iiinova — where your digital self keeps evolving

Andrea Goldstein-Piekarski @agoldpie.bsky.social · 07/07/2026

Thank you to everyone who has supported this journey — colleagues, collaborators, participants, and my family. Science truly takes a village. #SleepScience #MentalHealth #AcademicLife #ScienceCommunication #Brainpod #CBTI #PrecisionPsychiatry #PostdocPosition #WorkLifeBalance

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Andrea Goldstein-Piekarski @agoldpie.bsky.social · 07/07/2026

🔍 𝐖𝐞'𝐫𝐞 𝐠𝐫𝐨𝐰𝐢𝐧𝐠: With these exciting developments, I'm also beginning to look for passionate postdoctoral researcher to join the lab in the coming months. If you're interested in the intersection of sleep, affective neuroscience, and mental health, let's connect!

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Andrea Goldstein-Piekarski @agoldpie.bsky.social · 07/07/2026

📢 𝐀𝐧𝐝 𝐭𝐡𝐢𝐬 𝐢𝐬 𝐣𝐮𝐬𝐭 𝐭𝐡𝐞 𝐛𝐞𝐠𝐢𝐧𝐧𝐢𝐧𝐠! This is one of several exciting updates from the lab that I'll be sharing over the upcoming days, including several new publications. Stay tuned for more insights into our work on sleep, mood, and precision psychiatry.

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Andrea Goldstein-Piekarski @agoldpie.bsky.social · 07/07/2026

This project holds a special place in my heart. It was my first large independent study, launched my lab, and survived the challenges of the pandemic — all while I was raising my 2 young kids. Seeing it come to fruition and reach broader audiences is incredibly rewarding.

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Andrea Goldstein-Piekarski @agoldpie.bsky.social · 07/07/2026

We dive into the science behind how targeting insomnia can improve depression — and why objective sleep measures matter for predicting treatment response.

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Andrea Goldstein-Piekarski @agoldpie.bsky.social · 07/07/2026

I had the privilege of discussing our work on sleep, depression, and CBT-I mechanisms with first author Adam Krause on @npp_journal official podcast. 🔗 𝐋𝐢𝐬𝐭𝐞𝐧 𝐡𝐞𝐫𝐞: podcasts.apple.com/gb/podcast/e... 🔗 𝐑𝐞𝐚𝐝 𝐭𝐡𝐞 𝐩𝐚𝐩𝐞𝐫: rdcu.be/fsCFA

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Andrea Goldstein-Piekarski @agoldpie.bsky.social · 23/05/2026

We’re hiring! My lab is looking for a Research Coordinator. Please share and reach out if you’re interested in #sleep, #mentalhealth, and #neuroscience. See our latest paper in @npp-journal.bsky.social: www.nature.com/articles/s41... Results are discussed more fully here 🧵: bsky.app/profile/agol...

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Andrea Goldstein-Piekarski @agoldpie.bsky.social · 22/05/2026

Thanks to collaborators and team Rachel Manber, Jared Saletin, James Gross, Jun Ma, Leanne Williams, Jerome Yesavage, Laura Lazzeroni, Rebecca Bernert, Maryam Ahmadi, study clinicians Raquel Osorno, Natalie Solomon, Kristen Burda, CoPsyN Sleep Lab, participants and @stanfordpsy.bsky.social 10/n

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Andrea Goldstein-Piekarski @agoldpie.bsky.social · 22/05/2026

This project launched my independent lab during the height of the pandemic — making this publication especially meaningful. And we're not done! We're currently in the second phase of the project! 🚀 9/n

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Andrea Goldstein-Piekarski @agoldpie.bsky.social · 22/05/2026

Addressing these questions are crucial because sleep interventions like CBT-I offer major advantages over traditional antidepressants: ✅ Lack stigma associated with depression treatment ✅ Fewer adverse events ✅ Accessible entry point for those hesitant to seek mood treatment 8/n

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Andrea Goldstein-Piekarski @agoldpie.bsky.social · 22/05/2026

• Objective sleep physiology (not just subjective report) may help identify who is most likely to benefit from CBT-I for depression This could move us toward more personalized treatment selection! 7/n

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Andrea Goldstein-Piekarski @agoldpie.bsky.social · 22/05/2026

🧠 Why this matters: •One of the first mechanistic examinations of how insomnia treatment confers antidepressant effects •Neural target engagement and clinical improvement can occur in parallel but through dissociable pathways 6/n

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Andrea Goldstein-Piekarski @agoldpie.bsky.social · 22/05/2026

🔑 KEY FINDING #3: Objective Sleep as a Predictor Pre-treatment objective sleep efficiency (not brain or self-reported symptoms) predicted antidepressant responses to CBT-I. Individuals with the LOWEST sleep efficiency at baseline showed the GREATEST improvement in depression. 5/n

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Andrea Goldstein-Piekarski @agoldpie.bsky.social · 22/05/2026

🔑 KEY FINDING #2: Dissociation Between Neural and Clinical Change But Improvements in depression were associated with better insomnia symptoms and objectively measured sleep efficiency NOT with normalization of fronto-limbic function. 4/n

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Andrea Goldstein-Piekarski @agoldpie.bsky.social · 22/05/2026

🔑 KEY FINDING #1: Mechanistic Target Engagement CBT-I reduced amygdala reactivity to fearful faces—showing engagement of fronto-limbic emotional circuitry—while also producing improvements in depressive symptoms and both objective & self-reported sleep disturbance. 3/n

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Andrea Goldstein-Piekarski @agoldpie.bsky.social · 22/05/2026

The big questions: When CBT-I improves depression in people with comorbid insomnia and depressive symptoms — HOW does it work and WHOM is it likely to benefit? Through changes in emotion-processing brain circuits? Or through improvements in sleep itself? 2/n

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Andrea Goldstein-Piekarski @agoldpie.bsky.social · 22/05/2026

🧵 Targeting sleep to treat depression: New mechanistic insights from the TIRED Study Thrilled to share our first major paper in @npp-journal.bsky.social! Led by Adam Krause, we examined how CBT-I improves depression in people with comorbid insomnia. Paper: www.nature.com/articles/s41... 1/n

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Reposted by Andrea Goldstein-Piekarski

Umair Hassan @neuro-engineer.bsky.social · 12/05/2026

This achievement would not have been possible without the immense support and thoughtful critique of my mentor @coreykeller who trusted my vision, my PhD supervisor @tobergmann who first introduced me to brain stimulation, and to my wonderful co-mentors Josef Parvizi and @agoldpie.bsky.social

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Andrea Goldstein-Piekarski @agoldpie.bsky.social · 26/01/2025

In a time with so much uncertainty it's nice to have hobbies that bring joy and relieve stress. Mine also comes with lots of sugar. Still a lot of learning to do, but having fund doing it! #cookieart #stressrelief #yum #snowflake

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Reposted by Andrea Goldstein-Piekarski

Tired Ass Profs @tired-profs.bsky.social · 23/01/2025

Oh great… the same new PIs who were hit by a global pandemic just as they started are now trying to renew their grants and get tenure when the funding agencies are actively being destroyed. But sure.... that COVID tenure clock extension reeaaallly made a difference....

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