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Anu Sharma

@anu-sharma.bsky.social
477 followers 274 following 17 posts

Postdoc in the Meirelles lab @Mass Gen/Harvard. Associate Scientist @Broad Institute. Studying bacterial life beyond the petri dish.

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Reposted by Anu Sharma
Lucas A. Meirelles @la-meirelles.bsky.social · 23/06/2026
Our newest preprint is out! 🧫 Can pathogens affect epithelial regeneration? And if so, what are the consequences for the tissue and pathogen physiology? We used pyocyanin, a Pseudomonas aeruginosa metabolite, to start addressing this. www.biorxiv.org/content/10.64898/2026.06.15.732350v1 🧵
biorxiv.org
Pyocyanin disrupts airway regeneration to favor chronic Pseudomonas aeruginosa infection
During chronic infections, host tissues undergo repeated cycles of injury and repair while being exposed to bacterial products. Although many virulence factors trigger immune responses, whether bacter...
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Itai Yanai @itaiyanai.bsky.social · 15/08/2025
Why would anyone want to be a scientist? There are the pleasures of: 1. Having the initial idea or insight, 2. Watching the idea develop into new experiments or a new model, and 3. Telling others. Martin A. Schwartz Check out also his Night Science podcast episode: podcasts.apple.com/us/podcast/7...
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Jolene Ramsey @jrrmicro.bsky.social · 07/08/2025
@anu-sharma.bsky.social want a twitch? lose itch to use LB, go with flow and your cells may grow #sciku 🧪🧬🔬🧫🦠 #Phages2025 doi.org/10.1016/j.cu...
doi.org
Redirecting
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Amelia Randich @ameliarandich.bsky.social · 07/08/2025
@anu-sharma.bsky.social: flow increases H2O2 effectiveness against #pseudomonas 50-fold, combining the two blocks motility and growth #phages2025 🦠 www.cell.com/current-biol...
cell.com
Combining multiple stressors blocks bacterial migration and growth
Here, Sharma et al. use microfluidics to simultaneously provide a physical stressor (shear flow) and a chemical stressor (H2O2) to the human pathogen Pseudomonas aeruginosa. The replenishing power of ...
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Lars Dietrich @laahrs.bsky.social · 25/06/2025
www.quantamagazine.org/how-a-biofil...
quantamagazine.org
How a Biofilm’s Strange Shape Emerges From Cellular Geometry | Quanta Magazine
Micro decisions can have macro consequences. A soft matter physicist reveals how interactions within simple cellular collectives can lead to emergent physical traits.
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STCmicrobeblog @stcmicrobeblog.bsky.social · 09/06/2025
(bacterial) cell divisionists take note, unbedingt 👇 #MicroSky
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John Helmann @johnhelmann.bsky.social · 16/04/2025
In B. subtilis, TerC proteins function in Mn export to support the metalation of exoenzymes. MeeY is also required (directly or indirectly) for production of surfactin, a lipopeptide required for swarming motility! (collab. with Dan Kearns' lab @IU). #MicroSky journals.asm.org/doi/10.1128/...
journals.asm.org
The TerC family metal chaperone MeeY enables surfactin export in Bacillus subtilis | Journal of Bacteriology
Bacillus subtilis produces surfactin, a powerful detergent-like compound that functions in intercellular communication, surface motility, and as a broad-spectrum antimicrobial agent. Production of surfactin, a cyclic lipopeptide, depends on a non-...
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Anu Sharma @anu-sharma.bsky.social · 18/03/2025
Read this to find out how fluid flow influences antimicrobial delivery! 🧪 Glad to be a part of this work. Congratulations @ashuppara.bsky.social!
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Yves Brun lab @brunlabcaulo.bsky.social · 19/02/2025
1/10 🧵 Injecting some science in your feed: Happy to share another chapter in our investigation of bacterial surface sensing. We describe the role of CpaL, a minor pilin-like protein, a key player in surface sensing and adhesion in Caulobacter crescentus. #microsky www.biorxiv.org/content/10.1...
biorxiv.org
Stimulation of the Caulobacter crescentus surface sensing pathway by deletion of a specialized minor pilin-like gene
Bacteria colonize surfaces through complex mechanisms of surface sensing. Pili are dynamic bacterial appendages that play an important role in this process. In Caulobacter crescentus , tension on retr...
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Gilberto Padron @flowbert.bsky.social · 24/12/2024
How do bacteria experience nutrient stress in nature? In our new preprint, we study how cells respond to nutrient limitation under flow. We find that in flow, cells can grow on concentrations of glucose 1,000 times lower than in batch cell culture. (1/5) #microsky www.biorxiv.org/content/10.1...
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School of Molecular & Cellular Biology at Illinois (U. of I.) @mcbillinois.bsky.social · 12/12/2024
New research from the lab of Joe Sanfilippo demonstrates that the amount of hydrogen peroxide required to inhibit bacterial growth is 50x less than previously thought, at amounts naturally present in the human body. go.mcb.illinois.edu/bacteria
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Leibniz Institute DSMZ @leibniz-dsmz.bsky.social · 05/12/2024
To honour Abigail A. Salyers (1942-2013), who is considered as the mother of microbiome research, DSMZ researchers named the strain Streptomyces salyersiae (DSM 41770) after her. #WomenInScience #antibiotics #antibioticresistance #microbiome #microbiology
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Michael Baym @baym.lol · 21/11/2024
The first review article from my lab, helmed by @celiasouque.bsky.social, "From Petri Dishes to Patients to Populations: Scales and Evolutionary Mechanisms Driving Antibiotic Resistance" is now online and open access at Annual Reviews Microbiology: www.annualreviews.org/content/jour...
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Gilberto Padron @flowbert.bsky.social · 19/11/2024
So excited to see this in press! Congratulations to @anu-sharma.bsky.social for her fantastic work and first published first author paper. Check it out!!!
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Anu Sharma @anu-sharma.bsky.social · 19/11/2024
Do you feel stressed? Is it one thing or a combination? Turns out bacteria can’t handle stress either! Excited to share my first first author paper out now in @currentbiology.bsky.social! Combining multiple stressors blocks bacterial migration and growth! www.cell.com/current-biol...
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Reposted by Anu Sharma
Anupama Khare @anukharelab.bsky.social · 18/11/2024
Check out this new review from our lab led by postdoc Pavan Silva! We explore the varied mechanisms by which gene amplifications lead to antibiotic resistance. www.nature.com/articles/s44...
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