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albertsxue.bsky.social @albertsxue.bsky.social · 02/03/2026

My preprint on keju, a statistical tool for Massively Parallel Reporter Assay (MPRA) data, is out! keju improves sensitivity, calibration, and reliability over previous methods by closely modeling important uncertainty sources in MPRAs. Check it out: www.biorxiv.org/content/10.6... (1/n)

biorxiv.org

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Harold Pimentel @hjp.bsky.social · 29/09/2025

Super excited to get this out. This collab started a few years ago and is the first paper from it. Here, with experimental and computational approaches we: 1. establish that cell villages can be just as accurate (one might argue more accurate!) than arrayed-based designs bsky.app/profile/bior...

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Jingyou Rao @jingyour.bsky.social · 04/08/2025

How do we decouple the effects of two functional phenotypes in protein deep mutational scanning (DMS)? Meet Cosmos, our new statistical framework for causal inference in multi-phenotype DMS. www.biorxiv.org/content/10.1... [1/n]

biorxiv.org

Cosmos: A Position-Resolution Causal Model for Direct and Indirect Effects in Protein Functions

Multi-phenotype deep mutational scanning (DMS) experiments provide a powerful means to dissect how protein variants affect different layers of molecular function, such as abundance, surface expression...

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Jerome @jeromics.bsky.social · 30/06/2025

Check out our new preprint on Lilace, a statistical tool for scoring FACS-based deep mutational scanning experiments! Lilace directly models the shift between variant fluorescence distributions and provides score uncertainty estimates to better assess reliability and reproducibility. (1/3)

biorxiv.org

Accurate variant effect estimation in FACS-based deep mutational scanning data with Lilace

Deep mutational scanning (DMS) experiments interrogate the effect of genetic variants on protein function, often using fluorescence-activated cell sorting (FACS) to quantitatively measure molecular ph...

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Seungsoo Kim @seungsookim.bsky.social · 25/04/2025

I am hiring for a research technician role in my new lab at UC Irvine studying how transcription factors control cell identity. If you know any graduating undergrads or postbacs looking for a position, please spread the word! Apply by May 9 for full consideration. recruit.ap.uci.edu/JPF09594

recruit.ap.uci.edu

Junior / Assistant Specialist: Kim Lab, Developmental & Cell Biology

University of California, Irvine is hiring. Apply now!

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Katherine Xue @ksxue.bsky.social · 19/11/2024

Hi friends new and old! I study how microbes interact and evolve in complex communities like the human gut microbiome.🦠🧬💩 I'm thrilled to share that I'm starting a lab at UC Irvine in April 2025 and am recruiting at all levels - please spread the word! kxuelab.com More about my work below...🧵1/n

kxuelab.com

Xue lab at UC Irvine

Ecology and evolution in the human gut microbiome

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Jingyou Rao @jingyour.bsky.social · 30/10/2023

Meet Rosace, a robust deep mutational scanning analysis tool that incorporates positional information and mean-variance shrinkage. Check it out if you are running DMS experiments or handling DMS data! (1/n) www.biorxiv.org/content/10.1...

biorxiv.org

Rosace: a robust deep mutational scanning analysis framework employing position and mean-variance sh...

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

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