🧪 Another paper from the group- from Lilian Koppensteiner, showing the direct functional synthesis of immunosuppressive adenosine in lung cancer and the prognostic implications. www.tandfonline.com/doi/full/10....
Work from @edinuni-irr.bsky.social @cruk-si.bsky.social @ukri.org
tandfonline.com
Cancer associated fibroblast–T cell crosstalk promotes purinergic synthesis in non-small cell lung cancer (NSCLC)
The most abundant stromal cells of the tumor microenvironment (TME), cancer-associated fibroblasts (CAFs), inhibit the cytotoxic T cell response in solid tumors. CD39 and CD73 together deplete extr...