Ageing is linked to environmental factors. This study shows that although participants gradually adapted to heat over time, cumulative exposure to heatwaves had stable and adverse impacts on ageing, e...

Glycation, a deleterious form of post-translational modification of macromolecules has been linked to diseases such as diabetes, cataract, Alzheimer’s, dialysis related amyloidosis (DRA), atherosclero...

Dissecting the effects of hypothermic and hypometabolic states on aging processes, the authors show that activation of neurons in the preoptic area induces a torpor-like state in mice that slows epige...

Fuentealba and colleagues build and validate a DNA methylation clock of intrinsic capacity (IC) to bridge resource-intensive clinical assessments of IC with molecular readouts of aging, highlighting s...

Adolescents are the future leaders of our world. Ensuring their health and wellbeing—now and in the future—is one of the strongest mechanisms available to safeguard the collective future of humanity a...

Heat waves, defined as periods with daily temperatures surpassing the historical average for a specific region, have become more frequent worldwide in recent years. Previous studies have reported a ne...

All of statistics and much of science depends on probability — an astonishing achievement, considering no one’s really sure what it is.

Caloric restriction (CR) causes a reduction in body temperature (Tb) which is suggested to contribute to changes that increase lifespan. Moreover, low…