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Valentin Rodionov

@arbitraryeffect.bsky.social
2K followers 1.3K following 729 posts

Chemist. Neurodivergent. Orcophobe. Hand-tool woodworker. Faculty @ CWRU Macro. Founder @intellicat.ai

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Valentin Rodionov @arbitraryeffect.bsky.social · 27/08/2026
I see the context of the post as, "replicability crisis is an overhyped right wing talking point". Which bad actors used to destroy whole fields. I agree that this is what happened (i.e. field destruction). But to claim that all is hunky dory on the science side is incorrect.
What do you want me to do?  LEAVE?  Then they'll keep being wrong!
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Valentin Rodionov @arbitraryeffect.bsky.social · 27/08/2026
And here are the global publication numbers for all sciences, aggregated from OpenAlex. ~1.7M papers in 2000, 8.4M in 2025. There are not 5x more scientists now compared to 2000. Much of that output is not credible. It is published to exist. Science is in crisis. And bad people will use it.
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Valentin Rodionov @arbitraryeffect.bsky.social · 27/08/2026
Wow - Macchiarini has a Substack! 🤡 Also, these two names are not, in fact, inside the same argument.
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Valentin Rodionov @arbitraryeffect.bsky.social · 18/07/2026
The only thing he is "on to" here is offloading critical reading of cited papers on to an LLM. Checking links is not the same as proper, critical citation. Also, an LLM is not a search engine (even if it is integrated with one).
An image of a high priest.
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Valentin Rodionov @arbitraryeffect.bsky.social · 18/07/2026
The problem is the phrase "checked the links." Checking a link tells you a URL resolves. It does not tell you the paper behind it says what you claim. He trusted the model on the content, did not read the sources himself, and announced it in public.
Captain Picard doing a facepalm maneuver.
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Valentin Rodionov @arbitraryeffect.bsky.social · 18/07/2026
Screenshotted for the record, in case it vanishes. The Editor-in-Chief of Science, explaining how the citations in his latest piece were checked. Short thread. 🧵
Screenshot of Holden Thorp's skeet that says:

Hi, this is Holden emerging from my Bluesky hiatus to tell everyone that when checking the links in the piece, I used ChatGPT as my search engine (does anyone use Google anymore?). The piece was written by me and edited by humans. So all the links were checked by me and again by our copyeditors.
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Valentin Rodionov @arbitraryeffect.bsky.social · 05/07/2026
Sidney is wishing you a happy caturday!
A tuxedo cat on a carpet, looking at you.
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Valentin Rodionov @arbitraryeffect.bsky.social · 26/05/2026
Case in point: γ-graphyne, an acetylenic 2D carbon allotrope. Xiaoli Cui's group at Fudan claims to make it by ball-milling hexabromobenzene (or just benzene!) with calcium carbide. Their 2018 Carbon paper alone has 319 citations. The claimed chemistry is ridiculous and impossible.
Purported synthesis of graphyne from hexabromobenzene (or benzene!). Of all the things that did not happen, this one did not happen the most.
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Valentin Rodionov @arbitraryeffect.bsky.social · 31/03/2026
Here is what the Russians actually published in 2013 (doi: 10.30906/0023-1134-2013-47-8-41-44). DBU is specifically used in the VI --> VII ring closing step. The advantage of using DBU there is that VII is clean enough to crystallize. No annoying column chromatography!
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Valentin Rodionov @arbitraryeffect.bsky.social · 31/03/2026
@theins.press article specifically quotes their source as claiming DBU being the "most important ... reliable marker" for the synthesis of epibatidine. That is simply incorrect, and the quote from their source (attached here) is something of a word salad. I doubt they were a real chemist.
“All of these substances can be called marker reagents, but it is precisely 1,8-diazabicyclo[5.4.0]undec-7-ene that is the most important among them. Someone might even call it a precursor, but that would be incorrect, since a precursor is the base to which another substance is added to obtain the target compound, so in this case we are dealing with that second substance. Among all the other reagents, which may include ordinary solvents, this is the most reliable marker.”
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Valentin Rodionov @arbitraryeffect.bsky.social · 31/03/2026
DBU is easily accessible (standard industrial synthesis involves caprolactam and acrylonitrile). It is one of the most standard bases used in organic synthesis, and is also used as a curing agent for some epoxy resins. It is very inexpensive and universally available. Russia likely makes its own.
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Valentin Rodionov @arbitraryeffect.bsky.social · 31/03/2026
This brings me back to @theins.press reporting. Quoting the article: "...the key component for creating the bicyclic compound: 1,8-diazabicyclo[5.4.0]undec-7-ene..." The name sounds complicated, so that stuff must be rare and unique. Except it is not. It is just DBU - one of the commonest reagents.
1,8-Diazabicyclo[5.4.0]undec-7-ene also known affectionately as DBU. Possibly one of the most common organic bases.
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Valentin Rodionov @arbitraryeffect.bsky.social · 31/03/2026
Now, 6-chloropyridine-3-carboxaldehyde is not particularly hard to make, and not especially expensive. Current Thermo Fisher price is $127 per gram. Quirky building blocks like this would rarely if ever show up in importer databases. It is a small-volume, obscure research chemical.
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Valentin Rodionov @arbitraryeffect.bsky.social · 31/03/2026
The second thing that is apparent is that all the compounds on the list, with one critical exception, are generic, and not related specifically to the structure or synthesis of epibatidine. The one exception? 6-chloropyridine-3-carbaldehyde. If you think it looks like a part of epibatidine - yes!
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Valentin Rodionov @arbitraryeffect.bsky.social · 31/03/2026
@theins.press article lists compounds involved in the published synthesis of epibatidine, and the number of RU importers. So far, so good... or not. The first thing to notice is that 3-buten-2-one is methyl vinyl ketone (MVK), which Russia certainly makes on multi-ton scale, and likely imports too.
A table with compounds listed in the published synthesis of epibatidine. The key molecules of interest are 3-buten-2-one (aka methyl vinyl ketone), and 6-chloropyridine-3-carbaldehyde, as the only molecule structurally related to the target alkaloid.Skeletal structure of epibatidine.
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Valentin Rodionov @arbitraryeffect.bsky.social · 28/03/2026
This wonderful letter is also very likely generated by an LLM. Even without running it through the detector, the slop is easy to see. So classy. I feel bad for those on the receiving end.
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Valentin Rodionov @arbitraryeffect.bsky.social · 04/03/2026
This you? For the interested readers: first image failing vertical line test is a crop from doi.org/10.1016/j.im... Second is from a PubPeer post related to doi.org/10.1038/s414... The 2024 "NanoImpact" paper already cited ~24 times, Nat Comm ~255 times. Good times.
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Valentin Rodionov @arbitraryeffect.bsky.social · 26/02/2026
So many things wrong with this post. 1. In the 90s RU, Communists were the *conservatives*. There were ~14 parties in the '93 Congress, with a slight conservative majority 2. The crisis was not "oligarchs vs people". It was infighting in the power structure, with Yeltsin arguably the "better" guy.
Russian Congressional factions of Spring 1993. Conservatives (Communists, Agrarian Union, + allied factions) hold a slight majority.
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Valentin Rodionov @arbitraryeffect.bsky.social · 06/02/2026
1. You used "Democrat" precisely because it is relevant. 2. We have a 2-party system. The right-wing party devolved into Nazis. Your (in)actions helped Nazis. The dismantling of USAID and ongoing genocides in Gaza and Ukraine are on you. 3. Yes, Greens support genocide (see attached). Any comments?
Jull Stein and fellow travelers having a friendly dinner with Putin.
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Valentin Rodionov @arbitraryeffect.bsky.social · 30/01/2026
It's a shame he is a Putin supporter. ocdn.eu/sport-images...
Coelho and Putin enjoying a friendly chat.
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Valentin Rodionov @arbitraryeffect.bsky.social · 15/12/2025
Around 2016–17, creeping Apple hardware enshittification pushed me to Windows. By then Windows had WSL2 providing a proper bash shell, and, crucially, Photoshop, Illustrator, ChemDraw, and MS Office, all well integrated.
An image of a MacBook Pro keyboard Touch Bar, which replaced the function keys and even the Esc button.
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Valentin Rodionov @arbitraryeffect.bsky.social · 15/12/2025
Perspective matters: I’m far from a Linux/Unix noob. I started on IRIX 6.5 on an SGI Octane, an Red Hat 7.x on my trusty PII-450 around 2000. SGI's Indigo Magic was polished and Just Worked™; early Linux… less so. 🧓
This is an image of a SGI Octane workstation from ~1999. It has green skins and the original "cube" Silicon Graphics logo.A screenshot of the IRIX Indigo Magic desktop environment. The elements present are: Toolchest, which works similarly to the Start Menu; Icon Catalog; and the Desktop Overview which allows quick navigation.
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Valentin Rodionov @arbitraryeffect.bsky.social · 03/12/2025
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Valentin Rodionov @arbitraryeffect.bsky.social · 02/12/2025
You’re in a desert walking along when all of the sudden you look down, and you see a tortoise. You reach down, you flip the tortoise over on its back. The tortoise lays on its back, beating its legs trying to turn itself over, but it can’t, not without your help. But you’re not helping. Why is that?
A GIF of the Voight-Kampff test from the original Blade Runner movie.
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Valentin Rodionov @arbitraryeffect.bsky.social · 08/10/2025
Here are a few more doi's from the same journal, some already flagged on PubPeer, some not, all 💯 fabricated with hand-drawn or nonsensical spectra and PXRDs, and citation padding. 10.1002/app.57648 10.1002/app.56053 10.1002/app.56837 (the "IR spectrum" is Fig. S2, 10.1002/app.57648).
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Valentin Rodionov @arbitraryeffect.bsky.social · 08/10/2025
Or how do you make peace with the main scheme of the paper? While the "initiator" is KMnO4/oxalic acid, PAN chains magically grow directly from chitosan. It must be magic, because this cannot be accomplished with chemistry. This passed 🍐review, and has been on display in this journal for 15 years.
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Valentin Rodionov @arbitraryeffect.bsky.social · 08/10/2025
"We have asked the authors to provide a detailed explanation and supporting data to address the concerns. The authors were able to do so to our satisfaction, hence we consider the matter resolved. " How do you "resolve" pixel-identical stretches of background in two NMR spectra?
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Valentin Rodionov @arbitraryeffect.bsky.social · 08/10/2025
Re-posting Dr. Wittmers' thread, with a some supporting info. Fabian flagged a paper in J. Appl. Polym. Sci for region duplication in PXRD (see pubpeer.com/publications... ), and reported it to Wiley. I have found additional duplications and crazy chemistry. Wiley's response? All 💯 👍 #ChemSky
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Valentin Rodionov @arbitraryeffect.bsky.social · 24/09/2025
De-extincted species be like (image attribution: halloweencostumes.com)
An image of a preschooler in a dinosaur costume.
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Valentin Rodionov @arbitraryeffect.bsky.social · 26/08/2025
Right here (see the screenshot).
Screenshot of a both-side post
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Valentin Rodionov @arbitraryeffect.bsky.social · 22/06/2025
Sydney the woodworker cat. Happy #Caturday ! In case you were wondering: the plane is a Type 4 No. 5 Stanley (1874-1884). Probably the oldest I have ever restored.
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Valentin Rodionov @arbitraryeffect.bsky.social · 11/06/2025
And here are some cool pictures! The periodicity of the "bumps" on the lateral force image corresponds to the crystallographic planes bisecting aromatic rings. And the triple bonds are very visible in Raman, even in films ~20 atoms thick (or thin?).
Scanning probe microscopy of a γ-graphyne film synthesized using water-soluble Pd(TPPTS)3. (A) Lateral deflection map of a re-gion of the film. (B) Periodicity of the low-pass filtered lateral deflection maps for the HOPG reference and γ-graphyne. Colored bars mark the confidence intervals for lattice constants.Raman spectra of γ-graphyne films synthesized using water-soluble Pd(TPPTS)3. The spectra were measured using an excitation wavelength of 442 nm. The prominent peak at 2197 cm-1 corresponds to acetylenic bonds.
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Valentin Rodionov @arbitraryeffect.bsky.social · 11/06/2025
We synthesized few-layer films of γ-graphyne (the ≡ bond carbon allotrope) at a liquid/liquid interface. It's a much cleaner synthesis than our original batch method - and the stacking of the layers is orderly! Coming soon to a 🍐-reviewed journal. Preprint 🠟🠟🠟 #ChemSky doi.org/10.26434/che...
Interfacial synthesis of γ-graphyne. (A) Batch synthesis of Br-edge γ-graphyne (GY-Br) through 2D polymerization of TBTEB monomer. (B) Interfacial synthesis of γ-graphyne using a lipophilic Pd(PPh3)4 pre-catalyst. Both the catalyst and TBTEB monomer are in organic solvent. (C) Interfacial synthesis of γ-graphyne using a water-soluble Pd(TPPTS)3 pre-catalyst. The TBTEB monomer is in the organic solvent, while the catalyst is in water.
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Valentin Rodionov @arbitraryeffect.bsky.social · 04/05/2025
It's pretty clear the model plagiarized this old Soviet anti-alcohol poster. It's kind of appropriately hilarious given who is depicted.
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Valentin Rodionov @arbitraryeffect.bsky.social · 02/05/2025
So I just opened my fridge, and discovered a very interesting product: poppi prebiotic soda! Pre/probiotic mix-up is one of my pet peeves. This one gives some definite Engineer vibes. The soda actually tastes pretty good. #ChemSky 🧪
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Valentin Rodionov @arbitraryeffect.bsky.social · 18/04/2025
Found it! It is hiding in the "Save as Image". What threw me off was the .pdf option in "Save As". The resulting .SVG plays better with InkScape than any of my previous attempts. Progress!
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Valentin Rodionov @arbitraryeffect.bsky.social · 18/04/2025
Marvin cannot export SVG (or the option is cleverly hidden?). Also, structures copied as .PDF and saved as .PDF open differently by InkScape. Copying completely obliterates any formatting.
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Valentin Rodionov @arbitraryeffect.bsky.social · 18/04/2025
I am sure it is possible to get things done with IS, sort of. So far I am extremely unimpressed. It does not import well from most chemical drawing software. The UI is a disaster. The inspectors do not follow selection type, there is no "select same" for fonts, etc. But I can rotate artboards!
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Valentin Rodionov @arbitraryeffect.bsky.social · 06/04/2025
Also daffodils and hyacinths (though these are not as bad as lilies). In daffodils, the offending alkaloid is lycorine. www.aspca.org/pet-care/ani... www.aspca.org/pet-care/ani...
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Valentin Rodionov @arbitraryeffect.bsky.social · 02/04/2025
Here is the syllabus (on a side note, I was surprised you cannot post a .PDF to BlueSky).
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Valentin Rodionov @arbitraryeffect.bsky.social · 02/04/2025
Here is DeepSeek "thinking". It is very sure of itself. By the way, the results are generally better than ChatGPT or Gemini - but it's still not anywhere close to genuine reasoning.
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Valentin Rodionov @arbitraryeffect.bsky.social · 26/03/2025
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Valentin Rodionov @arbitraryeffect.bsky.social · 23/03/2025
On-the-spot guidance. en.m.wikipedia.org/wiki/On-the-...
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Valentin Rodionov @arbitraryeffect.bsky.social · 17/03/2025
And all to power the bullshit machines. Even if these constructs could be made intelligent, burning down fossil fuels to power them would be unconscionable. Since these are just LLMs, this is also incredibly stupid. thebullshitmachines.com
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Valentin Rodionov @arbitraryeffect.bsky.social · 19/02/2025
Jut looked it up. Yes, it is a Gemini LLM with bolted-on bits for web search and AlphaGo-like self-play (also done with LLMs). Taken in isolation, their block diagram could be used as an example of how *not* to do science. And LLMs fundamentally cannot reason. I just wish the LLM bubble pops soon.
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Valentin Rodionov @arbitraryeffect.bsky.social · 18/02/2025
I want to tap into the collective intelligence of ChemSky and learn a bit about EXAFS. I just came across the EXAFS spectra and fitting parameters attached here. Do these look broadly reasonable? If not, why? The source paper will for now remain nameless, but it has fake Raman data. #ChemSky
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Valentin Rodionov @arbitraryeffect.bsky.social · 13/02/2025
This is probably the funniest/fakest PXRD pattern I have ever seen (and I go through a lot of papermill products). Found in US patent application US 2023/0088084 A1. Brought to you by the same fine people who "discovered" "holey graphyne". www.chemistryworld.com/opinion/hole... #ChemSky
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Valentin Rodionov @arbitraryeffect.bsky.social · 27/01/2025
Deepseek is better than ChatGPT 4o on my "brick/feathers" test. It gave a correct answer 4 out of 5 times. ChatGPT answered wrong 4 out of 5 times, and Gemini failed hilariously and spectacularly 100% of the time.
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Valentin Rodionov @arbitraryeffect.bsky.social · 27/01/2025
The current incarnation of imitative "AI" is as useful as a calculator that is wrong 35% of the time. I just asked Gemini and ChatGPT what is heavier, 1 kg of feathers or 2 lb of bricks. Both models said the bricks are heavier 😂
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Valentin Rodionov @arbitraryeffect.bsky.social · 23/01/2025
It's not the only "dark matter alkyne" paper from the same source. More are already on PubPeer, with the authors trying to defend the indefensible. And yes, the attached "reaction scheme" was published in an Elsevier journal in 2022. It's still there. pubpeer.com/publications...
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