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Alicia Che

@aliciache.bsky.social
177 followers 138 following 6 posts

Asst prof @ Yale psychiatry, mom of 2

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Reposted by Alicia Che
Matt Girgenti @mattgirgenti.bsky.social · 18/06/2025
Very proud of our new #SingleCell work on #PTSD and #MDD out in @nature.com today. Paper: www.nature.com/articles/s41... News and views: www.nature.com/articles/d41... Press: medicine.yale.edu/news-article... Data: doi.org/10.5281/zeno... Code: github.com/mjgirgenti/P...
nature.com
Single-cell transcriptomic and chromatin dynamics of the human brain in PTSD - Nature
A comprehensive analysis of the cell-specific molecular regulatory mechanisms underlying post-traumatic stress disorder in the human prefrontal cortex.
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Reposted by Alicia Che
Yale Kavli Institute for Neuroscience @kavliatyale.bsky.social · 09/05/2025
In a new @yale.edu study, researchers led by @mattgirgenti.bsky.social from #YalePsychiatry used a comprehensive multi-omic approach to analyze postmortem brain 🧠 genomics and investigate the molecular differences 🧬 in PTSD and major depressive disorder 🔍
medicine.yale.edu
A Multi-Omic Approach Implicates Novel Protein Dysregulation in Post-Traumatic Stress Disorder
Yale scientists, led by senior author Matthew Girgenti, PhD, assistant professor of psychiatry, established a brain multi-omic and multi-region analysis
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Reposted by Alicia Che
Matt Girgenti @mattgirgenti.bsky.social · 30/04/2025
Excited to share our latest study of the PTSD prefrontal cortex out @GenomeMedicine. rdcu.be/ejZ3T Our systems biology approach established a brain multi-omic, multi-region analysis comprising individuals with PTSD and MDD
rdcu.be
A multi-omic approach implicates novel protein dysregulation in post-traumatic stress disorder
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Reposted by Alicia Che
Alex Kwan @alexkwan.bsky.social · 02/04/2025
Our latest study identifies a specific cell type and receptor essential for psilocybin’s long-lasting neural and behavioral effects 🍄🔬🧠🧪 Led by Ling-Xiao Shao and @ItsClaraLiao Funded by @NIH @NIMHgov 📄 Read in @nature.com - www.nature.com/articles/s41... 1/12
nature.com
Psilocybin’s lasting action requires pyramidal cell types and 5-HT2A receptors - Nature
A pyramidal cell type and the 5-HT2A receptor in the medial frontal cortex have essential roles in psilocybin’s long-term drug action.
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Alicia Che @aliciache.bsky.social · 07/03/2025
Soohyun is a friend and colleague who is kind, generous, and absolutely brilliant. Sending love. We stand together ❤️
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Reposted by Alicia Che
Mark Cuban @mcuban.bsky.social · 09/02/2025
This is the most relevant article to NIH and research cuts I’ve seen. Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !” globalnews.ca/news/9793403...
globalnews.ca
How a Canadian scientist and a venomous lizard helped pave the way for Ozempic - National | Globalnews.ca
In 1984, Dr. Daniel Drucker, an endocrinologist from the University of Toronto, discovered a hormone that helped pave the way for popular diabetes drugs such as Ozempic.
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Reposted by Alicia Che
Ezra Levin ❌👑 @ezralevin.bsky.social · 09/02/2025
Folks trying to save USAID are trying to counterprogram Musk's $40 million Super Bowl ad. They're asking everyone to share this video as widely as you can today: www.youtube.com/watch?v=PqUE...
youtube.com
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Reposted by Alicia Che
Sam Bagenstos @sbagen.bsky.social · 08/02/2025
Indirect Costs and Trump's Attack on Independent Voices. My latest post: buttondown.com/sbagen/archi...
buttondown.com
Indirect Costs and Trump's Attack on Independent Voices
By Samuel Bagenstos A strong democracy requires a robust independent sector. Organizations and associations that stand apart from the governing state regime...
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Alicia Che @aliciache.bsky.social · 08/02/2025
It’s not easy to keep a cool head with muzzle velocity. Great article. Will share with all my trainees. (Gift without paywall) www.nytimes.com/2025/02/02/o...
nytimes.com
Opinion | Don’t Believe Him (Gift Article)
Look closely at the first two weeks of Donald Trump’s second term and you’ll see something very different than what he wants you to see.
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Alicia Che @aliciache.bsky.social · 07/02/2025
Was hoping to share good news at a better time but realized it may not come for 4 years, so here it is! First paper from the lab. We show a transient L5 to L2/3 connection in developing cortex that drives activity-dependent maturation of upper-layer circuits. www.nature.com/articles/s41...
nature.com
Translaminar synchronous neuronal activity is required for columnar synaptic strengthening in the mouse neocortex - Nature Communications
The development of translaminar cortical circuits remains incompletely understood. Here authors show cortical layer 5 provides translaminar inputs to layer 2/3 during development, strengthening layer ...
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Reposted by Alicia Che
Daniel Gonzales @dgonzales1990.bsky.social · 31/01/2025
Really proud to see my postdoc work out!! We used flexible, semi-transparent NeuroGrids to record traveling waves while simultaneously mapping cellular and subcellular dynamics with two-photon imaging www.science.org/doi/10.1126/...
science.org
Touch-evoked traveling waves establish a translaminar spacetime code
Translaminar spacetime patterns organized by feedback-dependent cortical circuits support sparse traveling waves.
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Reposted by Alicia Che
Konrad Kording @kordinglab.bsky.social · 30/01/2025
Dendrites doing AI problems, so great to see the increased activity! www.nature.com/articles/s41...
nature.com
Dendrites endow artificial neural networks with accurate, robust and parameter-efficient learning - Nature Communications
Artificial neural networks, central to deep learning, are powerful but energy-consuming and prone to overfitting. The authors propose a network design inspired by biological dendrites, which offe...
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