How do ABC transporter domains communicate with each other?
In our new study we adressed this question using the type VI ABC transporter of the lipopolysaccharide transport system and 19F ultrafast MAS NMR.
Thanks to everyone involved in this project!
Here is the preprint:
biorxiv.org
Conformational selection drives substrate-ATP coupling in the type VI ABC transporter
The mechanism of substrate-ATP coupling is central to the function of ABC transporters. Substrates bind to the specialized transmembrane domains (TMDs), whereas ATP binding and hydrolysis occur in the...
