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Brian H Mathison

@allthingstox.com
295 followers 251 following 637 posts

Father, husband, scientist, & toxicologist; BA Biochem & Molecular Biology (UCSB); PhD Environmental Toxicology (UCI) 🧬Composite Transcription Factor Decoys. Chemical Carcinogenesis, Genetic Toxicology, & Predictive Technologies brianhmathison.substack.com

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Brian H Mathison @allthingstox.com · 02/04/2026
Looks like 16+ briefs filed today in Monsanto v Durnell. Few actually addressing the question before the court. Glyphosate toxicology is not being adjudicated. Pretty crazy. www.supremecourt.gov/docket/docke...
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Brian H Mathison @allthingstox.com · 19/03/2026
Maybe journalists could do better as when 4 Johns Hopkins Livable Future authors cite Zhang’s meta‑analysis, note that EPA HED and Judge Chhabria found serious methodological flaws, calling it effectively 'junk science.' Yet outlets like SciAm, CNN, and The Guardian still report it & omit ECHA/EFSA.
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Brian H Mathison @allthingstox.com · 19/03/2026
I’d disagree. Classic lies of omission shouldn’t be the bar by which professional journalism is judged adequate, when truth, fairness, independence, & accountability are routinely missing in glyphosate coverage. The IARC Monograph program cannot be compared to world regulatory authorities.
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Brian H Mathison @allthingstox.com · 05/03/2026
NotebookLM graphics can take pages of text and references and turn them into a surprisingly good visual that captures the main points I’d try to make. A picture really can be worth a 1000 words & sometimes it makes clear that the confident takes on social media missed the point.
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Brian H Mathison @allthingstox.com · 01/03/2026
Durnell v Monsanto, Glyphosate I've uploaded several rulings, briefs, and some of my additional writings, then asked for a “graphic summary,” and it wasn’t awful. I’ll expand on Substack in time, especially regarding monograph program limitations compared to regulatory consensus.
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Brian H Mathison @allthingstox.com · 26/02/2026
Lot’s on my mind, but like seeing Shadow, Jackie, and Punch coverage.
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Brian H Mathison @allthingstox.com · 26/02/2026
Glyphosate: Hitting New Lows in Journalism It is hard to know what is deteriorating faster, journalistic rigor or public understanding of science.
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Brian H Mathison @allthingstox.com · 25/02/2026
Not surprised glyphosate came up in this morning’s confirmation hearing for Casey Means. The real question: will the coverage dig into the actual science and regulatory record or just recycle the usual talking points? substack.com/@allthingsto...
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Brian H Mathison @allthingstox.com · 20/02/2026
Nope, "Reminder: Glyphosate is not carcinogenic, mutagenic, or reprotoxic, as concluded by the most recent scientific assessments by EFSA/ECHA. While acknowledging knowledge gaps, these assessments represent the most comprehensive evaluation of a pesticide ever conducted."
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Brian H Mathison @allthingstox.com · 20/02/2026
Reminder: Glyphosate is not carcinogenic, mutagenic, or reprotoxic, as concluded by the most recent scientific assessments by EFSA/ECHA. While acknowledging knowledge gaps, these assessments represent the most comprehensive evaluation of a pesticide ever conducted. www.efsa.europa.eu/sites/defaul...
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Brian H Mathison @allthingstox.com · 04/02/2026
The glyphosate saga is remarkable on many levels. Expert testimony proved essential, including that of toxicologist William Sawyer in Pilliod v. Monsanto Co., a case that produced a verdict exceeding $2 billion and ultimately contributed to more than $10 billion in settlements.
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Brian H Mathison @allthingstox.com · 03/02/2026
Yes, there’s a strange disconnect with some computational tools. Writing Python, using RDKit, or fetching a PubChem CID is easy, yet several publications (and posts) still miss basic biology & chemistry (e.g., like zwitterionic forms in the human body). pubchem.ncbi.nlm.nih.gov/compound/248...
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Brian H Mathison @allthingstox.com · 02/02/2026
www.chemistryworld.com/news/the-che...
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Brian H Mathison @allthingstox.com · 05/01/2026
Best to cite EFSA and ECHA, which conducted the most comprehensive glyphosate assessments and found no critical health concerns for carcinogenicity, mutagenicity, or reproductive toxicity (while acknowledging data gaps), then ask why the NYT article omits this. www.efsa.europa.eu/sites/defaul...
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Brian H Mathison @allthingstox.com · 05/01/2026
EFSA and ECHA conducted the most exhaustive glyphosate evaluation to date, reviewing vast evidence and finding no critical health concerns like carcinogenicity, mutagenicity, or reprotoxicity, even while noting data gaps. Why does the NYT article omit this? www.efsa.europa.eu/sites/defaul...
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Brian H Mathison @allthingstox.com · 17/12/2025
Glyphosate / Roundup Litigation Update Monsanto v. Durnell (No. 24-1068) was distributed for conference today (Dec. 16, 2025). Respondent also filed a 13-page supplemental brief today. A decision on certiorari pending w/ conference date of Jan. 9, 2026. substack.com/@allthingsto...
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Brian H Mathison @allthingstox.com · 23/11/2025
Pausing on the Pond Trail
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Brian H Mathison @allthingstox.com · 30/10/2025
About 1 in 5 adults globally still use tobacco products (as of the 2024 data from WHO) - many remain at risk of the many harms associated with tobacco use. www.who.int/publications...
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Brian H Mathison @allthingstox.com · 25/10/2025
Nope, 1802 – Hôpital des Enfants Malades (Paris, France) 1852 – Great Ormond Street Hospital (London, England) 1855 – Children’s Hospital of Philadelphia (CHOP, USA) ourworldindata.org/child-mortal...
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Brian H Mathison @allthingstox.com · 24/10/2025
Perplexity AI, Synthetic Certainty, & Glyphosate substack.com/@allthingsto...
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Brian H Mathison @allthingstox.com · 23/10/2025
Casey Means hearing next week - some thoughts substack.com/@allthingsto...
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Brian H Mathison @allthingstox.com · 20/10/2025
Glyphosate update: [~1,188 words, or ~27 tweet equivalents, posts always fleeting here] substack.com/@allthingsto...
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Brian H Mathison @allthingstox.com · 16/10/2025
Lead and Protein Powder - IRONY AHEAD substack.com/profile/1098...
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Brian H Mathison @allthingstox.com · 15/10/2025
Generative Artificial Intelligence (GAI) - Yikes Note: substack.com/profile/1098...
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Brian H Mathison @allthingstox.com · 13/10/2025
Was hoping to hear more about possible solutions & didn’t catch any thoughts on the Surgeon General nominee? Cabinet secretaries serve at the pleasure of the president, and even with the current polling, we may be in for a few more years. Each day a new adventure. www.pewresearch.org/short-reads/...
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Brian H Mathison @allthingstox.com · 13/10/2025
In this instance, best consider the most recent reviews that address monograph 112. Glyphosate is not carcinogenic, mutagenic, or reprotoxic, as concluded by EFSA/ECHA and while acknowledging knowledge gaps, these assessments represent the most comprehensive evaluation of a pesticide ever conducted.
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Brian H Mathison @allthingstox.com · 13/10/2025
In these instances, best cite recent reviews. Glyphosate is not carcinogenic, mutagenic, or reprotoxic, as concluded by EFSA/ECHA and while acknowledging knowledge gaps, these assessments represent the most comprehensive evaluation of a pesticide ever conducted. www.efsa.europa.eu/sites/defaul...
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Brian H Mathison @allthingstox.com · 17/09/2025
Kauai
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Brian H Mathison @allthingstox.com · 15/09/2025
Fleeting thoughts on toxicology open.substack.com/pub/brianhma...
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Brian H Mathison @allthingstox.com · 14/09/2025
Another sunrise, funny how that happens each day
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Brian H Mathison @allthingstox.com · 14/09/2025
Channeling Socrates
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Brian H Mathison @allthingstox.com · 12/09/2025
Limahuli Garden & Preserve
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Brian H Mathison @allthingstox.com · 09/09/2025
Kauai has an herbicide solution - organic, non-GMO. #buylocal.
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Brian H Mathison @allthingstox.com · 08/09/2025
Carpe diem! For time is money, yet unlike money it is both free and priceless; an illusory treasure granted for use but never to own, to be spent but never kept, and once lost, gone forever.
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Brian H Mathison @allthingstox.com · 07/09/2025
Note to self, spend time wisely
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Brian H Mathison @allthingstox.com · 05/09/2025
Sent via substack, if initials KB, already connected
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Brian H Mathison @allthingstox.com · 02/09/2025
The 'truth' started @31:20 with Monograph Program 20Mar2015, then as told by: Nathan Donley, Brett Wisner, Carey Gillam, and Bart Elmore. No objective science or mention of the 2023 ECHA and EFSA assessements (180,000 page dossier). 🚫carcinogenic, 🚫 mutagenic www.efsa.europa.eu/sites/defaul...
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Brian H Mathison @allthingstox.com · 29/08/2025
Reminded why I write on Substack and have an account here.
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Brian H Mathison @allthingstox.com · 24/08/2025
Looking towards Coal Oil Point, morning walk almost each day. Blessed
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Brian H Mathison @allthingstox.com · 18/08/2025
Arnold Schwarzenegger Is Ready To Take On Gavin Newsom | Vanity Fair share.google/Om4pcpKb57od... Not a popular opinion, but I do agree.
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Brian H Mathison @allthingstox.com · 19/05/2025
Albert D. Grantges v. Monsanto Company substack.com/profile/1098...
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Brian H Mathison @allthingstox.com · 09/05/2025
I've decided on my picks for Surgeon General, HHS, FDA, CDC, and CMS leadership. It's all the same person: William E. Flanary, MD. He already plays everyone in the healthcare system—might as well make it official !
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Brian H Mathison @allthingstox.com · 01/05/2025
In PubMed >4000 since the 2015 monograph, EFSA reapproval based on ~2400. The most comprehensive and transparent assessment of a pesticide that EFSA and the EU Member States have ever carried out. Yet, there are some gaps. * www.efsa.europa.eu/sites/defaul... * www.efsa.europa.eu/en/efsajourn...
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Brian H Mathison @allthingstox.com · 27/04/2025
Beautiful day after morning rain
Graduation 🎓 of a JD today, proud parents
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Brian H Mathison @allthingstox.com · 10/04/2025
Glyphosate Petition: Some Thoughts (The Good, The Bad)🔗 - open.substack.com/pub/brianhma...
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Brian H Mathison @allthingstox.com · 31/03/2025
A Monday update on glyphosate litigation events - more to come as time permits substack.com/profile/1098...
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Brian H Mathison @allthingstox.com · 17/03/2025
Interesting article—linking to EFSA/ECHA could add value. Glyphosate was deemed non-carcinogenic, non-mutagenic, and non-reprotoxic in the most thorough pesticide review ever, despite acknowledged gaps. An existential litigation threat to Bayer remains. www.efsa.europa.eu/sites/defaul...
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Brian H Mathison @allthingstox.com · 05/03/2025
Toxicologist: The LD50 test is helpful for assessing acute toxicity but it fails to capture the complexity of chemical toxicity, especially chronic health effects like cancer, reproductive toxicity, & ecological impacts. DDT (113 mg/kg), Caffeine (150 mg/kg), Both class 3 (toxic) - similar? - no
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Brian H Mathison @allthingstox.com · 03/03/2025
Thanks for helping to raise public awareness... 👍 #WorldBirthDefectsDay Burden of Congenital CMV Infection: A Narrative Review and Implications for Public Health Interventions doi.org/10.3390/v160...
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Brian H Mathison @allthingstox.com · 28/02/2025
Worked on update & 1 min summary. To actually address microbiome, carcinogenicity, formulations, the 9th circuit remand (NRDC v. EPA), neurodegenerative and reproductive toxicology, inflammation, human exposure, ecotoxicology, & forest fires. Might need, ...oh... >180,000 pages as EFSA evaluated?
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