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American Journal of Kidney Diseases @ajkd.bsky.social · 7h

Platelet Reactivity Expression Score and Major Adverse Cardiovascular and Limb Events in CKD bit.ly/4xu47Ii

Association between CKD and PRESS. (A) Distribution of PRESS z score by CKD status. (B) Distribution of PRESS z score by CKD severity. (C) Correlation between PRESS z score and eGFR. (D) Kaplan-Meier curves for freedom from MACLE stratified by PRESS and CKD status. (E) Risk of MACLE by PRESS and CKD status. Abbreviations: ANOVA, analysis of variance; CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; MACLE, major adverse cardiovascular and limb events; PRESS, Platelet Reactivity Expression Score.

American Journal of Kidney Diseases @ajkd.bsky.social · 13h

EDITORIAL: Bloodless Potassium: Can Artificial Intelligence–Enabled Electrocardiography Guide Both Acute Detection and Correction of Hypokalemia? bit.ly/4yCxmt1

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American Journal of Kidney Diseases @ajkd.bsky.social · 19h

Distribution of GFR in Apparently Healthy Indians bit.ly/4qy4T4n

Measured glomerular filtration rate (mGFR) of apparently healthy Indian subjects is shown for various ages compared to the mGFR of apparently healthy individuals from the European population. Red lines: Median and 2.5th and 97.5th regression quantiles based on second-degree polynomials for Indian apparently healthy subjects.

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American Journal of Kidney Diseases @ajkd.bsky.social · 06/10/2026

An Interactive Virtual Nephrologist to Engage Patients With Advanced CKD About Transplantation bit.ly/4z0Bjbg (OPEN ACCESS)

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American Journal of Kidney Diseases @ajkd.bsky.social · 06/10/2026

Blood Leak Alarms With Hydroxocobalamin Administration bit.ly/4dq6cgp

Suggested algorithms for handling blood leak alarms derived from our institution’s protocol: (A) if blood is visualized; (B) if blood is NOT visualized.

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American Journal of Kidney Diseases @ajkd.bsky.social · 06/10/2026

The October 2026 issue of AJKD is available now! Check out the plain-language summaries on what inspired each study, the basic approach taken, what was learned, and why it matters: bit.ly/46V3wDR

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American Journal of Kidney Diseases @ajkd.bsky.social · 05/10/2026

Hospitalizations With Pericarditis and Pericardial Effusions in People With Kidney Failure Receiving Dialysis in the United States (2016-2021) bit.ly/4qiSS2s @winkeldoc

Annual totals and rates of hospitalizations for pericarditis/pericardial effusions for the US prevalent dialysis population, 2016-21 in which cardiac tamponade or cardiogenic shock were present. Notes: Numbers are estimates using the National Inpatient Sample (Panel A), and from both the National Inpatient Sample and the 2023 Annual Data Report of the United States Renal Data Service (Panel B).8 Dotted lines represent 95% confidence intervals.

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American Journal of Kidney Diseases @ajkd.bsky.social · 05/10/2026

The ‘Known Unknowns’ of CKD of Undetermined Etiology In 2026 bit.ly/4ebVfPG (OPEN ACCESS)

Burden of low eGFR in working-age rural males without hypertension, diabetes or heavy proteinuria. Age-standardised estimates in the 18–60-year-old population from the DEGREE collaboration. Released under a CC BY 4.0 license from Rutter et al.

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American Journal of Kidney Diseases @ajkd.bsky.social · 05/10/2026

Risks of Postpartum Kidney Disease Following Preeclampsia and Gestational Hypertension bit.ly/4wf6TQ3 (OPEN ACCESS)

Association of preeclampsia with and without severe features compared to gestational hypertension 0-29, 30-59, 60-89, 90-179, 180-365 days after delivery for any acute kidney injury and chronic kidney disease (confounder-adjusted hazard ratio with 95% CI), Nationwide Readmissions Database, 2010 to 2020

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American Journal of Kidney Diseases @ajkd.bsky.social · 04/10/2026

The October 2026 issue of AJKD is available now! Check out the plain-language summaries on what inspired each study, the basic approach taken, what was learned, and why it matters: bit.ly/46V3wDR

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American Journal of Kidney Diseases @ajkd.bsky.social · 04/10/2026

An Unexpected Cause of Early Allograft Dysfunction: A Quiz bit.ly/3VsIn1f (FREE)

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American Journal of Kidney Diseases @ajkd.bsky.social · 02/10/2026

NEW Blog Interview from Timothy Yau and Ikechi G. Okpechi on the #AJKDBlog: Chronic Kidney Disease Prevalence in Africa bit.ly/4xQzuvP (FREE)

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American Journal of Kidney Diseases @ajkd.bsky.social · 02/10/2026

A Perspective on the Role of Nephrologists in the Cardio-Kidney-Metabolic Syndrome bit.ly/47vv4jd (OPEN ACCESS)

The roles for nephrologists within the CKM Framework across the spectrum of kidney diseases. The outer rim represents distinct subs-specialties within which nephrologists may integrate the CKM framework and vice-versa. Abbreviations: AKI= acute kidney injury; AKD = acute kidney disease; CKD = Chronic Kidney Disease; CKM = Cardiac Kidney Metabolic

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American Journal of Kidney Diseases @ajkd.bsky.social · 02/10/2026

Perceptions of Hispanic Patients with Advanced CKD About Communication and Engagement Regarding Kidney Transplantation: A Qualitative Study bit.ly/4g7lPLn

Interview themes overlaid on Berlo’s framework. The Berlo’s communication framework views communication as the transfer of information and includes four components: the source or sender, the message or encoding of the message, channel or the delivery method of the message, and the receiver of the message. This figure overlays linguistic context, conversational context, socioemotional context and informational context on the Berlo’s framework to depict the main themes identified in the interviews.

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American Journal of Kidney Diseases @ajkd.bsky.social · 01/10/2026

Associations of Pre-Pandemic CKD With Acute and Post-Acute COVID-19: The C4R Study bit.ly/4whjJON (OPEN ACCESS)

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American Journal of Kidney Diseases @ajkd.bsky.social · 01/10/2026

Application of a Kidney Hierarchical Composite Endpoints in Trials of CKD Progression: Report of a Scientific Workshop Sponsored by the National Kidney Foundation bit.ly/4z8VeUR

Illustration of the analysis of a hierarchical composite endpoint. In a hypothetical trial, 6 participants are assigned to active treatment (A) or control group (C) and followed for a hierarchical composite endpoint of death (most clinically important) or kidney failure (Panel A). Each participant assigned to active treatment is compared to each assigned to the control group in a pairwise manner (Panel B). For each pairwise comparison, the most clinically important outcome that occurs during shared follow-up time is used to determine whether the participant assigned to active therapy has a better outcome (“win”), worse outcome (“loss”) or “tie” (Panel C). For example, participant A1 was alive when participant C1 died (a “win”) but died while participants C2 and C3 were alive (“losses”). Participant A2 was alive when participant C1 died (a “win”), reached kidney failure after participant C2 (with neither participant dying, a “win”), and reached kidney failure at the same time as partici

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American Journal of Kidney Diseases @ajkd.bsky.social · 01/10/2026

Time in Target Range for Hemoglobin A1c and Systolic Blood Pressure: Association With Adverse Kidney Events bit.ly/4wIbHOR

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American Journal of Kidney Diseases @ajkd.bsky.social · 30/09/2026

Advice for Living With Hemodialysis: A Qualitative Study of Older Patients and Their Care Partners bit.ly/4dWnlPx #OpenAccess

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American Journal of Kidney Diseases @ajkd.bsky.social · 30/09/2026

The Role of Angiopoietin-Like Proteins 3 and 4 and Their Target Lipases in CKD: A Drug-Target Mendelian Randomization Study bit.ly/4z0oNb6 (OPEN ACCESS)

Study design and biological mechanisms. ANGPTL3 inhibits lipoprotein lipase and endothelial lipase. ANGPTL4 inhibits lipoprotein lipase and hepatic lipase. Lipoprotein lipase hydrolyzes TG in lipoproteins. Endothelial lipase and hepatic lipase remodel HDL particles from larger, more buoyant HDL2 particles to smaller, denser HDL3 particles, which results in a decrease in HDL-C. Images are provided by NIAID NIH BIOART Source (bioart.niaid.nih.gov/bioart/171) and Servier Medical Art (https://smart.servier.com/), licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). ANGPTL, angiopoietin-like protein; CKD, chronic kidney disease; eGFRcrea, estimated glomerular filtration rate based on serum creatinine; EL, endothelial lipase; HDL, high-density lipoprotein; HL, hepatic lipase; LDL, low-density lipoprotein; LPL, lipoprotein lipase; TG, triglycerides; VLDL, very low-density lipoprotein.

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American Journal of Kidney Diseases @ajkd.bsky.social · 30/09/2026

EDITORIAL: Time in Target Range: The Optimal Marker for Kidney Protection bit.ly/3VnDSVG (FREE)

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American Journal of Kidney Diseases @ajkd.bsky.social · 29/09/2026

EDITORIAL: Saying the Quiet Part Out Loud: Resurfacing the Under-Recognized Needs of Patients and Care Partners bit.ly/4jzqNCy (FREE)

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American Journal of Kidney Diseases @ajkd.bsky.social · 29/09/2026

Normoproteic Plant-Dominant Protein Diets, Uremic Toxins, and Gut Microbiota in Patients With Advanced CKD: A Randomized Controlled Trial bit.ly/4hlfL2s

Results of the co-primary outcomes Changes in serum uremic toxin levels from baseline to Week 4 are shown. Serum TMAO levels were significantly reduced in the 70% plant-protein diet group compared with the control group, whereas no significant differences were observed for indoxyl sulfate or p-cresyl sulfate. FDR-adjusted P-values were calculated based on the Benjamini-Hochberg procedure. Bars indicate 95% confidence intervals. Abbreviations: FDR, false discovery rate; TMAO, trimethylamine N-oxide.

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American Journal of Kidney Diseases @ajkd.bsky.social · 29/09/2026

A Call for More Sensitive Patient-Centered Communication and Support After Canceled Transplant Surgeries bit.ly/4xoGKPP (FREE)

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American Journal of Kidney Diseases @ajkd.bsky.social · 28/09/2026

NEW Blog Commentary from AJKD Editorial Intern Dr. Elias John Elenjickal on the #AJKDBlog: Rethinking Osteoporosis Therapy in Chronic Kidney Disease bit.ly/4dPHXbp (FREE)

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American Journal of Kidney Diseases @ajkd.bsky.social · 28/09/2026

Carbamylation as a Novel Marker of Coronary Artery Calcification in People With CKD: Findings from a Phenome-Wide Association Study in CRIC bit.ly/4xMU6VK

PheWAS results for continuous phenotypes. Each linear regression model uses the log-transformed and standardized carbamylated albumin (C-Alb) as the exposure and a log-transformed phenotype as the outcome, adjusted for age, sex, race and ethnicity, eGFR, and urinary protein. Effect sizes are shown as exponentiated beta coefficients, representing the proportional change (i.e., multiplicative effect or fold change) in the phenotype per 1 standard deviation increase in log-C-Alb. Panel A). Filled circles indicate statistical significance at the Benjamini–Yekutieli-corrected False Discovery Rate (FDR) threshold. Panel B) Displays only the significant continuous phenotypes. Abbreviations: SUN, serum urea nitrogen; LAD, left anterior descending; HDL, high density lipoprotein; MAP, Mean Arterial Pressure; CO2, Carbon dioxide; HA1C, Hemoglobin A1C, PLT, platelets; RBC, red blood cells; WBC, white blood cells; VLDL, very low-density lipoprotein.

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American Journal of Kidney Diseases @ajkd.bsky.social · 28/09/2026

The October 2026 issue is available now: bit.ly/4hhrLlI Highlights: - Advice for Living With Hemodialysis - Time in Target Range for Hemoglobin A1c and Systolic Blood Pressure - Associations of Pre-Pandemic CKD With Acute and Post-Acute COVID-19: The C4R Study

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American Journal of Kidney Diseases @ajkd.bsky.social · 25/09/2026

Safety of Sodium/Glucose Cotransporter 2 Inhibitors in Patients With Type 2 Diabetes and CKD bit.ly/4xIncFW (OPEN ACCESS)

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American Journal of Kidney Diseases @ajkd.bsky.social · 25/09/2026

Closing the Gap? Recent Trends in Racial Differences in Blood Pressure Control in the United States bit.ly/4ejC0TJ

Proportion of non-Hispanic Black and White US adults with hypertension who have uncontrolled blood pressure, NHANES 1999-2020 to 2021-2023. BP control is defined as systolic blood pressure <140 mmHg and diastolic blood pressure <90 mmHg according to the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Abbreviations: ACC, American College of Cardiology; AHA, American Heart Association; BP, blood pressure; COVID-19, Coronavirus-19; JNC7, Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure

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American Journal of Kidney Diseases @ajkd.bsky.social · 24/09/2026

Racial and Ethnic Disparities in Living Donor Kidney Transplantation in California: 2010-2024 bit.ly/3QL7Uk6 (OPEN ACCESS)

Racial/Ethnic Disparities in 2-Year Living Donor Kidney Transplantation among Waitlisted Candidates Preemptively and on Dialysis in California from 2010 to 2024. (A) and (C): California unadjusted 2-Year Probability of LDKT Following Kidney Transplant Waitlisting Preemptively or on Dialysis, respectively. (B) and (D): California Adjusted Subdistribution hazard ratios of 2-Year LDKT Following Kidney Transplant Waitlisting Preemptively or on Dialysis, respectively. An estimated adjusted subdistribution hazard ratio of less than 1 indicates that the racial/ethnic group is less likely to receive living donor kidney transplantation compared to White candidates. Competing risk analyses were performed using the Fine and Gray method.

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American Journal of Kidney Diseases @ajkd.bsky.social · 24/09/2026

NEW Blog Commentary from AJKD Editorial Intern Dr. Elias John Elenjickal on the #AJKDBlog: Rethinking Osteoporosis Therapy in Chronic Kidney Disease bit.ly/4dPHXbp (FREE)

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American Journal of Kidney Diseases @ajkd.bsky.social · 24/09/2026

Mental Health, Neurodegenerative, and Cardiovascular Health of Korean Kidney Transplant Recipients in Single-Person Households bit.ly/4jlVuet

Kaplan–Meier estimates of mental health and neurodegenerative diseases according to household type. Event-free survival curves were compared using the log-rank test.

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American Journal of Kidney Diseases @ajkd.bsky.social · 24/09/2026

Clinical and Social Risk Factors for 30-Day Readmissions in Children With Kidney Disease bit.ly/4gBQReQ

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American Journal of Kidney Diseases @ajkd.bsky.social · 23/09/2026

Self-Reported Versus Performance-Based Measures of Physical Function and Mortality Among Patients With Kidney Failure: A Cohort Analysis of the CONVINCE Trial bit.ly/4hKW7Mv (OPEN ACCESS) @gstrip3

Kaplan-Meier survival curves stratified by PROMIS physical function score cut-off categories across physical function measures, with corresponding cut point values and log-rank tests.

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American Journal of Kidney Diseases @ajkd.bsky.social · 23/09/2026

Temporal Trends in the Complexity of Nephrology Inpatients: A Population-Based Cohort Study bit.ly/3SmiZc5 (OPEN ACCESS)

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American Journal of Kidney Diseases @ajkd.bsky.social · 22/09/2026

Transplantation and Mortality as Competing Outcomes Among Patients on Dialysis With Newly Diagnosed Cancer: A Longitudinal Cohort Study bit.ly/4ppBDfH #OpenAccess

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American Journal of Kidney Diseases @ajkd.bsky.social · 22/09/2026

Complement in Kidney Disease: Core Curriculum 2026 bit.ly/4cTLy85

Overview of complement effects. Complement activation generates multiple effector molecules. C3 fragments (C3b, iC3b, C3d) are covalently bound to target cell membranes. C3b on the surface of target cells can form C3 convertase, leading to further complement activation at that site. Both iC3b and C3d are ligands for 4 complement receptors (CR1-4) expressed by leukocytes and dendritic cells. C3a and C5a are soluble peptides that are released during the cleavage of C3 and C5, respectively. They are ligands for receptors expressed by leukocytes and parenchymal cells. They induce multiple downstream functions, including the chemotaxis and activation of myeloid cells to sites of inflammation. Activation can also generate C5b-9 multimers on cell membranes. C5b-9 forms a pore through the outer membrane. In sublytic quantities this can cause cell activation. If sufficient C5b-9 is formed it can cause osmotic lysis of the cell. Created with BioRender.

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American Journal of Kidney Diseases @ajkd.bsky.social · 22/09/2026

Seasonality, Hospitalization, and Initiation of Home Dialysis: A Retrospective Cohort Study bit.ly/4vXICOM

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American Journal of Kidney Diseases @ajkd.bsky.social · 21/09/2026

Prevalence Estimates of Predicted Pathogenic COL4A3-COL4A5 Variants in the Chinese Population and Its Implications for Clinical Practice bit.ly/43r4RQY

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American Journal of Kidney Diseases @ajkd.bsky.social · 21/09/2026

Racial and Ethnic Variations in Reductions in Etelcalcetide Use After Withdrawal of the Transitional Drug Add-on Payment Adjustment bit.ly/46vR4Ky (OPEN ACCESS)

A: Unadjusted etelcalcetide, and cinacalcet prescriptions per quarter. Total bar represents sum of etelcalcetide and cinacalcet prescriptions (total calcimimetic use). Proportion of patients receiving at least one prescription per quarter. B: Percentage-point difference in etelcalcetide prescriptions per quarter, relative to Q4 2017, after adjustment for covariates, stratified by patient race/ethnicity. Estimates obtained by interacting indicators for each quarter with patient race/ethnicity. C: Percentage-point difference in any calcimimetic prescription per quarter, relative to Q4 2017, after adjustment for covariates, stratified by patient race/ethnicity. Estimates obtained by interacting indicators for each quarter with patient race/ethnicity. Dashed vertical lines represents January 1, 2018 and December 31, 2020, the beginning and end of TDAPA reimbursement payments, respectively. Asian/Other includes Asian, American Indian, Alaska Native, Native Hawaiian, Pacific Islander, Other

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American Journal of Kidney Diseases @ajkd.bsky.social · 20/09/2026

⚡️AJKD Express is an expedited consideration process for full-length original research articles: Authors of eligible #AJKDExpress articles will be notified of decision within 7-16 business days.⚡️ Details on #AJKDBlog: bit.ly/2Ws8rtp

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American Journal of Kidney Diseases @ajkd.bsky.social · 18/09/2026

Allocation of Kidney Allografts From Donors With Kidney Donor Profile Index <35% and the Impact of Kidney Donor Profile Index Revisions on Access to Transplantation for Children bit.ly/42iKSDu (OPEN ACCESS) @super_jrub

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American Journal of Kidney Diseases @ajkd.bsky.social · 18/09/2026

Allocation of Kidney Allografts From Donors With Kidney Donor Profile Index <35% and the Impact of KDPI Revisions on Access to Transplantation for Children bit.ly/42iKSDu #OpenAccess

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American Journal of Kidney Diseases @ajkd.bsky.social · 18/09/2026

Beyond Genotype: Proteomic Risk Stratification for APOL1-Mediated Kidney Disease bit.ly/471bxqK

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American Journal of Kidney Diseases @ajkd.bsky.social · 18/09/2026

#KDOQI US Commentary on theKDIGO 2026 Clinical Practice Guideline for the Management of Anemia in CKD bit.ly/KDOQI26Anemia (FREE)

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American Journal of Kidney Diseases @ajkd.bsky.social · 15/09/2026

Joint Impact of Aldosterone and Low-Density Lipoprotein Cholesterol on Cardiovascular Risk in CKD bit.ly/4A2iUvt

Restricted cubic spline plota,b,c,d of the association of serum aldosterone with major cardiovascular events (MACE) across levels of low-density lipoprotein (LDL) in persons with CKD and without baseline cardiovascular disease aThe plot depicts the hazard ratio for each doubling of serum aldosterone across varying levels of LDL. Hazard ratios are calculated using LDL = 70 mg/dL as the reference. The solid line represents the estimated hazard ratio, while the shaded area indicates the 95% confidence interval.

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American Journal of Kidney Diseases @ajkd.bsky.social · 14/09/2026

NEW Commentary by Natasha Freeman on the #AJKDBlog: A Call for Better Cancer Screening Guidelines for Patients with Glomerular Disease bit.ly/4A5ziLx

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