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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 22h

GP2’s workshop in Buenos Aires brought 28 trainees from seven countries together to explore family-based genetic analysis, introduced into GP2’s training program for the first time. Trainers and trainees share highlights and reflections in a new blog. 🔗 Read more: bit.ly/3TPxjLc

Group photo of GP2 Buenos Aires training workshop participants standing together in a library with wooden bookshelves, framed by a blue-to-green border.

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 07/10/2026

We’re pleased to welcome Alberto Ascherio, MD, DrPH; Russ Altman, MD, PhD; and Walter Koroshetz, MD, to ASAP’s Scientific Advisory Board. Their perspectives augment the board's expertise as ASAP’s work continues to evolve and advance collaborative #Parkinsons research.

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 06/10/2026

🧠 CRN Team Tansey is studying how immune system aging may contribute to Parkinson’s risk and differences in how the disease develops. The team will examine immune cell exhaustion, aging, and infections. 🔗 bit.ly/4c6rj6P

CRN Team Tansey graphic titled “Immune Aging and Parkinson’s Disease Risk.” The team investigates how immune cell exhaustion develops with age and may contribute to Parkinson’s disease risk and progression. Headshots show lead principal investigator Maria de Lourdes Tansey, PhD, and co-principal investigators Elizabeth Bradshaw, PhD; Richard Smeyne, PhD; Rebecca Wallings, PhD; and Catherine Weindel, PhD.

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 06/10/2026

The GP2 Regional Investigators Meeting in Seoul brought together researchers across Asia & Oceania to tackle challenges in #Parkinsons genetics 🌍 Highlights: 🌟 Trainee talks & Poster Prize winners 📊 Asian/Oceania GWAS updates 🤝 GP2 URP Working Group strategy Thanks to everyone who attended!

Two attendees wearing GP2 lanyards talk during a poster session, while other participants converse beside research posters in the background.

Three attendees wearing GP2 lanyards converse during a refreshment break, with two holding plates of food and another gesturing.

A large group of GP2 meeting attendees pose together onstage, smiling and making finger-heart gestures beneath Global Parkinson’s Genetics Program branding.

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 02/10/2026

For 20 years, LARGE-PD has united researchers and patients to advance #Parkinson’s research in Latin America. With GP2’s support, it has grown to 15 countries & 10k participants. In a new blog post, Ignacio Mata, PhD, reflects on its impact and community. 🔗: bit.ly/4AEw0PK #HispanicHeritageMonth

The presenter speaks into a microphone at a podium, with slides about LARGE-PD and recruitment efforts in Latin America displayed behind him.

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 01/10/2026

A new GP2 #blog recaps GP2’s Regional Investigator Meeting in Nairobi, sharing research updates from teams advancing #Parkinsons genetics research across the continent and perspectives from six African GP2 trainees. 🔗 Read more: bit.ly/4rN43kY

A speaker stands at a podium beside four seated panelists in front of a GP2 backdrop.

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 30/09/2026

This month’s Discover ASAP features Nolwazi Gcwensa, MSc, PhD, on SynDOVE, an accessible protocol for studying synaptic proteins in 3D using confocal microscopy. 🔬 The approach can reveal changes that 2D analysis may miss, offering new insights into #Parkinsons. 📺 Watch: bit.ly/4z5OvuP

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 29/09/2026

TeamTuesday 🧠 CRN Team Parisiadou is studying how RNA damage and ribosomal dysfunction contribute to dopamine neuron vulnerability in #Parkinson’s. By identifying early disease pathways, the team aims to uncover potential targets for new treatments. 🔗 bit.ly/4wEFiId

Graphic introducing Team Parisiadou’s research on RNA oxidation and ribosomal dysfunction in Parkinson’s vulnerability. The team includes Lead PI Loukia Parisiadou, PhD, and Co-PIs Elisa Greggio, PhD; Daniel Arango, PhD; Sabine Hilfiker, MD; and Mark Cookson, PhD.

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 28/09/2026

🌐 September’s #OpenScience Champion is Ines Rodrigues-Vaz, PhD, of CRN Team Surmeier! She’s shared 30+ TB of histology, behavioral, and in vivo imaging data in discipline-specific repositories, while developing protocols and helping ensure the accuracy of shared resources.

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 23/09/2026

A new GP2 #blog explores how cross-cultural research strengthens global collaboration. Beatriz Muñoz Ospina shares how the Visiting Scientist Program brought her from Colombia to London to study cognition across diverse populations. 🔗 bit.ly/4itK3RH

Four researchers pose for a photo in front of an East London Parkinson’s Disease Project banner.

GP2 Visiting Scientist Beatriz Muñoz Ospina points to a Wolfson Institute of Population Health sign at Queen Mary University of London.

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 22/09/2026

For this week's #TeamTuesday, we're highlighting CRN Team Krichevsky's work on how RNA shapes brain resilience in aging and #Parkinsons. By examining why some brain cells withstand disease better, the team aims to uncover ways to protect neurons and slow Parkinson’s progression. bit.ly/4xTjiKM

Graphic introducing Team Krichevsky’s research on RNA mechanisms in Parkinson’s resilience and vulnerability. The team is investigating how RNA changes influence neuronal survival, protein pathology, and Parkinson’s progression. Team members pictured are Anna Krichevsky, PhD, Lead PI; YuHong Fu, PhD, Co-PI; Erinc Hallacli, PhD, Co-PI; Glenda Halliday, PhD, Co-PI, and Vikram Khurana, MD, Co-PI.

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 21/09/2026

The team also examined how the LRRK2(G2019S) variant affects iron homeostasis, NCOA4 trafficking, and ferroptotic cell death under iron overload conditions. bit.ly/4x3vQP2

LRRK2 G2019S cells are hypersensitive to iron-induced oxidation and ferroptotic cell death.

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 21/09/2026

Team Desjardins tested whether mild gastrointestinal infection can affect blood-brain barrier integrity and brain inflammation in Pink1 knockout and wild-type mice. bit.ly/4gSsAQy

Upregulation of inflammation-related striatal transcription in Pink1 KO mice following Citrobacter rodentium infection.

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 21/09/2026

The team also examined how the LRRK2(G2019S) variant affects iron homeostasis, NCOA4 trafficking, and ferroptotic cell death under iron overload conditions. bit.ly/4x3vQP2

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 21/09/2026

Team Desjardins tested whether mild gastrointestinal infection can affect blood-brain barrier integrity and brain inflammation in Pink1 knockout and wild-type mice. bit.ly/4gSsAQy

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 18/09/2026

As #OpenScienceWeek wraps up, hear from researchers across ASAP on how open data, shared tools, and collaboration advance #Parkinsons research. ASAP’s open science work also informs broader efforts alongside our management organization, @aligningscience.com. 🔗 Read more: bit.ly/4Am002y

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 17/09/2026

What can open science unlock before a paper is even published? 🔬 For #OpenScienceWeek, Daniel Dautan (@2dneuro.bsky.social), PhD, of CRN Team Kaplitt shares how early data sharing sparks cross-team replication dialogue, helping hone protocols & analysis, strengthening reproducibility in real time ⬇️

Open Science Week quote graphic with a light, abstract network-pattern background and blue accents. A large blue “01” appears on the left, with the question at the top: “How has open science helped you share your work and access, reuse, or build upon research from others?” Below a thin blue divider, Daniel Dautan, PhD, responds: “Before our manuscript was even submitted to a journal, sharing our raw data had already prompted discussions and meetings with other CRN teams to explore replication of our model. This exchange facilitated discussions regarding the presence of pSer129 signal in healthy control animals and the appropriate protocols and procedures to follow for IHC.”

Open Science Week quote graphic with a dark navy and blue abstract network-pattern background. A large blue “02” appears on the left, with the question in white at the top: “How can open science help move Parkinson’s discoveries closer to better treatments, care, or everyday outcomes?” Below a thin blue divider, Daniel Dautan, PhD, responds: “Sharing raw data and discussing protocols and methodology allowed us to evaluate our results and identify potential sources of variability. Sharing detailed protocols also helped us learn from one another and improve our understanding of differences observed across groups, ultimately strengthening the robustness and reproducibility of our findings.”

Open Science Week quote graphic with a light, abstract network-pattern background and blue accents. A large blue “03” appears on the left, with the question at the top: “How has access to another researcher’s data, methods, tools, or resources influenced the direction of your own work?” Below a thin blue divider, Daniel Dautan, PhD, responds: “We improved our IHC protocol to enhance the signal and refined the analysis script following discussions during a CRN meeting. These improvements allowed us to better account for basal signal as a baseline, thereby improving the accuracy and robustness of our analyses.”

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 16/09/2026

Why does scale matter in #Parkinsons genetics? 🌍 For #OpenScienceWeek, Christine Klein, MD, of GP2 shares how harmonized datasets and shared tools can connect rare Parkinson’s cases across countries, reveal signals hidden in smaller cohorts, & inform research relevant to trials ⬇️ #ScienceForAll

Open Science Week quote graphic with a light, abstract network-pattern background and green accents. A large green “01” appears on the left, with the question at the top: “How has open science helped you share your work and access, reuse, or build upon research from others?” Below a thin green divider, Christine Klein, MD, responds: “MDSGene, built and curated in Lübeck, turns the scattered monogenic movement disorders literature into structured, queryable variant and phenotype records. We are now merging it with GP2 cohort data for aggregated cross-resource summaries neither could offer alone.”

Open Science Week quote graphic with a dark navy and green abstract network-pattern background. A large green “02” appears on the left, with the question in white at the top: “How can open science help move Parkinson’s discoveries closer to better treatments, care, or everyday outcomes?” Below a thin green divider, Christine Klein, MD, responds: “Open sharing through GP2/ASAP pools rare monogenic variant carriers across continents—the only way to power penetrance, age-at-onset, and conversion questions that LRRK2, GBA1, and PRKN trials depend on. Openly harmonized cohorts and phenotypes let findings from one site reach clinics and trial designers everywhere.”

Open Science Week quote graphic with a light, abstract network-pattern background and green accents. A large green “03” appears on the left, with the question at the top: “How has access to another researcher’s data, methods, tools, or resources influenced the direction of your own work?” Below a thin green divider, Christine Klein, MD, responds: “GP2’s openly shared NIH Oxford Nanopore pipeline reshaped which structural variants and repeat expansions we can validate. Openly harmonized cross-ancestry GP2 releases let our Family Analysis Working Group prioritize candidate genes visible only in pooled data—genes we would never have identified from families we had access to alone.”

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 15/09/2026

What changes when researchers can build on one another’s work earlier? 🔓 For #OpenScienceWeek, Hina Ojha, PhD, of CRN Team Muqit shares how early access and cross-lab collaboration can spark new directions and strengthen #Parkinsons research ⬇️ #ScienceForAll 🧪

Open Science Week quote graphic with a light, abstract network-pattern background and purple accents. A large purple “01” appears on the left, with the question at the top: “How has open science helped you share your work and access, reuse, or build upon research from others?” Below a thin purple divider, Hina Ojha, PhD, responds: “Open science gives access to work that might otherwise stay hidden for months through peer review, publication delays, or negative results. Platforms like bioRxiv let us see, question, and build on findings earlier. In disease research, where every moment counts, that early access can spark an important new direction.”

Open Science Week quote graphic with a dark navy and purple abstract network-pattern background. A large purple “02” appears on the left, with the question in white at the top: “How can open science help move Parkinson’s discoveries closer to better treatments, care, or everyday outcomes?” Below a thin purple divider, Hina Ojha, PhD, responds: “For a long time, science rewarded labs for competing and protecting their work, and sometimes we lost sight of why we entered the field: to understand disease and help patients. Initiatives like ASAP have pushed us to collaborate and opened many eyes to how much faster and better science can move when we work with, rather than against, each other.”

Open Science Week quote graphic with a light, abstract network-pattern background and purple accents. A large purple “03” appears on the left, with the question at the top: “How has access to another researcher’s data, methods, tools, or resources influenced the direction of your own work?” Below a thin purple divider, Hina Ojha, PhD, responds: “Collaboration taught me that you do not need the burden of knowing everything. In some projects, another lab brought the biology while I contributed structural insight. Each of us brought what we did best, and together the work became something neither could have achieved alone.”

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 14/09/2026

ASAP celebrates #OpenScienceWeek! ASAP has long put open science into practice to strengthen collaboration, expand access, and accelerate discovery, informing broader efforts alongside our management organization, @aligningscience.com. Watch 3 researchers share what that looks like: bit.ly/4xTbBVc

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 11/09/2026

We’re excited to welcome Andres Leschziner, PhD, from Weill Cornell Medicine, as the September LRRK2 Central #webinar speaker. 👇 Reserve your spot using the link below. 📅 September 24, 2026 ⏰ 1:00 PM ET RSVP: bit.ly/4hn25nv

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 09/09/2026

GP2’s Regional Investigator Meeting in Montevideo celebrated the power of collaboration in #ParkinsonsDisease research. We also marked the 20th anniversary of the LARGE-PD consortium, now 73 sites strong. Thanks to everyone for the insights & energy to accelerate genetic discovery in Latin America!

Six panelists sit onstage during a GP2 and LARGE-PD session titled “Recruitment, Patient Involvement, and Equity at Scale,” with large blue presentation screens behind them.

A large group of GP2 and LARGE-PD meeting attendees gather closely together on a staircase for a group photo, many smiling and making peace signs.

A large audience of GP2 meeting attendees sits at conference tables, many applauding and smiling during a session.

Three conference attendees speak together beside a scientific poster examining Parkinson’s disease, pesticide exposure, and gene-environment interactions across populations.

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 03/09/2026

🎉 The 2026 CRN Annual Investigators Meeting brought ASAP’s global research community together to accelerate progress in #Parkinsons research. By connecting teams across disciplines, datasets, & research questions, the meeting underscored how collaboration can help advance discovery. bit.ly/4h4P6qt

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 02/09/2026

Team De Camilli used cryo-EM to resolve the structure of VPS13C, a Parkinson’s-linked lipid transfer protein, and identified potential calcium/calmodulin regulation. 🔗 bit.ly/3U7OnvQ

Cryo-EM structure of soluble VPS13C suggests its regulation by a conformational switch and by calmodulin.

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 02/09/2026

Team Harper examined DNAJC13/RME-8 structure and function, offering a mechanistic framework for understanding recycling endosome regulation. 🔗 bit.ly/4gSf7sU

Structural architecture of DNAJC13 by cryo-EM.

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 02/09/2026

Team Hardy used serum proteomics to identify proteins associated with later progression to Parkinson’s disease dementia, pointing to possible early markers of risk. 🔗 bit.ly/4xmXZl9

Study Design, including the study population and overview of the statistical analyses performed.

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 02/09/2026

Team Hafler developed a high-throughput optical screening system to identify small molecules that can modulate intracellular α-synuclein aggregation, including harman. 🔗 bit.ly/4wJvaOr

Differential expression and pathway enrichment analyses reveal transcriptional changes associated with harman exposure (A-C). (Rothschild et al., 2026).

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 01/09/2026

#TeamTuesday 🧠 CRN Team Keller is studying the molecular mechanisms linking aging and Parkinson's across brain cell types, sexes, and species. Using multi-omics, machine learning, and functional genomics, the team aims to identify key genes and small RNAs that drive disease. 🔗 bit.ly/3SnfBhu

Graphic introducing Team Keller’s research on mapping molecular networks in Parkinson’s disease. The team is investigating how age, sex, brain cell type, and species shape the genes and small RNAs that drive Parkinson’s. Team members pictured are Andreas Keller, PhD, Lead PI; Philip De Jager, MD, PhD, Co-PI; Tal Iram, PhD, Co-PI; and Vilas Menon, PhD, Co-PI.

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 31/08/2026

🔓 Open science is central to how we work year-round. Across our network, researchers share data, tools, protocols, and other resources so others can access, test, reuse, and build on new discoveries. Stay tuned as we look ahead to #OpenScienceWeek, Sept. 14–18.

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 28/08/2026

This month’s Discover ASAP features Madeline Klinger, PhD, with Korbin Kleczko, BS, of CRN Team Harper 🧪 They share Q-DOAS, a proximity-quenching assay that detects early protein aggregation in real time, giving researchers a new tool to study α-synuclein and #Parkinsons. bit.ly/4zFOuyP

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 27/08/2026

What can global collaboration & open science make possible for Parkinson’s research? The 2025–2026 CRN Impact Report highlights findings from: 🔬 500+ papers & preprints 🧰 140+ open access lab resources 💾 92 TB of harmonized multi-omics data 🤝 100+ scientific exchanges bit.ly/4zKeJV2

Graphic with a purple-to-blue gradient background and white text reading, “ASAP Collaborative Research Network Impact Report 2025–2026.”

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 25/08/2026

For this Team Tuesday, we are highlighting CRN Team Barker's work on how aging-related changes in DNA organization may contribute to #Parkinsons heterogeneity. Their work focuses on heterochromatin erosion, single-cell epigenomics, and cell-based Parkinson-aging models. 🔗 bit.ly/4xA4Ebk

Graphic introducing Team Barker’s research on aging-related DNA changes in Parkinson’s disease, led by Roger Barker, PhD, with co-PIs Johan Jakobsson, PhD; Annelies Quaegebeur, MD, PhD; Lorenz Studer, MD; and Eides Zenk, PhD. The team is investigating how heterochromatin erosion may contribute to disease progression and selective cell vulnerability.

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 24/08/2026

🧬 Aging is a key risk factor for #ParkinsonsDisease. Three new CRN teams are exploring how aging-related changes may shape disease onset, progression, and heterogeneity across people and cell types. Their work aims to uncover new mechanisms and therapeutic opportunities. 🔗 bit.ly/4yPrCwA

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 21/08/2026

A large-scale sequencing preprint analyzed data from more than 38,000 people across 11 genetic ancestries to map repeat expansions associated with Parkinson’s disease and parkinsonism. 🔗 Read the #preprint: bit.ly/4i8dkAW

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 21/08/2026

A POLG-focused preprint examined variants across diverse ancestries, identifying five Parkinson’s cases with potentially biallelic pathogenic or likely pathogenic variants. 🔗 Read the #preprint: bit.ly/4zcVpiO

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 21/08/2026

One preprint generated multi-omic data from 3.3M+ nuclei across five brain regions, mapping cell-type-specific features and using machine learning to identify rare noncoding variants linked to Parkinson’s. 🔗 Read the #preprint: bit.ly/4wG9OSl

Multi-omic profiling of postmortem human brain yields high-quality and high-depth data across 101 donors.

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 20/08/2026

A global brain bank study found that misdiagnosis and Alzheimer’s disease copathology were common. GBA1 and LRRK2 variants were also associated with different levels of Lewy body pathology. 🔗 Read the #publication: bit.ly/4bwaPVh

Stacked Bar Plots Showing the Distribution of Lewy Body Disease (LBD) Subtype and Braak Neurofibrillary Tangle (NFT) Stages by Variant Group in Individuals With LBD.

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 20/08/2026

Using data from more than 25,000 people with Parkinson’s, researchers found that limiting genetic testing to people with an age at onset of 50 or younger may miss many LRRK2 and GBA1 variant carriers. 🔗 Read the #publication: bit.ly/4xlgA0n

Bar Graph Showing Age Bracket Performance of Age-at-Onset (AAO) Criteria for Genetic Testing in Parkinson Disease (PD).

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 20/08/2026

Researchers found that genetic ancestry and country of origin were associated with the age at onset of LRRK2 p.Gly2019Ser-related Parkinson’s, suggesting that genetic and environmental factors may both play a role. 🔗 Read the #publication: bit.ly/4xl8yV4

The Age at Onset of LRRK2 p.Gly2019Ser Parkinson's Disease Across Ancestries and Countries of Origin.

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 19/08/2026

Parkinson’s is not one disease, and treating it as one may limit progress. In Bio-IT World, ASAP Managing Director and @aligningscience.com COO Sonya Dumanis, PhD, explores how biomarkers, molecular stratification, and open science can move the field toward precision medicine. 🔗: bit.ly/4hzVKWw

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 18/08/2026

#TeamTuesday 🧠 CRN Team Petrucelli is investigating molecular modifiers of co-pathologies in #Parkinsons disease. Their work examines how alpha-synuclein, TDP-43, amyloid beta, and tau may interact to influence disease outcomes and progression. 🔗 bit.ly/3S6MleG

Team Petrucelli graphic titled “Identifying Molecular Modifiers of Parkinson’s Co-Pathologies,” featuring lead investigator Leonard Petrucelli and co-investigators Evan Macosko, Benjamin Ryskeldi-Falcon, Michael Ward, and Yongjie Zhang. The team maps overlapping protein pathologies in Parkinson’s disease and Parkinson’s disease dementia.

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 17/08/2026

GP2 researchers evaluated Parkinson’s polygenic risk scores in Latin American populations, underscoring the need for larger ancestry-matched studies to strengthen multi-ancestry risk prediction. 🔗 Read the #preprint: bit.ly/3THJlGb

Cross-ancestry performance of Parkinson’s disease polygenic risk scores in admixed Latin American populations.

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 17/08/2026

A genome-wide study of young-onset Parkinson’s identified common and low-frequency variants that may contribute specifically to this subgroup, supporting its role as a partly distinct subphenotype. 🔗 Read the #preprint: bit.ly/460laFv

Miami plot of additive and recessive model GWAS results.

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 17/08/2026

A new review highlights GP2’s progress in genetic discovery and its work to build research capacity worldwide through training, mentorship, hackathons, and support for early-career investigators. 🔗 Read the #publication: bit.ly/4g4tTeK

The Global Parkinson's Genetics Program (GP2): Advancing genetic discovery and capacity building worldwide.

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 17/08/2026

Drawing on the BLAAC PD study, researchers shared inclusive recruitment strategies centered on equitable research practices, community partnerships, culturally resonant materials, and locally tailored methods. 🔗 Read the #publication: bit.ly/4q6JBKI

Annotated example of BLAAC PD flyer explaining inclusive design considerations.

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 17/08/2026

GP2 researchers created a comprehensive catalog of potentially disease-causing coding and splicing variants in African and African-admixed populations, expanding insight into population-specific genetic factors. 🔗 Read the #publication: bit.ly/3TTy0mj

Large-scale genetic characterization of Parkinson’s disease in the African and African admixed populations.

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 17/08/2026

In a study of Parkinson’s genetics in Taiwan, researchers identified shared and East Asian-enriched risk factors. Incorporating population-relevant variants also improved polygenic risk score performance. 🔗 Read the #preprint: bit.ly/4wqQNTI

Genome-wide association results for Parkinson’s disease in the Taiwanese cohort.

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 17/08/2026

GP2 researchers conducted the first large-scale, multi-ancestry study of genome-wide homozygosity in Parkinson’s, identifying ancestry-specific patterns linked to disease risk and age at onset. 🔗 Read the #publication: bit.ly/4wjoqGI

Genome-Wide Assessment Reveals Ancestral Differences in Homozygosity Patterns Potentially Linked to Parkinson's Disease Etiology.

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 13/08/2026

We’re excited to welcome William Mobley, MD, PhD, from the University of California, San Diego, as the August LRRK2 Central #webinar speaker. 👇 Reserve your spot using the link below. 📅 August 20, 2026 ⏰ 1:00 PM ET RSVP: bit.ly/45aJqoa

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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 12/08/2026

CRN Team Wichmann found that progressive dopamine loss disrupts motor-cortex activity and movement encoding as skilled movement declines, revealing how cortical dysfunction emerges during Parkinsonism. 🔗 Read the #preprint: bit.ly/4wJKD1S

Skilled movement deteriorates during progressive loss of midbrain DA neurons (Chehade et al., 2026).

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