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The center also integrates AI-driven approaches to improve data analysis, model characterization, and cross-platform comparisons, helping establish more reliable and scalable organoid systems.

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SOM is tackling exactly this challenge by advancing reproducibility, validation, and standardization across the organoid field.

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Everyone is striving to build better and more complex organoid models—but do we appreciate the importance of standardized and validated models enough? Srivatsan Kidambi introduced us to NIH’s Standardized Organoid Modeling (SOM) Center!

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He also showcased the next-generation lung organoids containing epithelial, immune, and stromal compartments that can be maintained for up to 3 months. These models enable studies of SARS-CoV-2 infection and tissue-resident memory T cells, showcasing adaptive immune responses in organoids.

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Furthermore, intestinal organoids were used to study celiac disease, revealing gliadin-induced immune activation in the stroma and providing new insights into disease mechanisms.

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Particularly impressive were long-lived tumor microenvironment organoids retaining immune components, including TILs and TAMs. Fascinating data showing CD47 checkpoint inhibition increases SPP1 expression in both organoids and patients.

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Outstanding keynote by Calvin Kuo from @stanforduniversity.bsky.social on patient-derived tumor organoids, highlighting the importance of the stromal component!

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Iwan Jan talked about his work on modeling lens development in vitro. Transparent and in vivo mimicking organoids develop in a Celf1-dependent manner! @igdrennes.bsky.social

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Very interesting and directly translatable data from @andreasmoor.bsky.social identifying PlexinB2 as player behind liver cancer metastasis!

Ruben Lopez Sandoval presented his engineered intestine model to study host-microbe interactions. These microtissues secrete mucus and create an environment for Salmonella attachment!

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Alessandro Fiorenzano from University of Naples Federico II talked about how to generate A9 and A10 dopaminergic neurons!

Really exciting talk by Okikiola Morenike Olajide from @stanfordpress.bsky.social! Spleen organoids as a platform to study HIV-1 infection and generate B cells in vitro. A powerful step toward more predictive models for vaccine development and testing.

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Jose Silva from Guangzhou Laboratory virtually connected to BaCell3D to present his lab’s research on stem cell-based embryo models! Founder cells are key to create structures that contain heart, neural tube and even lung progenitors!

Beatriz Lopez-Amo Calvo from @uniinnsbruck.bsky.social highlighted replenishment response of neural progenitors in brain organoids!

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Andrea Banfi told us that engineering the signalling micro environment with angiogenic cues plays a decisive role in in vivo integration of mesenchymal stem cell-derived bone grafts! @unibas.ch

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Barbara Treutlein presented her lab’s groundbreaking work on morphogen and drug screening on brain, retina and intestinal organoids! @bsse.ethz.ch

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Giuliana Rossi from Roche Institute of Human Biology presented her work on establishing NAMs for teratogenicity testing!

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Karoliina Pelttari from @unibas.ch presented their work on generating cartilage microtissues from patient-derived tissues. Metabolism plays an important role in chondrogenic differentiation!

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Furthermore, he showed that hiPSCs can be coaxed into multiple neuron subtypes by tweaking the differentiation induction signals! WNT inhibition for 2 days makes a big difference!

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Particularly striking were the data demonstrating the pre-determined differentiation of human iPSCs into vagal and non-vagal neural crest cells.

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His lab continues to refine differentiation protocols for generating diverse neuronal cell types, including those of the enteric nervous system.

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An inspiring keynote by Lorenz Studer from @mskcancercenter.bsky.social showcasing the complete journey of a cell therapy—from in vitro stem cell differentiation to clinical trials. Particularly exciting were the data demonstrating significant improvements in Parkinson’s disease symptoms!

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@hausmannannika.bsky.social from @ethz.ch talked on the importance of cellular crosstalk in maintaining intestinal homeostasis and driving inflammation. Particularly impressive were the deep visual proteomics images!

Daphne Bouwens from @rwth.bsky.social presented how kidney organoids can be used to study kidney fibrosis. When combined with single-cell RNA-seq atlases across disease-mimicking conditions, organoids enable identification of molecular drivers and pathways underlying fibrotic disease.

Inspiring talk by Abdullah Khan from @ox.ac.uk on combined bone and bone marrow organoids (comBO). The model enables study of hematopoietic stem cell maintenance and offers insights into disease mechanisms in myelofibrosis and multiple myeloma!

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Talk by Liliana Santos-Ferreira (@i3suporto.bsky.social) on the role of glycosylation in gastric cancer. Patient-derived organoids faithfully recapitulated therapy resistance seen in patients, with fucosylation-related pathways among the most differentially expressed.

Karolin Stumpf from @dkfz.bsky.social presented her work on bone marrow organoids in the context of AML (acute myeloid leukemia) engraftment. The model provides a powerful system to study how leukemic cells interact with and colonize the bone marrow niche.

@juliabatki.bsky.social showed that extraembryonic gut cells are eliminated during mouse development through a p53-dependent cell death and are subsequently phagocytosed by embryonic gut cells. A beautiful example of how precise cellular clearance shapes embryonic development!

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Fascinating work from Carla Rosell (@bsse.ethz.ch) on pleural mesothelioma. Patient-derived organoids are enabling personalized therapy selection and showing superior tumoroid killing compared with standard chemotherapy.

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Ellen Fritsche from SCAHT discussed guidelines for developing New Approach Methodologies (NAMs) for toxicology testing. She highlighted neurospheres as valuable in vitro models for studying developmental neurotoxicity as they can provide mechanistic insights without relying on animal testing.

2D cultures favor pit-like cells, while 3D organoids develop glandular features with high Wnt activity. Particularly exciting were TissUse chips combining patient-derived stomach organoids with liver tissue to reveal patient-specific responses to prodrugs—a promising step toward precision medicine.

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Fascinating presentation by Sina Bartfeld from @tuberlin.bsky.social on gastric organoids and H. pylori. Human and mouse GI biology differ substantially, including innate immune signaling, highlighting the need for human-relevant models.

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Interesting talk from @oieretxezarreta.bsky.social on the role of T cells in the gut and their contribution to colonocyte inflammation. Validation studies in organoid models showed that treatment with T-cell-derived factors disrupted epithelial integrity.

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Maryam Asadikorayem from @uzh-ch.bsky.social presented her work on culturing skin biopsies in vitro. Thin slices survive 7 days in culture and maintain cell type architecture!

BaCell3D @bacell3d.bsky.social · 22/06/2026

Thank you to everyone who participated in the lively first poster session ahead of our networking dinner at KLARA ✨

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We welcome all our participants to Basel for the 5th edition of BaCell 3D! We‘re excited for a dense three day program full of cutting-edge science and socializing 🌞

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Reposted by BaCell3D

Ingrid Tsang @ingridtsang.bsky.social · 22/06/2026

Super excited to be in sunny Basel for @bacell3d.bsky.social this week!🌞Feel free to come say hi at the Meet the Editors tables during tomorrow and Wednesday's coffee breaks 👋

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BaCell3D @bacell3d.bsky.social · 22/06/2026

The workshops ahead of the BaCell 3D are kicked off at the @biozentrum.unibas.ch 🥳 We‘re excited to host a wide variety of facilitators this year, from grant writing, organoid imaging, to personal development.

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BaCell3D @bacell3d.bsky.social · 17/03/2026

The deadline for the Science Bridging Program is approaching ⏳ Apply by March 29 to receive financial support for attending #BaCell3D2026 in Basel, Switzerland. conferences.unibas.ch/frontend/ind... We look forward to receiving applications from around the world 🌍🗺️

conferences.unibas.ch

Home – Science Bridging Programm 2026

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BaCell3D @bacell3d.bsky.social · 10/03/2026

🌉 Science Bridging Program – Deadline approaching Researchers who might otherwise be unable to attend are encouraged to apply for financial support. Don’t miss this opportunity! conferences.unibas.ch/frontend/ind...

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BaCell3D @bacell3d.bsky.social · 10/03/2026

🚀 The #BaCell3D2026 speaker lineup is here! We are excited to welcome an outstanding group of experts in organoids and advanced 3D cellular systems to Basel this June! ⏳Our meetings tend to fill up quickly, so we encourage you to secure your spot early: conferences.unibas.ch/frontend/ind...

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BaCell3D @bacell3d.bsky.social · 10/03/2026

lnkd.in

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BaCell3D @bacell3d.bsky.social · 10/02/2026

We are pleased to announce the continuation of the Science Bridging Program at #BaCell3D2026, offering financial support grants to attendees who are coming from underrepresented countries or newly established laboratories. Application deadline is on March 20!⌛ conferences.unibas.ch/frontend/ind...

conferences.unibas.ch

Home – Science Bridging Programm 2026

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Reposted by BaCell3D

ISSCR @isscr.org · 03/10/2025

Join @stemcellreports.bsky.social and @bacell3d.bsky.social on 4 November to learn how organoid models are being used to study human development, infection, tissue dynamics, and cancer across various organ systems. Features Short Talk Winners! Register today👉 bit.ly/4o46DzZ

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BaCell3D @bacell3d.bsky.social · 08/09/2025

Join us on November 4th! The winners of our best short talk awards will be telling their research on the @isscr.org stage! Thank you @stemcellreports.bsky.social for co-organizing this webinar!

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BaCell3D @bacell3d.bsky.social · 01/07/2025

Tina Buerki-Thurnherr from EMPA talked about the effect of nanoparticles on in vitro models of placenta