Mitochondria interact directly with the nuclear pore complex via VDAC1–RANBP2 binding to sustain nuclear ATP levels.

Nature Reviews Immunology, Published online: 10 February 2026; doi:10.1038/s41577-026-01278-2A preprint by Heieis et al. shows that O-GlcNAcylation regulates the alternative activation of macrophages and their tissue residency through effects on cell cycle and metabolism.