Reposted by Ariana CostasProf Jenny Rohn @jennyrohn.bsky.social · 02/10/2025People spend loads on #UTI preventions that aren’t truly effective, like D-mannose. £19.99 only buys you a 2-week course. The rest of the products on display were similarly expensive and unlikely to do much. We need better therapies! (See Alt text for source of negative D-mannose RCT) #UTISky 071
Ariana Costas @arianacostas.bsky.social · 05/09/2025🚨New paper 🚨 #UTIsky #UTI #UPEC dx.plos.org/10.1371/jour...dx.plos.orgUropathogenic Escherichia coli proliferate as a coccoid morphotype inside human host cellsAlthough typically rod-shaped, uropathogenic E. coli divide and proliferate as round coccoid cells during intracellular infection. This study shows that accelerated division via FtsZ constriction driv... 012
Reposted by Ariana CostasProfessor Lesley Hoyles @bugsinyourguts.bsky.social · 25/04/2025Really nice paper. #Microsky #UTIsky www.nature.com/articles/s41...nature.comMetabolomics strategy for diagnosing urinary tract infections - Nature CommunicationsMicrobial catabolites in urine provide a rapid method for detecting urinary tract infections (UTIs). Here, the authors describe an LC-MS metabolomics approach for detecting two catabolites collectivel... 164
Reposted by Ariana CostasNCCR AntiResist @nccr-antiresist.bsky.social · 27/03/2025Congratulations to @carlosebflores.bsky.social on his latest publication with @jennyrohn.bsky.social, "Bacterial adhesion strategies and countermeasures in urinary tract infection" in @naturemicrobiol.bsky.social Read it here 👉 www.nature.com/articles/s41...nature.comBacterial adhesion strategies and countermeasures in urinary tract infection - Nature MicrobiologyThis Review discusses adhesion strategies of bacterial pathogens causing urinary tract infections, and outlines host responses and recent advances in therapeutic strategies targeting bacterial adhesio... 2123
Ariana Costas @arianacostas.bsky.social · 27/03/2025A new review for some Thursday morning reading! This paper details the elements needed to develop relevant physiologic models of the bladder and discusses current technology. Very grateful to have been a part of this review! Happy reading, everyone! #UTIsky #UTI www.nature.com/articles/s41...nature.comA bladder blueprint to build better models for understanding homeostasis and disease - Nature Reviews UrologyIn this Review, the authors present the development, structure and microenvironment, and defence mechanisms of the bladder, which together create a blueprint that can be used to optimize current model... 021
Reposted by Ariana CostasBill Söderström @bill-lab.bsky.social · 23/12/2024Need a break from the Christmas food? Check out the latest supercool ex-vivo UTI model from the ingersoll lab @immunobladder.bsky.social www.biorxiv.org/content/10.1...biorxiv.orgA simple ex vivo bladder infection model permits study of host-pathogen interactions in UTIUrinary tract infections (UTI) are one of the most common infections, worldwide. To understand mechanisms of UTI pathogenesis and find new treatments, researchers often use animal models, such as mice... 021
Reposted by Ariana CostasAustralian Institute for Microbiology and Infection @aimi-uts.bsky.social · 06/12/2024Four out of five prizes won🎖️ by AIMI students at the UTS Faculty of Science Transdisciplinary ECR Retreat Congratulations to: Lachy (best talk) Liam (runner up talk) Sophia (people’s choice talk) @arianacostas.bsky.social (best poster) 084
Reposted by Ariana CostasRebecca J Hall @drrebeccajhall.bsky.social · 27/11/2024🚨 New preprint 🚨 With two excellent students Shalini Choudhary and Jacob Smith, we started looking at how the metabolic microenvironment of the urinary tract might affect uropathogenic E. coli evolution and response to antibiotics. www.biorxiv.org/content/10.1...biorxiv.orgGlucose alters the evolutionary response to gentamicin in uropathogenic Escherichia coliUrinary tract infections (UTI) are a major health and economic concern. Uropathogenic Escherichia coli (UPEC) are the leading cause of UTI, and antibiotic resistant UPEC are increasingly common. The m... 15324
Reposted by Ariana CostasHannah Brown 🧂🦠🔬 @hannjbrown.bsky.social · 23/11/2024🚨 New paper alert! 🚨 MinD is famously known for positioning FtsZ at mid-cell in bacteria In our study, myself and @iduggin.bsky.social found that MinD homologues in Haloferax volcanii influence the localisation of CetZ1, a homologue of FtsZ and tubulin #Archaeasky #Microskyurl.au.m.mimecastprotect.comFrontiers | MinD proteins regulate CetZ1 localization in Haloferax volcanii 14614
Reposted by Ariana CostasKaty Patras @katypatras.bsky.social · 25/10/2024Why is preterm birth risk doubled with maternal UTI? It depends on the immune response. We found distinct immune signatures in a UTI-associated preterm birth mouse model. In a human cohort from @AShea_Lab, urine cytokine levels could predict preterm birth. www.biorxiv.org/content/10.1...biorxiv.orgDistinct maternofetal immune signatures delineate preterm birth onset following urinary tract infectionPreterm birth is the leading cause of infant mortality resulting in over one million neonatal deaths annually. Maternal urinary tract infection (UTI) during pregnancy increases risk for preterm birth;... 0104
Reposted by Ariana CostasAustralian Institute for Microbiology and Infection @aimi-uts.bsky.social · 20/11/2024Interested in following our researchers and their work? Find them in our starter pack of AIMI researchers! go.bsky.app/QYFfTtT #microsky #microbiology 044
Reposted by Ariana CostasAustralian Institute for Microbiology and Infection @aimi-uts.bsky.social · 20/11/2024Our mission is to decipher interlinked human, animal, and environmental problems in microbiology and disease We investigate how microbes grow, live, adapt, and survive, with a focus on antibiotic resistance, infectious diseases, vaccine development, and biosecurity 052
Reposted by Ariana CostasJAMS Sydney @jamsorgsyd.bsky.social · 20/11/2024JAMS Sydney has made its way to Bluesky! ✨ Help us connect JAMSters as they make their way over so let us know if you'd like to be added! 🦠 go.bsky.app/B1uUprK 144
Ariana Costas @arianacostas.bsky.social · 19/11/2024It is World Antimicrobial Resistance Awareness week and the CSIRO have some very funny memes (This ABBA one is my favourite) www.csiro.au/en/news/all/... 021
Reposted by Ariana CostasBill Söderström @bill-lab.bsky.social · 17/11/2024If you are in Sydney don’t miss the AMR day this Thursday: www.theasm.org.au/conferences-...theasm.org.auAntimicrobial Resistance Symposium 2024 — Australian Society for MicrobiologyA collaboration between the Australian Institute for Microbiology and Infection (AIMI) at UTS and the Australian Society for Microbiology NSW-ACT Branch. Join us for a one-day symposium dedicated to ... 043