Open science often centers around publications and data transparency. This Perspective discusses how and why disseminating results to study participants is essential for maximizing the values and bene...

Parents want accountability after study went disastrously wrong, Science and Retraction Watch investigation reveals

Author summary Why was this study done? Lenacapavir has shown remarkable efficacy in preventing HIV acquisition in clinical trials and recently became available in South Africa for early implementa...

In this Editorial, Rebecca Grais outlines how COVID-19 transformed viral outbreak responses from a predominantly public health challenge into a political and security concern, highlighting the challen...

Although research has bipartisan support in the US Congress, and trust in science is above 75% across the country, the Trump administration seems as determined as ever to mortally wound the nation’s s...

The Office of Management and Budget (OMB) proposes to revise the Guidance for Federal Financial Assistance to improve government- wide policies and requirements related to the management of grants, co...

Elected in 2026

The 2022 mpox outbreak quickly made headlines and galvanized global attention; but the epidemic is not over. In this Perspective, Rosamund Lewis and colleagues highlight ongoing mpox outbreaks across ...

Large open health datasets present unique opportunities for studies that when well-designed, conducted, and reported, can offer valuable contributions to health and medicine. However, recent years hav...

In a retrospective cohort study, Yiran E Liu and colleagues investigate all-cause and cause-specific mortality during and following incarceration in Brazil.

Gavin Yamey and co-authors discuss approaches to providing support for middle-income countries transitioning away from health aid.

Using data from 22 prospective cohort studies, Erfan Tasdighi and colleagues investigate the relationships among smoking burden, intensity, and cessation duration across multiple cardiovascular outcom...

In this Perspective, Madhukar Pai and colleagues highlight that while international health aid cuts are impacting the tuberculosis response, they also present an opportunity to shift towards a more eq...

In recognition of World AIDS Day 2025, this Perspective by Gregory Folkers and Anthony Fauci reflects on the progress made in antiretroviral treatments and prevention of HIV/AIDS, highlighting promisi...

In recognition of World AIDS Day 2025, this Perspective by Gregory Folkers and Anthony Fauci reflects on the progress made in antiretroviral treatments and prevention of HIV/AIDS, highlighting promisi...

Countries across Africa face health crises driven by aid cuts, shifting demography, and infectious and environmental threats. Renewed public health strategies, smarter investment, and stronger surveil...

As PLOS Medicine enters a new chapter, its leadership sets out a bold editorial vision grounded in evidence, impact and equity. In a rapidly evolving global health landscape, the journal reaffirms its...

A complete, transparent, and accessible protocol is critical for the planning, conduct, reporting, and external review of randomised trials The SPIRIT (Standard Protocol Items: Recommendations for I...

Dr. Peter Marks, a veteran of the agency, wrote that undermining confidence in vaccines is irresponsible and a danger to public health.

The move comes after a series of cuts to prevention and treatment efforts worldwide. Some functions might be moved to another agency, officials said.

In a world beset by attempts to undermine scientific evidence and evidence-based policy, we emphasize their important role in helping humanity rise to the challenges of our time.

Since its founding over twenty five years ago PLOS has been dedicated to advancing open science, ensuring that knowledge is accessible to…

The president talks about trans athletes ‘invading’ women’s sports, while doing nothing at all to elevate, fund or support women athletes

Drugmakers — major beneficiaries of NIH-backed university research — have been largely silence on the Trump administration's cuts to agency research payments.

Dr. Anthony S. Fauci, who was one of the nation’s top health officials for decades, had received death threats during the coronavirus pandemic. He has hired his own security detail.

Researchers facing

The U.S. has recorded its first fatal case of H5N1 bird flu, in a person from Louisiana who contracted the virus from infected chickens and wild birds in a backyard flock.

In 2024, several human infections with highly pathogenic clade 2.3.4.4b bovine influenza H5N1 viruses in the United States raised concerns about their capability for bovine-to-human or even human-to-h...

A bereaved mother’s case against our grief-phobic culture.

We evaluated the use of chimeric antigen receptor-modified T cells targeting GD2 (GD2-CART) for H3K27M+ diffuse midline glioma (DMG), finding that intravenous administration of GD2-CART, followed by i...