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Benoît Brilland @benoitbrilland.bsky.social · 22/01/2026

#interferon signature: doi.org/10.1016/j.ki... #prognosis signature: doi.org/10.1681/asn....

Benoît Brilland @benoitbrilland.bsky.social · 22/01/2026

Our large kidney transcriptomic dataset of #ANCA #glomerulonephritis is now publicly available (www.ncbi.nlm.nih.gov/geo/query/ac...). Used to describe a strong renal interferon signature and a prognosis signature outperforming current classifications (links below). I hope it will be useful! 🚀

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ASN Publications @asnpublications.bsky.social · 07/11/2025

Featuring this year's #ASNJASN Trainee of the Year's award-winning manuscript: "Identification of Renal Transcripts Associated with Kidney Function and Prognosis in ANCA-Associated Vasculitis" kidney.pub/JASN0779 @benoitbrilland.bsky.social @maineanjoureg.bsky.social

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Benoît Brilland @benoitbrilland.bsky.social · 07/11/2025

Using kidney transcriptomics, we identified a signature predicting renal survival in #ANCA #vasculitis, outperforming histopathology and opening the way to precision medicine. Thank you @asnpublications.bsky.social for highlighting our work... and for making the article 🔓 OPEN ACCESS 🔓 for 1 month!!

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Benoît Brilland @benoitbrilland.bsky.social · 07/11/2025

Honored that our work on renal transcriptomics in #ANCA -associated #vasculitis was selected for the #ASNJASN Trainee of the Year award. Very proud to represent the @maineanjoureg.bsky.social and @chuangers.bsky.social !

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Benoît Brilland @benoitbrilland.bsky.social · 09/09/2025

Using kidney transcriptomics, we identified a robust 12-gene signature predicting renal survival in #ANCA #vasculitis, outperforming histopathology, and opening the way to precision medicine. Thank you for the highlight @asnpublications.bsky.social !

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Maine-Anjou Research Group @maineanjoureg.bsky.social · 25/04/2025

Ex vivo #CRISPR-Cas9 knock out PR3 autoantigen in HSPCs prevents PR3-ANCA-driven neutrophil activation while preserving immune function. While aHSCT would still be required, this opens the door to sustained, drug-free remission in PR3 #ANCA #vasculitis! doi.org/10.1016/j.ki... @kidneyint.bsky.social

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Maine-Anjou Research Group @maineanjoureg.bsky.social · 01/04/2025

This new study shifts the focus from anti-MPO IgG to IgM in #ANCA -associated #vasculitis. IgM autoantibodies not only trigger potent complement activation but also dominate the autoreactive memory B cell pool—revealing a new pathogenic paradigm. Potential implications ⬇️

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Maine-Anjou Research Group @maineanjoureg.bsky.social · 01/04/2025

Targeting endothelial ferroptosis protects kidneys in #ANCA -associated #vasculitis, while systemic inhibition increases inflammation. This is why cell-specific therapies should be prioritised over blanket treatments! @kidneyint.bsky.social doi.org/10.1016/j.ki...

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Benoît Brilland @benoitbrilland.bsky.social · 29/03/2025

US 🇺🇸 nephrologists, immunologists, pathologists (et al.): there is a place for each of you in France 🇫🇷 … and especially in Angers if you like #vasculitis! www.nature.com/articles/d41...

nature.com

75% of US scientists who answered Nature poll consider leaving

More than 1,600 readers answered our poll; many said they were looking for jobs in Europe and Canada.

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Maine-Anjou Research Group @maineanjoureg.bsky.social · 24/03/2025

Kidney transplantation significantly improves survival in #ANCA-associated #vasculitis patients with end-stage kidney disease: 53% lower mortality risk. Our analysis from the french REIN registry ⬇️

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Benoît Brilland @benoitbrilland.bsky.social · 26/02/2025

Kidney transplantation significantly improves survival in #ANCA-associated #vasculitis patients with end-stage kidney disease: 53% lower mortality risk. Let's improve access to #KidneyTransplant! Read more in our analysis from the french REIN registry doi.org/10.1016/j.ek...

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Benoît Brilland @benoitbrilland.bsky.social · 31/01/2025

Welcome on Bluesky! @brixsilke.bsky.social @odlerb.bsky.social @thkc.bsky.social @paradise-project.bsky.social. I have included you in the « vasculits lovers » starter pack go.bsky.app/HFADD3c

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Benoît Brilland @benoitbrilland.bsky.social · 21/01/2025

Next International #Vasculitis Workshop host @anzvasc.bsky.social is now on Bluesky! See key dates below ⬇️

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Maine-Anjou Research Group @maineanjoureg.bsky.social · 08/01/2025

PEXIVAS post-hoc: no effect of reduced GC dose on kidney recovery in #ANCA #vasculitis. Faster kidney recovery with PLEX but not sustained beyond 3 months (better for subgroup GFR 15-30?). Real PLEX effect vs convection effect? @kronbichlerlab.bsky.social www.kidney-international.org/article/S008...

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Maine-Anjou Research Group @maineanjoureg.bsky.social · 06/01/2025

Infection is the top cause of death in #ANCA -associated #vasculitis, mostly during remission. Death certificates misreport causes, linking EHRs improves accuracy. We need to reduce infection risks through better immunosuppressive therapies www.sciencedirect.com/science/arti...

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Maine-Anjou Research Group @maineanjoureg.bsky.social · 17/12/2024

In #ANCA #vasculitis, 27% patients rated their health better or worse (≥ 20 PGA points) than their physicians did. This discordance highlights the need to address patients' perspectives to improve communication, shared decision-making, and care outcomes. pubmed.ncbi.nlm.nih.gov/39671122/

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Maine-Anjou Research Group @maineanjoureg.bsky.social · 12/12/2024

First AI-driven model for grading #ANCA -associated #glomerulonephritis lesions achieves 93% accuracy. Grad-CAM heatmaps align with pathologists’ focus, enhancing prognosis reliability. Bonus: the heatmaps look like colorful PET scans of glomeruli! www.kireports.org/article/S246...

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Maine-Anjou Research Group @maineanjoureg.bsky.social · 10/12/2024

Infections affect >50% of #ANCA -associated #vasculitis patients, with risk factors including diabetes, ESKD, kidney/lung involvement and treatment (methylprednisolone pulses, CYC, PLEX). Main site: respiratory system. Early risk management is crucial. doi.org/10.1016/j.au...

doi.org

Redirecting

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Maine-Anjou Research Group @maineanjoureg.bsky.social · 05/12/2024

Brace yourself, next Vasculitis Workshop is coming! Key dates: ✅ Abstract submission: 28 March - 19 September 2025 ✅ Workshop dates: 21 - 25 February 2026 📍 Melbourne, Australia vasculitis-melbourne2026.com

vasculitis-melbourne2026.com

IVW 2026 | 22nd International Vasculitis Workshop

Join the 22nd International Vasculitis Workshop, a leading event dedicated to advancing research, treatment, and understanding of vasculitis. Connect with global experts, researchers, and practitioner...

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The Conversation France @france.theconversation.com · 21/11/2024

Bonjour, bonjour, The Conversation France arrive sur Bluesky ! Ici, pas de breaking news tapageuses ni de buzz éphémères : on mise sur le fond, avec des articles écrits par des chercheurs et chercheuses qui savent de quoi ils parlent, en collaboration avec notre équipe d'excellents journalistes.

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Maine-Anjou Research Group @maineanjoureg.bsky.social · 02/12/2024

Results of the TAPIR trial: glucocorticoid discontinuation in GPA #ANCA vasculitis. ▶️ higher number of relapse at 6 months for the discontinuation group ▶️ but driven by minor relapses and by subgroup not treated but Rituximab. Presented by Pr. Peter Merkel #ACR24 (acrabstracts.org/abstract/a-m...)

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Benoît Brilland @benoitbrilland.bsky.social · 03/12/2024

Hi! Thanks for pinging. I think there is no one-size-fits-all answer. Would consider: - risk of relapse: GPA/PR3-AAV? ANCA titer overtime? eGFR (= « tolerability » of a future relapse)? Already relapsed? CD19 not that important imo - risk of SAE, esp. infections (frailty, comorbidities, IgG levels)

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Maine-Anjou Research Group @maineanjoureg.bsky.social · 26/11/2024

Reduced GC dose in #ANCA vasculitis: @terrierben.bsky.social confirms PEXIVAS results in real life: no difference in death/ESKD. Larger composite criteria [see table] (that may be discussed) in favor of standard GC dose, especially for RTX patients and severe AKI ard.bmj.com/content/earl...

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Maine-Anjou Research Group @maineanjoureg.bsky.social · 24/11/2024

Welcome in @terrierben.bsky.social. The #vasculitis family is growing here on Bluesky!

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Benoît Brilland @benoitbrilland.bsky.social · 20/11/2024

Moving from Twitter? Looking for #vasculits #glomerulonephritis lovers? Starter pack (work in progress): go.bsky.app/HFADD3c. Reply or DM to be added in the list!

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Benoît Brilland @benoitbrilland.bsky.social · 18/11/2024

My take: 🔹 for detailed emerging therapies, read the #PR3 review 🔸 for detailed pathogenesis, read the #MPO review

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Benoît Brilland @benoitbrilland.bsky.social · 18/11/2024

Two recent reviews of #ANCA vasculitis with wonderful graphics, and for the first time I think, #PR3 🔹 and #MPO 🔸 phenotypes considered in parallel but SEPARATELY! A new era with individualized treatment is coming for sure! 🔹 pubmed.ncbi.nlm.nih.gov/38574742/ 🔸 pubmed.ncbi.nlm.nih.gov/38574743/

bit.ly

Proteinase 3-specific antineutrophil cytoplasmic antibody-associated vasculitis

Proteinase 3 (PR3)-specific antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is one of two major ANCA-associated vasculitis variants a…

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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 17/11/2024

Related: if any of the Rheums are nephro adjacent and are interested in lupus, vasculitis stuff, there’s a GN/Vasculitis starter pack from @benoitbrilland.bsky.social go.bsky.app/HFADD3c Reply or ping him to be added!

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Benoît Brilland @benoitbrilland.bsky.social · 16/11/2024

Moving from Twitter? Looking for #vasculits #glomerulonephritis lovers? Starter pack (work in progress): go.bsky.app/HFADD3c. Reply or DM to be added in the list!

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