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Alex Lercher

@alercher.bsky.social

610 followers 888 following 32 posts

Immunology | Virology | Junior Group Leader | Heidelberg University | opinions are my own.

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Alex Lercher @alercher.bsky.social · 27/12/2024

Location, infection history, antigen persistence shape the phenotype of tissue-resident T cells (Trm), challenging the idea of a universal framework for Trm identity across organs and diseases. High/low antigen immunogenicity may add another layer... @cp-immunity.bsky.social tinyurl.com/49dkc3j7

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Alex Lercher @alercher.bsky.social · 15/12/2024

A commensal bacterium triggers systemic antibody responses via skin lymphoid structures and can be engineered as a topical vaccine – great therapeutic potential! Two studies in @nature.com.web.brid.gy by the Fischbach and Belkaid labs tinyurl.com/5yahn47t tinyurl.com/4n4btxap

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Alex Lercher @alercher.bsky.social · 25/11/2024

Link to publication and short graphical abstract below! www.cell.com/immunity/ful...

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Alex Lercher @alercher.bsky.social · 17/11/2024

...aaaand, we even made the cover at Immunity! Big thanks to all the funding agencies, collaborators, mentors and friends who made this paper possible!

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Alex Lercher @alercher.bsky.social · 17/11/2024

This allowed recovered mice to be better at combatting secondary influenza A virus infection - an effect that seemed to be solely mediated by recovered alveolar macrophages, independent of SARS2-memory T cells!

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Alex Lercher @alercher.bsky.social · 17/11/2024

We found that alveolar macrophages retain epigenetic remodeling post COVID-19 that allows them to hyper-induce antiviral genes after encountering a secondary viral pathogen

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Alex Lercher @alercher.bsky.social · 17/11/2024

How do past viral infections influence future viral diseases? We found that SARS-CoV-2 recovery protected from severe influenza A virus disease. But how come? There seemed to be some antigen-independent immunological memory going on.. Paper at Immunity: www.sciencedirect.com/science/arti...

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Alex Lercher @alercher.bsky.social · 15/11/2024

Chronic autoimmunity rewires metabolism in progenitors, correlating with innate immune memory formation in macrophages that increases antibacterial activity but might also aggravate autoimmune diseases? shorturl.at/SZ1Ww #CellStemCell

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Alex Lercher @alercher.bsky.social · 13/11/2024

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Alex Lercher @alercher.bsky.social · 13/11/2024

We found that alveolar macrophages retain epigenetic remodeling post COVID-19 that allows them to hyper-induce antiviral genes after encountering a secondary viral pathogen

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