Borges, González-Blanco, Arigela, et al. report new missense mutations in the PRC1 genes RNF2 and RING1 in individuals with neurodevelopmental disorders. Functional dissection of a deleterious variant...

This research provides powerful new tools to rapidly study adenovirus gene expression and replication. By integrating fluorescent and secreted luciferase reporters into native viral regulatory element...

Fred Hutch is dedicated to the elimination of cancer and related diseases as causes of human suffering and death.

HCMV rearranges the host cell to produce infectious virus but molecular details are still unclear. Here, the authors analyze the transcriptome of infected cells and show that HCMV turns on dormant neu...

Marine creatures house contraband structures in special organelles, which the animal raids for food in times of need.

Investigating viral manipulation of host chromatin dynamics