We report a case of anaphylactic shock in an O patient transfused with a B platelet unit. The in vitro data suggest, but do not prove, that the reaction was mediated by recipient alpha-gal IgE. Furthe...

The lone star tick ( Amblyomma americanum Linnaeus) is a species commonly found in the southeastern U.S., but in recent years its populations have expanded northward, resulting in an increased risk of...

<span><b>Background/Objectives:</b> This study investigates the potential of <i>Anisakis</i> sp. as a novel source of α-Gal (Galα1-3Galβ1-4GlcNAc-R) epitopes capable of inducing allergic sensitization...

Abbreviations: AGS (alpha-gal syndrome), IgE (immunoglobulin E), ICD (International Classification of Diseases), HRSA (Health Resources and Services Administration)

We demonstrate a substantial incidence of adverse drug reactions and presumed anaphylaxis to crotaline antivenoms in an α-GAL endemic region, with F(ab')₂ antivenom associated with more rea...

Hypersensitivity reactions (HSRs) limit cetuximab use in KRAS wildtype advanced colorectal cancer, with a significant driver being pre-formed IgE antibodies against galactose-1,3-alpha-galactose (alph...

Allergic reactions in response to arthropod bites are a growing concern worldwide. Alpha-Gal syndrome (AGS) is a red meat allergy associated with IgE antibodies against galactose-alpha-1,3-galactos...

Evidence supporting the possibility of a new adverse event, TRAGS, is accumulating. This study quantifies how often Group O patients may be exposed to Group B antigen in Group B or AB plasma and/or pl...

Alpha-gal syndrome (AGS) was first described by Commins and Platts-Mills in 2009 as an IgE-mediated allergic reaction to galactose-alpha-1,3-galactose (alpha-gal) residues on nonprimate mammalian tiss...

Alpha-gal syndrome presenting in the emergency department: a case report

The α-gal syndrome (AGS) is a food allergy towards galactose‐α‐1,3‐galactose (α‐gal) present in mammalian meat and it usually develops after tick bite…

We report a case of a 40-year-old male who presented with sensation of throat closing and shortness of breath while at work at a meat processing facility. The differential diagnosis of shortness of br...

Decellularization does not completely remove the matrix-bound α-Gal epitopes in porcine acellular dermal matrix (pADM), and the presence of residual α-Gal epitopes could elicit adverse immunological r...

This study provides valuable insights that should be considered to improve TBDs surveillance and diagnostic strategies, as well as developing preventive measures to reduce tick bite exposure and TBD c...

The alpha-Gal syndrome (AGS) is an underdiagnosed tick-borne allergy characterized by both immediate and delayed IgE-mediated anaphylactic reactions to the galactose-alpha-1,3-galactose (alpha-Gal) ep...

This article is a narrative review exploring how research in French Guiana could unlock the mysteries surrounding Alpha-Gal Syndrome (AGS), a recently identified IgE-mediated allergy with delayed r...

The list of mandatory allergens provided by the European Regulation includes14 allergens but other foods are often involved in food-induced anaphylaxi…

The alpha-Gal syndrome (AGS) evolved as a catastrophic selection associated with anti-α-Gal IgM/IgG protective response against pathogen infection and tick-borne food allergy caused by IgE-type antibo...

Diagnostic cat and dog allergenic products contain alpha-gal

α-Gal syndrome (AGS) is an emerging tick-borne disease characterised by the development of specific immunoglobulin E (sIgE) antibodies against galactose-α-1,3-galactose (α-gal), a carbohydrate found i...

Alpha-Gal Syndrome after <em>I. scapularis</em> Tick Bite

Bone xenografts represent a promising alternative to autologous or allograft transplants, yet antigenicity in animal-derived tissues remains a major l…

This article presents the first clinical AGS case series in South Carolina, warranting further clinical and public education and a need for continued clinical research on this emerging tick-associated...

Small carbohydrates present a rich and complex conformational landscape whose accurate description is a significant challenge for computational molecular science, yet essential for understanding thei...

Mississippians are no strangers to ticks, but residents of the Magnolia State may be surprised to learn that these pesky parasites are capable of spreading a food allergy that makes red meat particula...

The trend of human tick-borne disease (TBD) incidence has increased exponentially over the past two decades. Limited healthcare access, substandard housing, socioeconomic fragility, and absence of gov...

The trend of human tick-borne disease (TBD) incidence has increased exponentially over the past two decades. Limited healthcare access, substandard housing, socioeconomic fragility, and absence of gov...

Alpha-gal syndrome (AGS) is a described meat allergy to an oligosaccharide, galactose-alpha-1,3-galactose (alpha-gal), present on mammalian cells and appears to be associated with the Amblyomma Americ...

115Background: Cetuximab has been shown to improve survival in patients with KRAS wildtype metastatic colorectal cancer. However, high rates of hypersensitivity reactions (HSRs) limit its use, with HS...

Screening tests for specific immunoglobulin E (sIgE) to food allergens, such as the multiple allergen simultaneous test (MAST), are widely used in patients with suspected food allergies in South Korea...

Background/Objectives: IgE to galactose-alpha-1,3-galactose (alpha-gal) is associated with Amblyomma americanum (lone star tick) bites, accounting for the regional distribution of the alpha-gal syndro...

An abstract is unavailable.

An abstract is unavailable.

Upon first exposure to cetuximab, hypersensitivity reactions can occur. We aimed to assess the utility of the basophil activation test (BAT) to alpha-gal and cetuximab for predicting severe reactions....

Purpose of Review Galactose-alpha-1,3-galactose (alpha-gal) is a ubiquitous singular oligosaccharide and a relevant emergent allergen, first reported in 2008, which caused severe and even fatal allerg...

Antibody-dependent enhancement (ADE) of bacterial infections occurs when blocking or inhibitory antibodies facilitate the infectivity of pathogens. In humans...

Galactose-alpha-1,3-galactose (alpha-gal) is a carbohydrate expressed by all mammals except for humans and certain old-world primates. It can be found…

Published in Toxicology Communications (Vol. 8, No. 1, 2024)

A 5-year-old boy with a history of asthma presented for a 1-year history of multiple episodes of emesis. What's the diagnosis?

Adverse rection to local anesthetic agents is uncommon with true hypersensitivity reaction less than 1 ​% of all adverse reactions. Allergic reactions…

In the northeastern USA, the distribution of lone star ticks (<i>Amblyomma americanum</i>) has expanded northward in recent decades, overlapping with the range of blacklegged ticks (<i>Ixodes scapular...