TenBarge et al. show that lupus-associated TLR7/9 and type I interferon signaling reprogram neutrophil NET responses during Staphylococcus aureus infection. This shifts neutrophils away from LDHB-depe...

Microbial communities are present on nearly every surface of the human body. These microbiomes exist as dynamic ecosystems that are influenced by heterogeneous nutritional and chemical landscapes, the...

Acosta et al. find that ADP-ribosylation of the lipoic acid carrier protein GcvH-L promotes Staphylococcus aureus resistance to oxidative burst and facilitates infection. ADP-ribosylation leads to a s...

Cell metabolism plays a key role in shaping immune cell differentiation and function, with each immune cell subset depending on distinct metabolic pathways. While there have been extensive studies and...

Historically, neutrophil mitochondria were overlooked as they do not contribute to energy homeostasis. Wise et al. reveal that neutrophil mitochondria can sense bacterial persistence in the phagosome ...

Diabetic infections are a reservoir for the emergence and proliferation of antibiotic resistance in Staphylococcus aureus.