iiinova — where your digital self keeps evolving

Albada Lab @albadalab.bsky.social · 12/03/2026

@etienneverhoeff.bsky.social #ADVoetbalpodcast Dit is natuurlijk VfL Bochum, met het lied 'Bochum'. De club doet veel aan Feyenoord denken: matig bestuur, vaak slecht voetbal, soms een opleving, maar vooral heel veel passie en liefde voor de club!

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Albada Lab @albadalab.bsky.social · 26/02/2026

Great lecture by Albert Wong from the @utwente.bsky.social given at @w-u-r.bsky.social. He showed that chemical computation networks have distinct advantages over current electronically driven (and demanding) methods of computation. Rational design of computable chemical reaction networks = here!

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Albada Lab @albadalab.bsky.social · 24/02/2026

Look what the mailman dropped in: the Nobel Chemistry coloring book composed by the one and only @vsaggiomo.bsky.social As chemistry nerd with kids I had to have it to see if I can spoil them in at least two ways 😉

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Albada Lab @albadalab.bsky.social · 12/02/2026

Congratulations Marnix! A role that will suit you well.

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Reposted by Albada Lab

Dolf Weijers @dolfweijers.bsky.social · 28/01/2026

www.wur.nl/en/vacancy/f... Become our new colleague (and next door neighbor) and lead a chair/group/department of Biophysics at Wageningen University. Reach out to me for info and please spread!!!

wur.nl

Full Professor and Chair Laboratory of Biophysics

We are looking for a Full Professor in the Biophysics chair group, part of Wageningen University & Research (WUR)

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Albada Lab @albadalab.bsky.social · 19/01/2026

Nicest view from the attic window this year!

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Reposted by Albada Lab

Cees Dekker @ceesdekker.bsky.social · 09/01/2026

Latest #CDlab paper on nanopore protein sequencing now published in JACS: pubs.acs.org/doi/full/10.... Here, Justas Ritmejeris, Xiuqi Chen, collaborator Bauke Albada, and me developed a conjugation chemistry strategy for nanopore sequencing of natural peptides!

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Reposted by Albada Lab

Stephan Hacker @stephanhacker2.bsky.social · 03/12/2025

"Novel Covalent Inhibitors and Where to Find Them" I was very excited that Madeline Kavanagh, Marc Baggelaar, Rita Petracca and I were awarded a focus session at #NWOCHAINS. We had an amazing program with talks by Marta Artola, Kevin Neumann and Dieuwertje Streefkerkand a panel discussion. (1/3)

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Reposted by Albada Lab

Stephan Hacker @stephanhacker2.bsky.social · 03/12/2025

Insightful talk by Dieuwertje Streefkerk at #NWOCHAINS. She talked about their synthetic work on stereochemically defined sulfur(VI) electrophiles and their use as #CovalentInhibitors on the example of chymotrypsin inhibition. onlinelibrary.wiley.com/doi/full/10.... #ChemSky #ChemBio #Electrophiles

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Albada Lab @albadalab.bsky.social · 13/11/2025

Breakthrough paper deposited as preprint on @biorxivpreprint.bsky.social! Another major boundary removed on the path to achieve nanopore sequencing on biological proteins. Very happy with this collaboration with the lab of @ceesdekker.bsky.social!! Go check it out.

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Albada Lab @albadalab.bsky.social · 10/11/2025

Here are links to two seminal papers on the application of biogenic tyrosine click to generate ADCs (pubs.acs.org/doi/10.1021/...) and BiTEs (pubs.acs.org/doi/10.1021/...).

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Albada Lab @albadalab.bsky.social · 10/11/2025

I thank the reviewers for their constructive comments that helped us to improve the paper, and the editor for assisting us in the finalization of this paper! Massive thanks to @chemicalscience.rsc.org, the primary Diamond OA journal for the chemical community!

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Albada Lab @albadalab.bsky.social · 10/11/2025

SPOCQ has the great advantage over SPAAC as the proteinogenic amino acid tyrosine offers direct access to a rapid and clean method for protein modification, especially to convert therapeutic antibodies into antibody-drug conjugates (ADCs) and bispecific T cell engagers (BiTEs) (vide infra).

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Albada Lab @albadalab.bsky.social · 10/11/2025

With deltaH++ of <2 kcal/mol, these cycloadditions are entropy-driven. This has been mentioned before in the literature, but now we have the exact numbers, obtained by stopped-flow spectroscopic analysis! Reaction rates in SPAAC but not in SPOCQ correlated to sp-sp3 bond angles!

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Albada Lab @albadalab.bsky.social · 10/11/2025

We used a stable quinone and a range of strained cyclic alkenes and alkynes such as BCN and DBCO for in-depth kinetic studies of the SPOCQ click reaction (which is typically >100 times faster than the more commonly used SPAAC).

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Albada Lab @albadalab.bsky.social · 10/11/2025

For this paper, Yuri Damen grew crystals for the most-applied strained alkyne click reagents: DBCO (3077 literature references, left structure) and BCN (1680 literature references, right structure). Look how gorgeous they are! sp-sp3 bond angles are 154.2/154.5 in BCN and 152.3/154.2 in DBCO.

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Albada Lab @albadalab.bsky.social · 23/09/2025

Eerste beflijsters weer gezien in de uiterwaarden. Elk jaar trekken deze noordelijke (niet in NL) broedvogels weer door, in het voorjaar in april, in het najaar in en rond oktober (piek rond 11-10). Als je in halfopen landschap twee stukken hout tegen elkaar hoort slaan, kijk dan goed rond!

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Reposted by Albada Lab

Cees Dekker @ceesdekker.bsky.social · 13/08/2025

WORK! I currently have 5 (!) open positions for postdocs/PhD students in our CDlab for projects: - Nanopore protein sequencing - Archaeal CDV cell division - Microfluidics for synthetic cells - Nuclear Pore Complex - Origami mimics of peroxisomes Please apply! ceesdekkerlab.nl/come-join-us/ RT=👍

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Albada Lab @albadalab.bsky.social · 12/08/2025

Great opportunities in the lab of Steven Verhelst in Leuven, Belgium. A fantastic lab and place to start your career!

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Albada Lab @albadalab.bsky.social · 23/04/2025

Jahoor, er kon wel wat geregeld worden, en of mijn moeder even wilde wachten in de keuken. Ze hebben nog nooit zo lekker geluncht bij de voedselbank in Zwolle. #held #JonnieBoer #RIP

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Albada Lab @albadalab.bsky.social · 23/04/2025

Geschokt door het overlijden van Jonnie Boer van #DeLibrije. Heb er nooit gegeten, maar toen mijn moeder op jacht ging voor broodjes voor lunch van de voedselbank medewerkers, en ze als antwoord op haar schietgebedje Jonnie zag lopen, schoot ze hem aan met de vraag of hij niet iets kon regelen…

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Reposted by Albada Lab

Cees Dekker @ceesdekker.bsky.social · 13/03/2025

We have 3 openings for ambitious postdocs or PhD students in our #CDlab - for exciting single-molecule biophysics research on nuclear pores, peroxisomes, or archaeal divisomes. Check it out and apply: ceesdekkerlab.nl/come-join-us/ RT=nice!

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Albada Lab @albadalab.bsky.social · 13/03/2025

Great to be at the annual Biotech Booster event. Happy to be among the 50 PoPs, looking forward to connect with potential users of our technology. #biotechbooster #sandwich4nanopore #WUR

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Albada Lab @albadalab.bsky.social · 25/01/2025

Time to leave Bolzano, and I do that with a sense of great admiration for the field of single molecule protein sequencing #SMPS2025. A superfast moving field, and I’m asked looking forward to the next edition in Thailand. Hopefully I can present our contributions then as well!

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Albada Lab @albadalab.bsky.social · 23/01/2025

Thanks Cees! Was a pleasure to present our innovative technology to the SMPS community! Hope it helps to advance the field forward and allow it to connect to biological peptides and proteins.

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Reposted by Albada Lab

SMPS4 @smps4.bsky.social · 23/01/2025

Bauke Albada from Wageningen University & Research presented on 'An Orthogonal Click Approach to Convert Biological Proteins into Peptide-DNA Conjugates for Nanopore Reading. #SMPS4

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Cees Dekker @ceesdekker.bsky.social · 20/01/2025

The single molecule protein sequencing conference SMPS2025 has been opened by organizers @chancao.bsky.social and Denis Garoli! www.smps2025.com #SMPS4

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Albada Lab @albadalab.bsky.social · 06/01/2025

Come join our vibrant interdisciplinary team in the middle of the Netherlands in Wageningen! We're looking for a strong female candidate. www.wur.nl/nl/en/vacatu...

wur.nl

Assistant/Associate Professor in Bio-Organic Chemistry

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Albada Lab @albadalab.bsky.social · 31/12/2024

We only met once, in Wageningen, but your interaction with us made a lasting impression. Many of my students still wear their labcoat with your signature with pride. It was a great honor to have dined with you, and to share our scientific work. Rest in peace, Fraser!

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Albada Lab @albadalab.bsky.social · 28/12/2024

Fantastic! Raising the saddle an inch, or two, makes the ride more comfortable (although hopping on the bike takes a bit more practice). Enjoy the rides!

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Albada Lab @albadalab.bsky.social · 03/12/2024

The final version of our Nature Chemistry paper on the first artificial catch bond system is out! We've finally been able to do what nature has implemented throughout living systems: bonds that strengthen under external applied tension. Great work from Wageningen @w-u-r.bsky.social. rdcu.be/d2hi8

rdcu.be

De novo DNA-based catch bonds

Nature Chemistry - Whereas bonds that strengthen under mechanical stress occur frequently in nature, all synthetic bonds weaken under force. Now, an artificial supramolecular catch bond has been...

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