality #cryoET tomograms of the little green alga that just keeps giving— Chlamydomonas! 🧪🧶🧬🌾🌊🌍 Preprint📜: www.biorxiv.org/content/10.1... A short thread🧵👇
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Bharti Singal @bhartisingal.bsky.social · 21/12/2024
In my role at Stanford, I wear many hats 🕵️‍♂️, but the most fulfilling of all is training and making the cutting edge tech accessible. Seeing my trainees/collaborators push boundaries in science is truly fulfilling and their kind words make me feel genuinely appreciated! Remembering teaching days. ❄️🔬☃️
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Reposted by Bharti Singal
Ben Engel @cellarchlab.com · 29/11/2024
Online @cellpress.bsky.social, we reveal a protein shell that helps diatoms fix 20% of global #CO2 🧪🌊🌾🧶🧬🌍 Shimakawa et al: www.cell.com/cell/fulltex... Nam et al: www.cell.com/cell/fulltex... @biozentrum.bsky.social press release: www.biozentrum.unibas.ch/news/detail/... Read on for more... 1/🧵
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Bharti Singal @bhartisingal.bsky.social · 18/12/2024
Just so proud of seeing these skinny babies at the end of long tedious sessions #waffleMilling #teamtomo It was my personal goal to learn FIB-SEM this year. A super kind researcher trusted and collaborated and gave me a driving force 🙏 this is where I am in 4th session on this sample. More to go
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bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 19/11/2024
Analysis of ribosomes from the Wild-type and FMR1 knockout human embryonic stem cells www.biorxiv.org/content/10.1101/202…
biorxiv.org
Analysis of ribosomes from the Wild-type and FMR1 knockout human embryonic stem cells https://www.biorxiv.org/content/10.1101/2024.11.18.624098v1
Fragile X Messenger Ribonucleoprotein 1 (FMRP) is a multifunctional, multidomain RNA-binding protein
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Bharti Singal @bhartisingal.bsky.social · 20/11/2024
Excited to share the collaboration project with Rohatgi lab at Stanford, recently published in Science www.science.org/doi/10.1126/...
science.org
Regulated N-glycosylation controls chaperone function and receptor trafficking
One-fifth of human proteins are N-glycosylated in the endoplasmic reticulum (ER) by two oligosaccharyltransferases, OST-A and OST-B. Contrary to the prevailing view of N-glycosylation as a housekeepin...
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