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Andy Posbe

@adnroide.bsky.social

161 followers 147 following 21 posts

PhD student at @TheSainsburyLab.bsky.social working on NLR bioengineering and computational prediction of immune receptor activities w/ @KamounLab.bsky.social . 🇦🇷🏳️‍🌈 (he/him)

Posts Replies Media

Andy Posbe @adnroide.bsky.social · 11/09/2026

No one remembers authorising this firmware update

Five researchers hold freshly printed immune receptor structures while the office Ricoh continues production, despite nobody remembering authorising this feature.

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Andy Posbe @adnroide.bsky.social · 10/09/2026

Lesson 9 - Structural Modeling Can Guide Protein Engineering From prediction to design! 🛠️ Interfaces can guide changes that transfer recognition, restore function or create new connections. Combined with binder design, they can help build new immune receptor specificities.

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Andy Posbe @adnroide.bsky.social · 10/09/2026

Lesson 6 - AI Can Reveal Novel Protein–Protein Interactions From screening entire proteomes to identifying short binding motifs, modelling can uncover new partners and explain how they interact, generating testable hypotheses and guiding experimental discovery.

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Andy Posbe @adnroide.bsky.social · 10/09/2026

Lesson 4 — Structural Similarity Can Reveal Hidden Relationships Proteins with no detectable sequence similarity can share a fold. Comparing predicted structures across families or proteomes can uncover connections that sequence searches miss. 🔍

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Andy Posbe @adnroide.bsky.social · 10/09/2026

Lesson 3 — Model Your Proteins with Other Molecules Proteins have company! Lipids, nucleic acids, ions and ligands shape their biology. Including relevant partners can reveal interfaces and improve regions that are poorly modelled in isolation.

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Andy Posbe @adnroide.bsky.social · 10/09/2026

On tοοls and metrics 🧰 Aside from the lessons, we put together a table of what's currently available and what each tool and metric is actually for. Reproduced below. Links in the reply.

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Andy Posbe @adnroide.bsky.social · 10/09/2026

Lesson 1 — Don’t Ignore Confidence Metrics 🔍 A model can be uncertain overall yet reliable at the interface that matters. Read local and interface scores alongside global confidence to judge which parts support your biological hypothesis.

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Andy Posbe @adnroide.bsky.social · 10/09/2026

Excited to share Fold on Tight! 🎉 We distil recent advances in plant immunity into 10 lessons for using AI structure prediction critically and effectively, in plants and beyond. 📝 zenodo.org/records/2210...

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Andy Posbe @adnroide.bsky.social · 30/10/2025

Spooky season has arrived! 👻 We held our annual Pumpkin Carving Competition at @thesainsburylab.bsky.social —vote for your favourite carve! 🎃🕯️

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