iiinova — where your digital self keeps evolving

Acta Neuropsychiatrica @actaneuropsych.bsky.social · 03/08/2026

hildhood trauma was associated w/ higher inflammation, which was linked to both mental health symptoms and poorer metabolic health • Higher physical activity was associated with lower insulin resistance + fewer depressive symptoms 📖 Read the article for more: doi.org/10.1017/neu....

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 03/08/2026

What are the relationships between childhood trauma, inflammation, metabolic health, and mental health in a community sample of adults? @gemmawallace.bsky.social @lkaychicago.bsky.social brickphd.bsky.social et al., showed that: #ChildhoodTrauma #MentalHealth #Inflammation #MetabolicHealth

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 03/08/2026

Associations between task performance and symptoms of depression or anxiety were inconsistent It highlights important gaps in the field and emphasizes the need for + longitudinal and intervention studies. 📖 Read the review: dub.sh/27zWac4 #Depression #Anxiety #Neuropsychology #SelfRegulation

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 03/08/2026

🧠 Can neuropsychological tasks improve our understanding of depression and anxiety in adolescents? A recent scoping review examined the use of three widely used paradigms: • Emotional Go/No-Go (EGNG) • Delay Discounting Task (DDT) • Balloon Analogue Risk Task (BART)

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 08/06/2026

A 25-year longitudinal birth cohort study from Estonia reveals how genes, biomarkers, environment, and family shape behavior, mental health, and life trajectories. Findings offer key insights into neurodevelopment, psychiatric risk! @neuropsychochem.bsky.social doi.org/10.1017/neu....

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Insights into neuroscience from the representative birth cohort samples of a multidisciplinary longitudinal study | Acta Neuropsychiatrica | Cambridge Core

Insights into neuroscience from the representative birth cohort samples of a multidisciplinary longitudinal study - Volume 38

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 26/04/2026

We remember with admiration Dr. Stein behind this contribution, whose work, curiosity, and generosity helped advance not only science, but the neuropsychopharmacology community. A lasting contribution and a meaningful legacy.

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 26/04/2026

It also explores the mechanistic basis of these effects, including receptor interactions that may promote axonal remyelination and reduced excitotoxicity. The review points to a compelling possibility: ibogaine’s therapeutic value may extend beyond symptom relief to supporting neural repair.

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Neurorestorative properties of ibogaine: linking multi-receptor affinities to remyelination and metabolic restoration | Acta Neuropsychiatrica | Cambridge Core

Neurorestorative properties of ibogaine: linking multi-receptor affinities to remyelination and metabolic restoration - Volume 38

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 26/04/2026

In this review, authors examine the potential of ibogaine to support white matter repair following CNS injury. Drawing on preclinical evidence, observational data, and case reports, the paper highlights early signals that #ibogaine may improve outcomes in MS,TBI and opioid use disorder.

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 26/04/2026

Some papers carry more than scientific weight: they carry legacy. This study honors a deeply respected contributor to Acta Neuropsychiatrica and a leading figure in psychiatry, whose impact continues to shape the field. doi.org/10.1017/neu....

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 28/03/2026

These non-pharmacological, technology-delivered approaches offer accessible support and align with young adults' lifestyle. A promising step toward scalable mental health support. Check the study for more info: doi.org/10.1017/neu....

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 28/03/2026

Improvements on – Anxiety and mood regulation – Sleep quality – Stress-related physiological markers – Cognitive performance Effect sizes indicate clinically meaningful, though not large effects.

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 28/03/2026

How effective are music-based interventions for mental health in young adults? In this systematic review of clin trials in young adults, found that music therapy, binaural beats & rhythm-based auditory stimulation are associated w/ moderate improvements across multiple domains:

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 06/02/2026

🧩 Findings suggest Autoantibodies may represent an under-recognized source of psychiatric vulnerability in 22q11DS, acting alongside the genetic deletion 🔬 This perspective opens new directions for research and clinical consideration, including immunological screening doi.org/10.1017/neu....

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 06/02/2026

📄 Individuals with 22q11DS may develop • increased circulating autoantibodies & elevated inflammatory markers, • increased blood–brain barrier (BBB) permeability • Converging evidence shows that antibodies targeting neural proteins can induce psychiatric symptoms

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 06/02/2026

🧠🧬 Autoimmunity as an underexplored contributor to neuropsychiatric symptoms in 22q11.2 deletion syndrome A recent study synthesizes evidence linking autoimmune processes to the neuropsychiatric phenotype observed in 22q11.2 deletion syndrome (22q11DS).

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 23/01/2026

More importantly, these findings underscore that behavioral patterns and mental well-being are deeply connected. This study highlights the need for integrated support frameworks and policies that address the root causes of mental health in adolescents. doi.org/10.1017/neu....

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Behavioural Addiction and Associated Risk Factors Among High School Students | Acta Neuropsychiatrica | Cambridge Core

Behavioural Addiction and Associated Risk Factors Among High School Students

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 23/01/2026

It identifies strong links to underlying mental health: •Food addiction was tied to depression, anxiety &stress •Problematic internet use was linked to depression &stress •Internet gaming disorder was associated with anxiety

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Behavioural Addiction and Associated Risk Factors Among High School Students | Acta Neuropsychiatrica | Cambridge Core

Behavioural Addiction and Associated Risk Factors Among High School Students

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 23/01/2026

The research reveals notable prevalence rates: •Food addiction 6.9% •Problematic internet use 14.3% •Internet gaming disorder 0.9% The high rate of problematic internet use reflects the digitally immersive world

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 23/01/2026

How prevalent are behavioural addictions among adolescents? A newly published study in Acta Neuropsychiatrica suggests insights by examining multiple behavioral addictions simultaneously.

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 10/01/2026

📌 Clinically, this supports a nuanced view of BPD: social difficulties may be amplified by interpersonal stress and emotional load, not by a global inability to process fairness or social norms. READ here for more: doi.org/10.1017/neu.... #Psychiatry #ClinicalPsychology

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Neuroeconomic adaptation to norm shifts is preserved in borderline personality disorder | Acta Neuropsychiatrica | Cambridge Core

Neuroeconomic adaptation to norm shifts is preserved in borderline personality disorder

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 10/01/2026

These findings suggest that social impairments in BPD may be context-dependent, rather than pervasive Differences in behavior and neural processing may emerge primarily under stressful, disorder-relevant interpersonal contexts, rather than in neutral, one-shot interactions w/strangers #Borderline

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 10/01/2026

🔹 BPD showed higher overall rejection rates of monetary offers 🔹 recognized and responded to fairness norm violations similarly to controls 🔹 Neural data revealed different roles in the PFC: • vmPFC encoded linear value (valence) • dmPFC/dlPFC encoded quadratic salience (norm prediction errors)

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 10/01/2026

Decision-making in Borderline Personality Disorder (BPD) in Social Context A recent fMRI study publishe in Acta Neuropsychiatrica used a multi-round Ultimatum Game to examine fairness, norm violations, and value processing in individuals with BPD. #fMRI #SocialCognition

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 22/12/2025

As we approach the end of 2025, we would like to send a warm thank you to the entire Acta Neuropsychiatrica community —our dedicated authors, diligent reviewers & committed editorial board members. On behalf of the Acta Neuropsychiatrica and the board of the SCNP.

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 19/12/2025

⚠️ Caveats: • As in psychiatry, no single, universal biomarker exists. The future likely lies in multi-marker panels. • Findings are primarily preclinical; human translation is the next critical step. Read more: doi.org/10.1017/neu.... #Neuroscience #Biomarkers #ASDResearch #Exosomes

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Exosomes: New Biomarker and Therapeutic Candidates in Autism Spectrum Disorder Research | Acta Neuropsychiatrica | Cambridge Core

Exosomes: New Biomarker and Therapeutic Candidates in Autism Spectrum Disorder Research

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 19/12/2025

🧬Mechanistics: Extracellular vesicles offer a dynamic snapshot of cellular communication 🩸Diagnostic: Accessibility makes low invasive diagnostical tool 💊Therapeutics: Administering exosomes derived from healthy sources has shown behavioral improvements in preclinical ASD models

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 19/12/2025

🧩Exosomes: A New Frontier in Understanding & Treating Autism Spectrum Disorder (ASD) How can they advance ASD research?

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 05/12/2025

🔹 Understanding how the DDCS function across different vertebrates, supporting navigation, decision-making & stress resilience, may offer insights into human mental health and how our own brains cope (or fail) with displacement, uncertainty and change. doi.org/10.1017/neu....

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 05/12/2025

✨ At the center of this discussion is the dorsal diencephalic conduction system (DDCS) • a highly conserved pathway (stria medullaris → habenula → fasciculus retroflexus) • central to flexible responses in social, defensive, and reward-related contexts • and a decisive hot spot in neuropsychiatry.

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 05/12/2025

🧠 Our brain circuits were shaped under these conditions, and some of the most ancient pathways remain deeply conserved across vertebrate species. This recent review highlights a fascinating framework: looking beyond mammals and exploring alternative models for studying human mental disorders.

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 05/12/2025

🧭 Modern humans often face intense stress when uprooted from a familiar and safe environment… yet our nomadic ancestors evolved under constant movement as hunter-gatherers.

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 05/12/2025

🌍 From nomadic origins to modern stress: what can birds teach us about mental health? doi.org/10.1017/neu....

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 21/11/2025

Could the neural plasticity associated with psychedelics extend beyond mood or perception towards functional recovery itself? ✨ Interesting protocol alert: a randomised dose-comparison design testing whether psilocybin + physiotherapy can restore motor function and body–brain coherence.

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 21/11/2025

🧠 Could psychedelics help rewire the brain–body disconnect? 💊 + 🧍‍♀️A new pilot study explores this question by investigating psilocybin-assisted therapy in Motor Functional Neurological Disorder (FND), pairing pharmacological and rehabilitative approaches.

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 07/11/2025

💡 The hybrid format (digital + classroom) and easy-to-read, gamified materials made the program accessible, engaging, and equally effective across rural and urban schools, as well as regular and special education centers. #HealthLiteracy #DigitalHealth #Neurodiversity #EquityInHealth

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 07/11/2025

🩺 Building Early Pain Literacy Pain-related knowledge can improve quality of life and satisfaction, and the sooner the better ✨In a new study, a pain neuroscience education (PNE) program significantly improved outcomes in adolescents with and without intellectual disabilities.

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 27/10/2025

🌿 Results: Psilocybin produced rapid antidepressant effects, often after one or two supported sessions. Improvements were sustained for several weeks or months. Treatment is generally well-tolerated with some mild headaches and transient anxiety - typically manageable in controlled settings.

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 27/10/2025

🍄 What does the evidence say on Psilocybin Therapy in Depression? 📄 A new PRISMA-guided systematic review analyzed 22 clinical studies, including randomized controlled + open-label trials. Populations included treatment-resistant depression and varied dosing and adjunctive protocols

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 24/10/2025

⚡Proinflammatory cytokines activate breakdown into tryptophan catabolites (TRYCATs). However, some TRYCATs (like kynurenine, 3HK) are neurotoxic! Patients with MNP exhibit 🔺 quinolinic acid and 🔻 kynurenic acid, shifting the quinolinic:kynurenic ratio toward neurotoxicity.

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 24/10/2025

🧩 Rethinking Schizophrenia Emerging evidence suggests schizophrenia has 2 biologically distinct forms: 🔹 Major Neurocognitive Psychosis (MNP) 🔹 Simple Neurocognitive Psychosis (SNP) Both differ in immune and metabolic pathways, especially in how the brain processes tryptophan (TRP)

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 17/10/2025

It is a potent mid-tier option, Shared decision-making, weighing symptom severity, side effects: ✅ D2-based intolerants ✅ Individuals w/ metabolic concerns ✅ Prominent cognitive & negative symptoms ✅ Partial responders ➡️ GI side effects can be a barrier ➡️ Don't switch stable patients

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Xanomeline-trospium: defining its place among the current antipsychotic landscape | Acta Neuropsychiatrica | Cambridge Core

Xanomeline-trospium: defining its place among the current antipsychotic landscape - Volume 37

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 17/10/2025

Navigating the Use of Xanomeline/Trospium (Cobenfy/KarXT) KarXT marks a significant shift as the first muscarinic Our latest paper breaks down the key patient profiles that may benefit most from this novel mechanism of action: doi.org/10.1017/neu....

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 10/10/2025

Voice revealed: 🎵 Specific changes in speech rhythm, pitch, and energy correlated with rises in both cortisol and state anger 🚻 These vocal patterns differed meaningfully between males and females 🤖 Computational models demonstrated that speech can predict stress-related scores w/ moderate accuracy

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Acta Neuropsychiatrica @actaneuropsych.bsky.social · 10/10/2025

🎤 Voice over for measuring the physiological stress response. What if the speech could be used as a digital biomarker of stress? Using a validated stress-induction paradigm, researchers analyzed vocal features in relation to salivary cortisol and state anger.

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