Human interferon-β (IFN-β), a type I IFN, is critical for effective innate immunity and is also an approved disease-modifying therapeutic. While genetic variations in several components of the type I ...

Rare autoantibodies neutralizing type I IFNs can underlie viral disease severity. Here, the authors dissect immunological and age-related factors associate

Rare autoantibodies neutralizing type I IFNs can underlie viral disease severity. Here, the authors dissect immunological and age-related factors associate

Autoantibodies neutralizing IFN-Is exacerbate severe viral diseases such as COVID-19. Here, the authors identify IFN-I regions commonly targeted by these a

Host body temperature can define a virus’s replicative profile—influenza A viruses (IAVs) adapted to 40° to 42°C in birds are less temperature sensitive in vitro compared with human isolates adapted t...

Author summary Host recognition of viral nucleic acids is fundamental for stimulating antiviral immunity. To prevent aberrant immune activation, cells must precisely differentiate “non-self” from “sel...

imageimageInfluenza A virus infection increases host transposable element (TE) expression. This study provides evidence that some infection-induced TEs form double-stranded RNAs that accumulate in the...

Interferons (IFNs) are a critical component of innate immune defenses and limit viral disease severity. To advance studies on IFNs and their neutralization by pathogenic autoantibodies, we generated ...

Type I IFN is vital for antiviral defense. Here, the authors use TurboID-based proximity labeling to comprehensively map the protein landscapes surrounding core IFN signaling members. Among factors un...