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Anastasia (Stacy) Henry

@anastasiahenry.bsky.social
51 followers 40 following 12 posts

Senior Director and Staff Scientist at Denali Therapeutics. My lab is focused on understanding how lysosomal function is perturbed in Parkinson's disease and LSDs.

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Anastasia (Stacy) Henry @anastasiahenry.bsky.social · 09/10/2026
I’m looking to recruit a postdoc to join our Parkinson's and Rare Disease biology team at Denali! Come help us explore how PD-linked variants regulate lysosomal function across CNS cell types as part of our larger ASAP team effort. Apply: dnli.wd1.myworkdayjobs.com/Discovery/jo...
dnli.wd1.myworkdayjobs.com
Postdoctoral Fellow, PD and Rare Disease
Denali Therapeutics Inc. is a biotechnology company pioneering a new class of biotherapeutics designed to cross the blood-brain barrier (BBB) using its proprietary TransportVehicle™ platform. With the...
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Anastasia (Stacy) Henry @anastasiahenry.bsky.social · 12/09/2026
We are looking to recruit a computational biologist to join Denali's Discovery team. This is a great opportunity to make a direct impact on our early-stage portfolio! dnli.wd1.myworkdayjobs.com/Discovery/jo...
dnli.wd1.myworkdayjobs.com
Senior Scientist, Computational Biology
We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients. This role helps define the direction of computational biology efforts a...
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Anastasia (Stacy) Henry @anastasiahenry.bsky.social · 06/05/2026
Excited to be elected to the ASCB Council for 2027! I'm looking forward to working together with the rest of the team and helping to bring some industry perspective to ASCB's initiatives. www.ascb.org/society-news...
ascb.org
Rebecca Heald Elected 2028 ASCB President - ASCB
ASCB members have elected Rebecca Heald, Professor of Cell and Developmental Biology at the University of California, Berkeley, to serve as the Society’s President in 2028. Heald is an internationally...
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Anastasia (Stacy) Henry @anastasiahenry.bsky.social · 01/05/2026
Excited to share that our team is joining the ASAP Collaborative Research Network! We look forward to collaborating with scientists globally to catalyze breakthroughs in Parkinson’s & accelerate discoveries that lead to new treatments. Explore more: asapcrn.org #ParkinsonsDisease
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Reposted by Anastasia (Stacy) Henry
Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 28/04/2026
📢 Unraveling Parkinson’s. Advancing Precision Medicine. New CRN grants in partnership with The Michael J. Fox Foundation for Parkinson’s Research bring together 32 global teams to map the biology of #ParkinsonsDisease and build tools to accelerate discovery. 🔗 Learn more: bit.ly/4ugkfes
Graphic with a light purple gradient background featuring the headline: “Unraveling Parkinson’s. Advancing Precision Medicine.” Subhead reads: “Mapping the biological blueprint of Parkinson’s disease and building global research resources.” Along the bottom are logos for ASAP (Aligning Science Across Parkinson’s), the Collaborative Research Network (CRN), and The Michael J. Fox Foundation for Parkinson’s Research.
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Anastasia (Stacy) Henry @anastasiahenry.bsky.social · 25/03/2026
investors.denalitherapeutics.com/news-release...
investors.denalitherapeutics.com
Denali Therapeutics Announces U.S. FDA Approval of AVLAYAH™ (tividenofusp alfa-eknm) for Treatment of Hunter Syndrome (MPS II) | Denali Therapeutics
The Investor Relations website contains information about Denali Therapeutics's business for stockholders, potential investors, and financial analysts.
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Reposted by Anastasia (Stacy) Henry
Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 12/11/2025
AMP® PDRD is accepting applications from clinical investigators with study cohorts in #Parkinsons or related disorders. Selected projects will receive fully funded biomarker analyses, at no cost to investigators 🧪 🧠 Apply by November 21, 2025 🔗 See the RFA: bit.ly/49yx7oW
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Anastasia (Stacy) Henry @anastasiahenry.bsky.social · 17/10/2025
Exciting opportunity for clinical researchers in Parkinson’s disease and related disorders: The Accelerating Medicines Partnership in Parkinson’s Disease and Related Disorders (AMP PDRD) is seeking applications for fully-funded biomarker analyses. Learn more here: lnkd.in/dwFYNy6u
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Anastasia (Stacy) Henry @anastasiahenry.bsky.social · 02/09/2025
New preprint alert! We show that the common GBA1 E326K variant leads to impaired lysosomal delivery of GCase and defects in PD-relevant pathways. Structures of E326K alone and with LIMP2 reveal mechanistic insight. Big thanks to the Vocadlo and Cookson labs! 👉 www.biorxiv.org/content/10.1...
biorxiv.org
A Common PD-Risk GBA1 Variant Disrupts LIMP2 Interaction, Impairs Glucocerebrosidase Function, and Drives Lysosomal and Mitochondrial Dysfunction
Variants in GBA1 cause Gaucher disease (GD), a lysosomal storage disorder, and represent the most common genetic risk factor for Parkinson's disease (PD). While some GBA1 variants are associated with ...
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Anastasia (Stacy) Henry @anastasiahenry.bsky.social · 07/08/2025
Our new study in Molecular Neurodegeneration shows that LRRK2 kinase activity modulates lysosomal glycosphingolipid and BMP homeostasis. We also report how LRRK2 inhibition alters these biomarkers in LRRK2-PD patients, highlighting their translational potential. Read more: rdcu.be/ezDU1
rdcu.be
LRRK2 kinase activity regulates Parkinson’s disease-relevant lipids at the lysosome
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Anastasia (Stacy) Henry @anastasiahenry.bsky.social · 16/01/2025
🚨New job post alert 🚨 We are looking to recruit a talented in vivo scientist to support our growing Parkinson's disease portfolio. Please reach out if you are interested in learning more! www.denalitherapeutics.com/job?id=0844a...
denalitherapeutics.com
Job
Denali Therapeutics is dedicated to defeating neurodegenerative diseases through rigorous therapeutic discovery and development.
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Anastasia (Stacy) Henry @anastasiahenry.bsky.social · 05/12/2024
Excited to share that dosing has begun in the Denali Phase 2a "BEACON" study of the investigational therapeutic BIIB122 in Parkinson's disease patients that carry a variant in LRRK2! investors.denalitherapeutics.com/news-release...
investors.denalitherapeutics.com
Denali Therapeutics Announces First Participant Dosed in Phase 2a Study of LRRK2 Inhibitor, BIIB122, in LRRK2-Associated Parkinson’s Disease | Denali Therapeutics
The Investor Relations website contains information about Denali Therapeutics's business for stockholders, potential investors, and financial analysts.
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Anastasia (Stacy) Henry @anastasiahenry.bsky.social · 25/11/2024
Interested in doing an internship in industry exploring the mechanisms of lysosomal dysfunction associated with PD? Here's a great opportunity to work with an outstanding scientist in my team! dnli.wd1.myworkdayjobs.com/Internships/...
dnli.wd1.myworkdayjobs.com
Intern, Pathway Biology
Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative di...
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Anastasia (Stacy) Henry @anastasiahenry.bsky.social · 12/11/2024
We had a fantastic time collaborating with Ta-Chiang Liu and his team to assess the role of LRRK2 activity in Paneth cell dysfunction linked to Crohn's disease. Our paper is now out in Science Immunology! www.science.org/doi/10.1126/...
science.org
Macrophage LRRK2 hyperactivity impairs autophagy and induces Paneth cell dysfunction
Intestinal macrophage LRRK2 kinase activity impairs Paneth cell function in Crohn’s disease.
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