Mead suffered a broken left wrist July 27 when he was hit by a pitch in his second at-bat for the Red Sox. He arrived in a trade while enjoying a breakout season with the Nationals.

It's die-or-die for the Red Sox in the Bronx on Wednesday.

Ceddanne Rafaela and Jarren Duran also showed signs of being less than 100 percent in Tuesday's opener.

Ceddanne Rafaela and Jarren Duran also showed signs of being less than 100 percent in Tuesday's opener.

The Sox were one of the least-productive teams in baseball against pitches of 95 miles per hour or greater this year.

Follow along as Globe reporters Peter Abraham, Tim Healey, and Alex Speier bring you live analysis and insight from Yankee Stadium.

The Sox were one of the least-productive teams in baseball against pitches of 95 miles per hour or greater this year.

Tolle and Schlittler both learned from current Red Sox director of pitching Ben Buck, who saw them achieve tremendous success with four-seamers, sinkers, and cutters.

The Walpole native and Northeastern product arrived at Thursday night's start for the Yankees against the Red Sox at Fenway Park as the American League's ERA leader.

A year ago, Tolle was just a rookie reliever in the postseason. Now, he'll likely lead Boston's rotation in New York.

A year ago, Tolle was just a rookie reliever in the postseason. Now, he'll likely lead Boston's rotation in New York.