iiinova — where your digital self keeps evolving

Reposted by Alessio Gerussi

NEJM.org @nejm.org · 29/10/2025

The prognosis of liver disease depends on the extent of fibrosis, which is usually staged with the use of liver biopsy. The limitations of biopsy have led to the development of noninvasive tests, which the authors review. Learn more: nej.md/4hwZMgj #MedSky #GastroSky

Review Article
Noninvasive Assessment of Liver Fibrosis
Laurent Castera, M.D., Ph.D., Mary E. Rinella, M.D., and Emmanuel A. Tsochatzis, M.D., Ph.D.

A figure showing the diagnosis, staging, and progression of liver fibrosis.

The NEJM identity sits at the bottom.

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Alessio Gerussi @aleger87.bsky.social · 21/07/2025

HOTSPoT paves the way for scalable, explainable, and accessible AI in liver pathology. Open science, clinical relevance, and technical excellence — all in one model. Congrats to the entire team! #DigitalPathology #OpenSource #AIinMedicine

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Alessio Gerussi @aleger87.bsky.social · 21/07/2025

Behind this innovation is a multidisciplinary, international team — but a special shoutout to Giorgio Cazzaniga, who led dataset creation, annotation, model design & implementation. A stellar example of clinician-engineering leadership. 🙌

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Alessio Gerussi @aleger87.bsky.social · 21/07/2025

Clinical validation? Yes. In 35 liver biopsies, HOTSPoT's automated tract count matched human observers (κ = 0.90) and correlated strongly with fibrosis stage (r = 0.87). A true step forward in reproducible pathology. 📈🩺

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Alessio Gerussi @aleger87.bsky.social · 21/07/2025

HOTSPoT isn't just a model — it's a tool. It's released in TorchScript format, integrates with QuPath, and includes a custom WSInfer pipeline for WSI-level inference. ⚙️ Code & model 👉 github.com/Gizmopath/HO...

github.com

GitHub - Gizmopath/HOTSPoT: Hematoxylin & Eosin-based Open-access Tool for Segmentation of Portal Tracts

Hematoxylin & Eosin-based Open-access Tool for Segmentation of Portal Tracts - Gizmopath/HOTSPoT

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Alessio Gerussi @aleger87.bsky.social · 21/07/2025

Trained on 223 cases and tested across 5 international centers, HOTSPoT achieved Dice scores up to 0.92, showing minimal domain shift. That means: robust performance across scanners, stains, and disease contexts. 🌍📊

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Alessio Gerussi @aleger87.bsky.social · 21/07/2025

Liver histology is essential in diagnosing autoimmune and inflammatory diseases — but manual annotation is time-consuming and variable. HOTSPoT tackles this with automated, high-performance segmentation of portal tracts in H&E-stained slides. 🧠🧫

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Alessio Gerussi @aleger87.bsky.social · 21/07/2025

🔥 HOTSPoT sets a new benchmark in liver pathology: open-source, accurate, and externally validated tool for portal tract segmentation. A brilliant team effort led by Giorgio Cazzaniga — whose vision and drive made it possible 👏 rdcu.be/ew7qh #AI #Digitalpathology

rdcu.be

Automating liver biopsy segmentation with a robust, open-source tool for pathology research: the HOTSPoT model

npj Digital Medicine - Automating liver biopsy segmentation with a robust, open-source tool for pathology research: the HOTSPoT model

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Alessio Gerussi @aleger87.bsky.social · 10/06/2025

Great visit to EKFZ Digital Health Institute! Gave a talk at Jakob Kather’s lab, had great 1:1s with team members, and visited our PhD student Elisa Merelli, who's spending part of her PhD here💡🔬 #DigitalHealth #AI #Research @jnkt.bsky.social @janclusmann.bsky.social

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Reposted by Alessio Gerussi

NEJM AI @ai.nejm.org · 22/05/2025

This article analyzes how nonexperts perceive AI-generated medical advice, finding that it is often rated as accurate as — or better than — doctor responses, raising concerns about overreliance and potential harm from incorrect guidance. Full article: nejm.ai/43xKDG0 #AI #MedSky #MLSky

nejm.ai

People Overtrust AI-Generated Medical Advice despite Low Accuracy

This article presents a comprehensive analysis of how artificial intelligence (AI)–generated medical responses are perceived and evaluated by nonexperts. We conducted a study in which a total of 30...

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Reposted by Alessio Gerussi

NEJM.org @nejm.org · 03/04/2025

In the SELECT-GCA phase 3 trial involving patients with giant-cell arteritis, the oral Janus kinase inhibitor upadacitinib (15 mg) significantly improved remission of disease, with less glucocorticoid use. Full trial results: nej.md/3XBdkia #MedSky

A graph showing the time to first flare of giant-cell arteritis through week 52.

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Reposted by Alessio Gerussi

Jakob Nikolas Kather @jnkt.bsky.social · 27/03/2025

Happy to share our latest paper in @ai.nejm.org, led by Isabella Wiest: "Deidentifying Medical Documents with Local, Privacy-Preserving Large Language Models: The LLM-Anonymizer" ai.nejm.org/doi/full/10.... You can use our open source tool with local LLMs to robustly de-identify medical documents.

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Reposted by Alessio Gerussi

il Post @ilpost.it · 16/03/2025

Il 18enne italiano è arrivato quarto in Australia, diventando il secondo pilota più giovane di sempre a fare punti dopo Max Verstappen ilpost.link/Scna5U9zdB

ilpost.link

Il grande esordio di Andrea Kimi Antonelli in Formula 1 - Il Post

Il 18enne italiano è arrivato quarto in Australia, diventando il secondo pilota più giovane di sempre a fare punti dopo Max Verstappen

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